A Study to Compare Sacituzumab Tirumotecan (MK-2870) Monotherapy Versus Treatment of Physician's Choice as Second-line Treatment for Participants With Recurrent or Metastatic Cervical Cancer (MK-2870-020/TroFuse-020/Gog-3101/ENGOT-cx20)

PHASE3RecruitingINTERVENTIONAL
Enrollment

686

Participants

Timeline

Start Date

July 24, 2024

Primary Completion Date

October 23, 2028

Study Completion Date

October 23, 2028

Conditions
Cervical Cancer
Interventions
BIOLOGICAL

Sacituzumab Tirumotecan

IV infusion

DRUG

Pemetrexed

IV infusion

BIOLOGICAL

Tisotumab Vedotin

IV infusion

DRUG

Topotecan

IV infusion

DRUG

Vinorelbine

IV infusion

DRUG

Gemcitabine

IV infusion

DRUG

Irinotecan

IV infusion

Trial Locations (219)

1090

RECRUITING

Medizinische Universität Wien ( Site 1001), Vienna

2100

RECRUITING

Rigshospitalet-Dept. of Oncology ( Site 1300), Copenhagen

2148

RECRUITING

Blacktown Hospital ( Site 3006), Sydney

2560

RECRUITING

Campbelltown Hospital-Macarthur Cancer Therapy Centre Medical Oncology ( Site 3000), Sydney

3000

COMPLETED

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 3005), Melbourne

RECRUITING

UZ Leuven-Gynecologic Oncology ( Site 2900), Leuven

3010

RECRUITING

Inselspital Bern-Oncology ( Site 2700), Bern

3168

RECRUITING

Monash Health-Oncology Research ( Site 3002), Clayton

4000

RECRUITING

Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman-Medical Oncology ( Site 2904), Belgium

4004

RECRUITING

Complex Oncology Center - Plovdiv EOOD ( Site 1102), Plovdiv

4020

RECRUITING

Kepler Universitätsklinikum-Department for Oncology and Hematology ( Site 1002), Linz

4029

RECRUITING

Royal Brisbane and Women's Hospital ( Site 3001), Herston

4031

RECRUITING

University Hospital Basel-Gynecology & Gynecologic Oncology ( Site 2701), Basel

4500

RECRUITING

MBAL Uni Hospital-Department of Medical Oncology ( Site 1104), Panagyurishte

5000

RECRUITING

Sanatorio Allende - Cerro-Oncology ( Site 0106), Córdoba

RECRUITING

CHU UCL Namur/Site Sainte Elisabeth-Trial Office ( Site 2902), Namur

RECRUITING

Odense Universitetshospital-Department of oncology ( Site 1302), Odense C

5804

RECRUITING

MHAT - Heart and Brain ( Site 1100), Pleven

6009

RECRUITING

Sir Charles Gairdner Hospital ( Site 3003), Nedlands

6020

RECRUITING

Medizinische Universitaet Innsbruck-Univ.-Klinik f. Gynäkologie und Geburtshilfe ( Site 1000), Innsbruck

8036

RECRUITING

Medizinische Universität Graz-Abteilung für Gynäkologie / Onkologie ( Site 1003), Graz

8200

RECRUITING

Aarhus Universitetshospital, Skejby ( Site 1301), Aarhus

9000

RECRUITING

UZ Gent-Medical oncology ( Site 2901), Ghent

9300

RECRUITING

AZORG Campus Aalst-Moorselbaan ( Site 2905), Aalst

10128

RECRUITING

Ospedale Mauriziano-SCDU ONCOLOGIA MEDICA ( Site 2100), Turin

10350

RECRUITING

Penang Adventist Hospital ( Site 3101), Pulau Pinang

13009

RECRUITING

Institut Paoli-Calmettes ( Site 1504), Marseille

14004

RECRUITING

Hospital Universitario Reina Sofia-Oncologia Medica ( Site 2501), Córdoba

17007

RECRUITING

Institut Català d'Oncologia (ICO) - Girona-Oncología Médica ( Site 2507), Girona

19090

RECRUITING

Asplundh Cancer Pavilion ( Site 4113), Willow Grove

19107

RECRUITING

Sidney Kimmel Cancer Center - Jefferson Health ( Site 4142), Philadelphia

20089

RECRUITING

Humanitas University ( Site 2112), Rozzano

20132

RECRUITING

Ospedale San Raffaele. ( Site 2106), Milan

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Chirurgia Ginecologica ( Site 2107), Milan

