NCT06467461View on ClinicalTrials.gov

Identification of Prodromal Neurodegeneration in Serotonergic-Induced REM Sleep Behavior Disorder

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 8, 2024

Primary Completion Date

December 1, 2027

Study Completion Date

September 1, 2028

Conditions
Dementia With Lewy BodiesParkinson DiseaseREM Sleep Behavior Disorder
Interventions
DIAGNOSTIC_TEST

Skin biopsy

Skin biopsy to detect systemic alpha-synuclein pathology in 5-HT RBD

DIAGNOSTIC_TEST

Speech testing

Speech Testing to quantify evolving signs of 5-HT RBD

DIAGNOSTIC_TEST

Ultra high field 7T MRI

7T MRI to examine 5-HT RBD for evidence of brainstem neurodegeneration

Trial Locations (1)

55455

RECRUITING

University of Minnesota, Minneapolis

All Listed Sponsors
lead

University of Minnesota

OTHER