Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

PHASE3RecruitingINTERVENTIONAL
Enrollment

528

Participants

Timeline

Start Date

November 27, 2024

Primary Completion Date

June 30, 2027

Study Completion Date

April 30, 2032

Conditions
Castration-Resistant Prostate CarcinomaStage IVB Prostate Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Bone Scan

Undergo bone scan

DRUG

Cabazitaxel

Given IV

DRUG

Carboplatin

Given IV

PROCEDURE

Chest Radiography

Undergo chest x-ray

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

DRUG

Prednisone

Given PO

Trial Locations (174)

18017

RECRUITING

Lehigh Valley Hospital - Muhlenberg, Bethlehem

18103

RECRUITING

Lehigh Valley Hospital-Cedar Crest, Allentown

18201

RECRUITING

Lehigh Valley Hospital-Hazleton, Hazleton

18301

RECRUITING

Pocono Medical Center, East Stroudsburg

19317

RECRUITING

Christiana Care Health System-Concord Health Center, Chadds Ford

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19718

RECRUITING

Christiana Care Health System-Christiana Hospital, Newark

19801

RECRUITING

Christiana Care Health System-Wilmington Hospital, Wilmington

19958

RECRUITING

Beebe Medical Center, Lewes

19967

RECRUITING

Beebe South Coastal Health Campus, Millville

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

21921

RECRUITING

Christiana Care - Union Hospital, Elkton

23235

RECRUITING

VCU Massey Cancer Center at Stony Point, Richmond

23298

RECRUITING

Virginia Commonwealth University/Massey Cancer Center, Richmond

33308

RECRUITING

Holy Cross Hospital, Fort Lauderdale

38138

RECRUITING

The West Clinic - Wolf River, Germantown

39216

RECRUITING

University of Mississippi Medical Center, Jackson

44484

RECRUITING

Saint Joseph Warren Hospital, Warren

44501

RECRUITING

Saint Elizabeth Youngstown Hospital, Youngstown

44512

RECRUITING

Saint Elizabeth Boardman Hospital, Boardman

45005

RECRUITING

Dayton Physicians LLC-Atrium, Franklin

45236

RECRUITING

Oncology Hematology Care Inc-Kenwood, Cincinnati

45331

RECRUITING

Dayton Physicians LLC-Wayne, Greenville

RECRUITING

Wayne Hospital, Greenville

45373

RECRUITING

Dayton Physicians LLC - Troy, Troy

45409

RECRUITING

Greater Dayton Cancer Center, Kettering

45415

RECRUITING

Dayton Physician LLC - Englewood, Dayton

45429

RECRUITING

Kettering Medical Center, Kettering

45431

RECRUITING

Indu and Raj Soin Medical Center, Beavercreek

45459

RECRUITING

Dayton Physicians LLC-Miami Valley South, Centerville

45840

RECRUITING

Armes Family Cancer Center, Findlay

RECRUITING

Blanchard Valley Hospital, Findlay

RECRUITING

Orion Cancer Care, Findlay

47374

RECRUITING

Reid Health, Richmond

48044

RECRUITING

Great Lakes Cancer Management Specialists-Macomb Medical Campus, Macomb

RECRUITING

Henry Ford Warren Hospital - Breast Macomb, Macomb

48054

RECRUITING

Great Lakes Cancer Management Specialists-Doctors Park, East China Township

48093

RECRUITING

Great Lakes Cancer Management Specialists-Macomb Professional Building, Warren

RECRUITING

Henry Ford Madison Heights Hospital - Breast, Warren

RECRUITING

Saint John Macomb-Oakland Hospital, Warren

48106

RECRUITING

Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor

RECRUITING

Huron Gastroenterology PC, Ypsilanti

48114

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton

RECRUITING

Trinity Health Medical Center - Brighton, Brighton

48118

RECRUITING

Chelsea Hospital, Chelsea

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea

48154

RECRUITING

Trinity Health Saint Mary Mercy Livonia Hospital, Livonia

48188

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton

RECRUITING

Trinity Health Medical Center - Canton, Canton

48197

RECRUITING

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti

48236

RECRUITING

Henry Ford Health Saint John Hospital, Detroit

RECRUITING

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center, Grosse Pointe Woods

RECRUITING

Henry Ford Saint John Hospital - Academic, Grosse Pointe Woods

RECRUITING

Henry Ford Saint John Hospital - Breast, Grosse Pointe Woods

48341

RECRUITING

Hope Cancer Center, Pontiac

RECRUITING

Michigan Healthcare Professionals Pontiac, Pontiac

RECRUITING

Newland Medical Associates-Pontiac, Pontiac

RECRUITING

Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac

48346

RECRUITING

Hematology Oncology Consultants-Clarkston, Clarkston

RECRUITING

Newland Medical Associates-Clarkston, Clarkston

48453

RECRUITING

Saint Mary's Oncology/Hematology Associates of Marlette, Marlette

48503

RECRUITING

Genesee Cancer and Blood Disease Treatment Center, Flint

RECRUITING

Genesee Hematology Oncology PC, Flint

RECRUITING

Genesys Hurley Cancer Institute, Flint

RECRUITING

Hurley Medical Center, Flint

48601

RECRUITING

MyMichigan Medical Center Saginaw, Saginaw