20141

RECRUITING

Istituto Europeo di Oncologia IRCCS ( Site 2108), Milan

20159

RECRUITING

Ospedale Humanitas San Pio X ( Site 2113), Milan

20520

RECRUITING

Turku University Hospital-Department of Obstetrics and Gynecology ( Site 1401), Turku

20900

RECRUITING

Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 2111), Monza

22190

RECRUITING

Hôpital Privé Des Côtes d'Armor ( Site 1510), Plérin

22908

RECRUITING

University of Virginia Cancer Center ( Site 4123), Charlottesville

25030

RECRUITING

CHU Besançon ( Site 1507), Besançon

25123

RECRUITING

Azienda Ospedaliera Spedali Civili di Brescia-Obstetrics anf gynecology ( Site 2110), Brescia

27710

RECRUITING

Duke Cancer Institute ( Site 4120), Durham

28027

RECRUITING

Clinica Universidad de Navarra ( Site 2510), Madrid

28034

RECRUITING

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 2502), Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 2506), Madrid

28046

RECRUITING

Hospital Universitario La Paz-Oncología Médica ( Site 2504), Madrid

30342

RECRUITING

Northside Hospital ( Site 4127), Atlanta

30912

RECRUITING

Georgia Cancer Center at Augusta University ( Site 4112), Augusta

31059

RECRUITING

Oncopole Claudius Regaud ( Site 1502), Toulouse

31405

RECRUITING

Lewis Cancer and Research Pavilion ( Site 4114), Savannah

32804

RECRUITING

Advent Health ( Site 4140), Orlando

33076

RECRUITING

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1503), Bordeaux

33140

RECRUITING

Mount Sinai Comprehensive Cancer Center ( Site 4143), Miami Beach

33401

RECRUITING

Florida Cancer Specialists East ( Site 7001), West Palm Beach

33520

RECRUITING

Tampereen yliopistollinen sairaala-Gynecology and Obstetrics ( Site 1404), Tampere

34298

RECRUITING

Institut Regional du Cancer Montpellier ( Site 1511), Montpellier

35128

RECRUITING

Istituto Oncologico Veneto IRCCS ( Site 2109), Padua

36604

RECRUITING

USA Mitchell Cancer Institute-Clinical Trials ( Site 4126), Mobile

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlin-DEPARTMENT OF EXPERIMENTAL, DIAGNOSTIC ( Site 2105), Bologna

43026

RECRUITING

The Ohio State University ( Site 4103), Hilliard

44277

RECRUITING

Hôpital privé du Confluent SAS ( Site 1509), Nantes

45136

RECRUITING

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung-Klinik für Gynäkologie und Gynäkologische Onko ( Site 1600), Essen

45219

RECRUITING

University of Cincinnati Medical Center ( Site 4128), Cincinnati

46009

RECRUITING

Fundación Instituto Valenciano de Oncología-Oncologico ( Site 2503), Valencia

46010

RECRUITING

HOSPITAL CLINICO DE VALENCIA ( Site 2505), Valencia

47500

RECRUITING

Sunway Medical Centre ( Site 3105), Petaling Jaya

59100

RECRUITING

University Malaya Medical Centre ( Site 3102), Lembah Pantai

RECRUITING

Pantai Hospital Kuala Lumpur ( Site 3100), Kuala Lumpur

63011

RECRUITING

Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 1508), Clermont-Ferrand

66421

RECRUITING

Universitaetsklinikum des Saarlandes ( Site 1618), Homburg

67200

RECRUITING

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1501), Strasbourg

69373

RECRUITING

CENTRE LEON BERARD ( Site 1505), Lyon Cedex08

70112

RECRUITING

University Medical Center New Orleans ( Site 4132), New Orleans

71103

RECRUITING

Willis Knighton Medical Center ( Site 4101), Shreveport

74146

RECRUITING

Oklahoma Cancer Specialists and Research Institute, LLC-Clinical Research ( Site 4116), Tulsa

