Substudy 06C: A Study of Sacituzumab Tirumotecan (MK-2870) With Pembrolizumab (MK-3475) and Chemotherapy in Participants With First-Line Locally Advanced Unresectable/Metastatic Gastroesophageal Adenocarcinoma (MK-3475-06C/KEYMAKER-U06)

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Taipei Veterans General Hospital ( Site 6005), Taipei

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China Medical University Hospital ( Site 6007), Taichung

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National Cheng Kung University Hospital ( Site 6001), Tainan City

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Hôpitaux Universitaires de Genève (HUG) ( Site 6701), Geneva

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Kantonsspital Graubünden-Medizin ( Site 6700), Chur

COMPLETED

Columbia University Irving Medical Center-CUIMC Herbert Irving Comprehensive Cancer Center Clinical ( Site 6907), New York

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National Taiwan University Hospital-Oncology ( Site 6000), Taipei

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Hematology-Oncology Associates of Central NY, P.C. ( Site 6925), East Syracuse

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UPMC Hillman Cancer Center-UPMC ( Site 6904), Pittsburgh

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Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 5200), Milan

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Facharztzentrum Eppendorf-Facharztzentrum Eppendorf ( Site 6807), Hamburg

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CHU-BREST Cavale Blanche ( Site 5104), Brest

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Norton Hospital-Norton Cancer Institute - Downtown ( Site 6900), Louisville

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Universitaetsklinikum Duesseldorf-Gastroenterology, Hepatology and Infectiology ( Site 6802), Düsseldorf

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"IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) Dino Amadori-Oncologia Medica ( Site 5207)", Meldola

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The Cancer and Hematology Centers ( Site 6912), Grand Rapids

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CIC. ( Site 5100), Lille

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Pitie Salpetriere University Hospital-Hepato-Gastro-Enterology ( Site 5102), Paris

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University of Texas MD Anderson Cancer Center ( Site 6920), Houston

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University of Arizona Cancer Center-University of Arizona Cancer Center ( Site 6927), Tucson

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UCLA Hematology/Oncology - Santa Monica ( Site 6905), Los Angeles

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Beijing Cancer hospital-Digestive Oncology ( Site 5500), Beijing

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Fudan University Shanghai Cancer Center ( Site 5513), Shanghai

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Sir Run Run Shaw Hospital of Zhejiang University School of Medicine ( Site 5510), Hangzhou

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The First Affiliated Hospital of Nanchang University ( Site 5514), Nanchang

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The 900th Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army ( Site 5501), Fuzhou

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The First Affiliated hospital of Xiamen University ( Site 5503), Xiamen

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Henan Cancer Hospital ( Site 5504), Zhengzhou

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Xinjiang Medical University Cancer Hospital - Urumqi ( Site 5506), Ürümqi

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Bradford Hill Norte ( Site 6407), Antofagasta

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Centro de Investigación del Maule ( Site 6408), Talca

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Clínica Puerto Montt ( Site 6409), Port Montt

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FALP-UIDO ( Site 6400), Santiago

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Centro de Oncología de Precisión-Oncology ( Site 6404), Santiago

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Clínica UC San Carlos de Apoquindo ( Site 6405), Santiago

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Bradfordhill-Clinical Area ( Site 6401), Santiago

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Liga Norte Riograndense Contra o Câncer ( Site 6303), Natal

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Hospital Nossa Senhora da Conceição ( Site 6301), Porto Alegre

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IBCC - Instituto Brasileiro de Controle do Câncer ( Site 6304), São Paulo

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Oslo universitetssykehus, Radiumhospitalet ( Site 6501), Oslo

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Asan Medical Center-Department of Oncology ( Site 5901), Seoul

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Samsung Medical Center-Division of Hematology/Oncology ( Site 5900), Seoul