48604

RECRUITING

Oncology Hematology Associates of Saginaw Valley PC, Saginaw

48661

RECRUITING

Saint Mary's Oncology/Hematology Associates of West Branch, West Branch

48723

RECRUITING

Caro Cancer Center, Caro

48764

RECRUITING

MyMichigan Medical Center Tawas, Tawas City

48912

RECRUITING

University of Michigan Health - Sparrow Lansing, Lansing

52403

RECRUITING

Mercy Hospital, Cedar Rapids

RECRUITING

Oncology Associates at Mercy Medical Center, Cedar Rapids

54017

RECRUITING

Cancer Center of Western Wisconsin, New Richmond

55008

RECRUITING

Cambridge Medical Center, Cambridge

55082

RECRUITING

Lakeview Hospital, Stillwater

55092

RECRUITING

Fairview Lakes Medical Center, Wyoming

55101

RECRUITING

Regions Hospital, Saint Paul

55102

RECRUITING

United Hospital, Saint Paul

55109

RECRUITING

Minnesota Oncology Hematology PA-Maplewood, Maplewood

RECRUITING

Saint John's Hospital - Healtheast, Maplewood

55125

RECRUITING

Minnesota Oncology Hematology PA-Woodbury, Woodbury

55337

RECRUITING

Minnesota Oncology - Burnsville, Burnsville

55362

RECRUITING

Monticello Cancer Center, Monticello

55369

RECRUITING

Fairview Clinics and Surgery Center Maple Grove, Maple Grove

55371

RECRUITING

Fairview Northland Medical Center, Princeton

55379

RECRUITING

Saint Francis Regional Medical Center, Shakopee

55387

RECRUITING

Ridgeview Medical Center, Waconia

55407

RECRUITING

Abbott-Northwestern Hospital, Minneapolis

55415

RECRUITING

Hennepin County Medical Center, Minneapolis

55416

RECRUITING

Park Nicollet Clinic - Saint Louis Park, Saint Louis Park

55422

RECRUITING

North Memorial Medical Health Center, Robbinsdale

55433

RECRUITING

Mercy Hospital, Coon Rapids

55435

RECRUITING

Fairview Southdale Hospital, Edina

55454

RECRUITING

Health Partners Inc, Minneapolis

56073

RECRUITING

New Ulm Medical Center, New Ulm

56201

RECRUITING

Rice Memorial Hospital, Willmar

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

RECRUITING

Great Falls Clinic, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Kalispell Regional Medical Center, Kalispell

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60611

RECRUITING

Northwestern University, Chicago

60612

RECRUITING

University of Illinois, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

RECRUITING

Valley Radiation Oncology, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

RECRUITING

Western Illinois Cancer Treatment Center, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61636

RECRUITING

Methodist Medical Center of Illinois, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

RECRUITING

HSHS Saint Elizabeth's Hospital, O'Fallon

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Memorial Medical Center, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

62902

RECRUITING

Memorial Hospital of Carbondale, Carbondale

62918

RECRUITING

SIH Cancer Institute, Carterville

63080

RECRUITING

Missouri Baptist Sullivan Hospital, Sullivan

63127

RECRUITING

BJC Outpatient Center at Sunset Hills, Sunset Hills

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

63640

RECRUITING

Parkland Health Center - Farmington, Farmington

63670

RECRUITING

Sainte Genevieve County Memorial Hospital, Sainte Genevieve

63703

RECRUITING

Saint Francis Medical Center, Cape Girardeau

RECRUITING

Southeast Cancer Center, Cape Girardeau

68118

RECRUITING

Nebraska Medicine-Village Pointe, Omaha

68123

RECRUITING

Nebraska Medicine-Bellevue, Bellevue

68198

RECRUITING

University of Nebraska Medical Center, Omaha

72703

RECRUITING

Highlands Oncology Group - Fayetteville, Fayetteville

72758

RECRUITING

Highlands Oncology Group - Rogers, Rogers

72762

RECRUITING

Highlands Oncology Group, Springdale

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

77030

RECRUITING

M D Anderson Cancer Center, Houston

77079

RECRUITING

MD Anderson West Houston, Houston

77384

RECRUITING

MD Anderson in The Woodlands, Conroe

77478

RECRUITING

MD Anderson in Sugar Land, Sugar Land

77573

RECRUITING

MD Anderson League City, League City

82414

RECRUITING

Billings Clinic-Cody, Cody

82801

RECRUITING

Welch Cancer Center, Sheridan

83605

RECRUITING

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83642

RECRUITING

Idaho Urologic Institute-Meridian, Meridian

83687

RECRUITING

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

RECRUITING

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

90822

RECRUITING

Tibor Rubin VA Medical Center, Long Beach

97814

RECRUITING

Saint Alphonsus Cancer Care Center-Baker City, Baker City

97914

RECRUITING

Saint Alphonsus Cancer Care Center-Ontario, Ontario

77026-1967

RECRUITING

Lyndon Baines Johnson General Hospital, Houston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

lead

SWOG Cancer Research Network

NETWORK