75020

RECRUITING

Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1506), Paris

76104

RECRUITING

Texas Oncology - DFW ( Site 8003), Fort Worth

77030

RECRUITING

Houston Methodist Hospital OB/GYN ( Site 4102), Houston

78240

RECRUITING

Texas Oncology - San Antonio ( Site 8006), San Antonio

80131

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 2103), Napoli

85016

RECRUITING

HonorHealth (HH) ( Site 8002), Phoenix

85711

RECRUITING

Arizona Oncology Associates - HOPE ( Site 8001), Tucson

87109

RECRUITING

Optimum Clinical Research Group ( Site 4138), Albuquerque

89511

RECRUITING

The Center of Hope ( Site 4106), Reno

90095

RECRUITING

UCLA Hematology/Oncology - Westwood (Building 100)-Department of OBGYN, Division of Gynecologic Onc ( Site 4105), Los Angeles

92093

RECRUITING

Moores Cancer Center-Clinical Trials Office - Gynecological Oncology ( Site 4125), La Jolla

92663

RECRUITING

Hoag Memorial Hospital Presbyterian ( Site 4104), Newport Beach

94805

RECRUITING

Gustave Roussy ( Site 1512), Villejuif

95126

RECRUITING

Ospedale Cannizzaro ( Site 2104), Catania

97210

RECRUITING

Legacy Good Samaritan Medical Center-Oncology Clinical Research ( Site 4115), Portland

97401

RECRUITING

Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007), Eugene

98104

RECRUITING

Swedish Medical Center-Swedish Cancer Institute ( Site 4134), Seattle

99508

RECRUITING

Providence Alaska Medical Center ( Site 4137), Anchorage

100730

RECRUITING

Beijing Peking Union Medical College Hospital ( Site 5045), Beijing

110131

RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0403), Bogotá

111151

RECRUITING

Instituto Nacional De Cancerologia-Oncología Clínica ( Site 0404), Bogota

119228

RECRUITING

National University Hospital ( Site 3301), Singapore

130000

RECRUITING

Jilin Province Tumor Hospital ( Site 5036), Changchun

150000

RECRUITING

Harbin Medical University Cancer Hospital ( Site 5010), Harbin

168583

RECRUITING

National Cancer Centre Singapore ( Site 3300), Singapore

200001

RECRUITING

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0401), Valledupar

200011

RECRUITING

Obstetrics & Gynecology Hospital of Fudan University ( Site 5015), Shanghai

210036

RECRUITING

Jiangsu Province Hospital-Oncology Department ( Site 5018), Nanjing

230000

RECRUITING

Anhui Provincial Cancer Hospital-Gynecological Oncology ( Site 5040), Hefei

230002

COMPLETED

IMAT S.A.S ( Site 0402), Montería

230071

RECRUITING

Anhui Provincial Hospital ( Site 5011), Hefei

250117

RECRUITING

Shandong Cancer Hospital ( Site 5014), Jinan

276000

RECRUITING

LinYi Cancer Hospital-Gastrology department ( Site 5039), Linyi

310006

RECRUITING

Women s Hospital School of Medicine Zhejiang University ( Site 5022), Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital ( Site 5008), Hangzhou

325015

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University ( Site 5033), Wenzhou

330077

RECRUITING

Jiangxi Maternal and Child Health Hospital ( Site 5031), Nanchang

350014

RECRUITING

Fujian Provincial Cancer Hospial ( Site 5012), Fuzhou

361003

RECRUITING

The First Affiliated hospital of Xiamen University-Obstetrics and gynecology department ( Site 5027), Xiamen

