Multidimensional Phenotype Classification in Grade 3 Bronchopulmonary Dysplasia

RecruitingOBSERVATIONAL
Enrollment

130

Participants

Timeline

Start Date

December 5, 2023

Primary Completion Date

December 31, 2028

Study Completion Date

July 31, 2029

Conditions
Bronchopulmonary Dysplasia
Interventions
DIAGNOSTIC_TEST

Chest computed tomography (CT) with angiography

A CT scan uses a doughnut-shaped machine to take x-rays in a circle around the body. CT scans help doctors learn about the structure of the lungs, heart, and blood vessels in the chest. A CT scan provides more information than regular x-rays. CT w/angiography - injection of intravenous contrast during the CT to image the blood vessels within the chest.

DIAGNOSTIC_TEST

Bronchoscopy with bronchoalveolar lavage

During a bronchoscopy, a lung doctor inserts a small flexible camera into the breathing tube and main branches of the airways within the lungs. During the test, a small amount of sterile fluid is placed into the lung and then retrieved (lavage). This fluid is tested for evidence of infection.

DIAGNOSTIC_TEST

Echocardiography

An echo uses sound waves to create computer pictures of the heart.

DIAGNOSTIC_TEST

"24 hour esophageal pH (potential of hydrogen) - multichannel intraluminal impedance (MII) monitoring (reflux testing)"

24 hour pH/MII testing is used to measure gastroesophageal reflux. A small feeding tube like catheter is passed through the nose or mouth into the esophagus. The catheter is used to measure the frequency and acidity of reflux episodes during a 24 hour monitoring period.

Trial Locations (1)

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Children's Hospital of Philadelphia

OTHER