The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

March 25, 2024

Primary Completion Date

May 31, 2024

Study Completion Date

May 31, 2024

Conditions
Septic ShockSepsis
Interventions
DRUG

Norepinephrine

NE Group (Fluid loading with early norepinephrine administration group) NE Group will receive ringer lactate bolus 20 ml/kg along with norepinephrine infusion at 0.1 mcg/kg/minute until MAP\>5 percentile. Additional fluid boluses of 10-20 ml/kg will be administered (up to a total of 60 ml/kg) until shock resolution or signs of fluid overload are observed, with or without continued norepinephrine infusion according to the treatment group

DRUG

Ringer's Lactate

Fluid Group will receive ringer lactate bolus 20 ml/ kg only. Additional fluid boluses of 10-20 ml/kg will be administered (up to a total of 60 ml/kg) until shock resolution or signs of fluid overload are observed

Trial Locations (1)

10440

Cipto Mangunkusumo Hospital, Jakarta Pusat

All Listed Sponsors
lead

Indonesia University

OTHER

NCT06461390 - The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic Shock | Biotech Hunter | Biotech Hunter