400030

RECRUITING

Chongqing University Cancer Hospital ( Site 5003), Chongqing

410013

RECRUITING

Hunan Cancer Hospital ( Site 5021), Changsha

410028

RECRUITING

Xiangya Hospital Central South University ( Site 5009), Changsha

430048

RECRUITING

Wuhan Union Hospital ( Site 5020), Wuhan

430079

RECRUITING

Hubei Cancer Hospital-Hubei Cancer Hospital ( Site 5019), Wuhan

450008

RECRUITING

Henan Cancer Hospital ( Site 5026), Zhengzhou

453100

RECRUITING

The First Affiliated Hospital of Xinxiang Medical University-Oncology ( Site 5041), Xinxiang

510000

RECRUITING

Sun Yat-sen Memorial Hospital, Sun Yat-sen University ( Site 5001), Guangzhou

511400

RECRUITING

Sun Yat-sen University Cancer Center-Internal medicine ( Site 5006), Guangzhou

524004

RECRUITING

Affiliated Hospital of Guangdong Medical University ( Site 5004), Zhanjiang

530200

RECRUITING

Guangxi Medical University Affiliated Tumor Hospital ( Site 5016), Nanning

570311

RECRUITING

Hainan General Hospital ( Site 5032), Haikou

610000

RECRUITING

West China Second University Hospital, Sichuan University ( Site 5017), Chengdu

610042

RECRUITING

Sichuan Cancer hospital-Oncology ( Site 5030), Chengdu

650107

RECRUITING

Yunnan Province Cancer Hospital-Gynecology Department ( Site 5005), Kunming

660001

RECRUITING

Oncologos del Occidente ( Site 0405), Pereira

710061

RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University ( Site 5007), Xi'an

760032

RECRUITING

Fundación Valle del Lili ( Site 0406), Santiago de Cali

2520598

RECRUITING

ONCOCENTRO APYS-ACEREY ( Site 0303), Viña del Mar

3109601

RECRUITING

Rambam Health Care Campus ( Site 2002), Haifa

5265601

RECRUITING

Sheba Medical Center ( Site 2001), Ramat Gan

5810001

RECRUITING

Edith Wolfson Medical Center ( Site 2003), Holon

7500921

RECRUITING

FALP-UIDO ( Site 0300), Santiago

8330024

RECRUITING

Pontificia Universidad Catolica de Chile ( Site 0302), Santiago

9112001

RECRUITING

Hadassah Medical Center ( Site 2000), Jerusalem

80510130

RECRUITING

Instituto do Câncer e Transplante de Curitiba ( Site 0205), Curitiba

07666

RECRUITING

Holy Name Medical Center ( Site 4117), Teaneck

22031-4867

RECRUITING

Inova Schar Cancer Institute ( Site 4139), Fairfax

C1280AEB

RECRUITING

Hospital Británico de Buenos Aires-Oncology ( Site 0102), Ciudad Autónoma de Buenos Aires

B7600FZO

RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0107), Mar del Plata

C1417

RECRUITING

Instituto de Oncología Angel H. Roffo ( Site 0103), Buenos Aires

C1426ANZ

RECRUITING

Instituto Alexander Fleming ( Site 0108), Buenos Aires

C1118AAT

RECRUITING

Hospital Aleman-Oncology ( Site 0100), Buenos Aires

C1431FWO

RECRUITING

Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0109), CABA

F5300COE

RECRUITING

Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0104), La Rioja

90035-001

RECRUITING

Hospital Moinhos de Vento-Centro de Pesquisa Clínica ( Site 0204), Porto Alegre

90110-270

RECRUITING

Hospital do Câncer Mãe de Deus ( Site 0201), Porto Alegre

89202-050

RECRUITING

Centro de Hematologia e Oncologia ( Site 0203), Joinville

04014-002

RECRUITING

IBCC - Instituto Brasileiro de Controle do Câncer-Centro de Pesquisa Clínica ( Site 0200), São Paulo

22775-001

RECRUITING

Americas Centro de Oncologia Integrado ( Site 0202), Rio de Janeiro

01321-001

RECRUITING

Hospital Paulistano ( Site 0209), São Paulo

V1Y 5L3

RECRUITING

BC Cancer Kelowna ( Site 4007), Kelowna

V3V 1Z2

RECRUITING

BC Cancer Surrey ( Site 4006), Surrey

V8R 6V5

RECRUITING

BC Cancer Victoria ( Site 4008), Victoria

L4M 6M2

RECRUITING

Royal Victoria Regional Health Centre ( Site 4009), Barrie

L8V 5C2

RECRUITING

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 4003), Hamilton

H2X 0C1

RECRUITING

Centre Hospitalier de l'Université de Montréal ( Site 4001), Montreal

H4A 3J1

RECRUITING

McGill University Health Centre ( Site 4000), Montreal

G1J 1Z4

RECRUITING

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 4002), Québec

030000

RECRUITING

Shanxi Cancer Hospital ( Site 5043), Taiyuan

00029

RECRUITING

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 1400), Helsinki

115 28

RECRUITING

Aretaieio Hospital ( Site 1700), Athens

151 23

RECRUITING

Mitera Hospital ( Site 1702), Athens

124 62

RECRUITING

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1703), Chaïdári

263 35

RECRUITING

Agios Andreas Hospital Patras ( Site 1701), Patras

T12 E8YV

RECRUITING

Cork University Hospital ( Site 1900), Cork

D07 R2WY

RECRUITING

Mater Misericordiae University Hospital ( Site 1901), Dublin

D08 E9P6

RECRUITING

St. James's Hospital-Cancer clinical trials office ( Site 1902), Dublin

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2102), Roma

464-8681

RECRUITING

Aichi Cancer Center ( Site 5110), Nagoya

277-8577

RECRUITING

National Cancer Center Hospital East ( Site 5113), Kashiwa

791-0280

RECRUITING

National Hospital Organization Shikoku Cancer Center ( Site 5109), Matsuyama

791-0295

RECRUITING

Ehime University Hospital ( Site 5102), Tōon

830-0011

RECRUITING

Kurume University Hospital ( Site 5105), Kurume

373-8550

RECRUITING

Gunma Prefectural Cancer Center ( Site 5116), Ohta

060-8648

RECRUITING

Hokkaido University Hospital ( Site 5106), Sapporo

305-8576

RECRUITING

University of Tsukuba Hospital ( Site 5114), Tsukuba

028-3695

RECRUITING

Iwate Medical University Hospital ( Site 5112), Shiwa-gun

350-1298

RECRUITING

Saitama Medical University International Medical Center ( Site 5117), Hidaka

411-8777

RECRUITING

Shizuoka Cancer Center ( Site 5107), Sunto-gun,

104-0045

RECRUITING

National Cancer Center Hospital ( Site 5108), Chūō

135-8550

RECRUITING

Cancer Institute Hospital of JFCR ( Site 5111), Koto

160-8582

RECRUITING

Keio University Hospital ( Site 5101), Shinjyuku

811-1395

RECRUITING

National Hospital Organization Kyushu Cancer Center ( Site 5104), Fukuoka

890-8760

RECRUITING

Kagoshima City Hospital ( Site 5115), Kagoshima

951-8566

RECRUITING

Niigata Cancer Center Hospital ( Site 5100), Niigata

541-8567

RECRUITING

Osaka International Cancer Institute ( Site 5103), Osaka

6525 GA

RECRUITING

Radboudumc-Medical Oncology ( Site 2202), Nijmegen

5623 EJ

RECRUITING

Catharina Ziekenhuis-Oncology ( Site 2203), Eindhoven

1081 HV

RECRUITING

Amsterdam UMC, locatie VUmc ( Site 2201), Amsterdam

3015 GD

RECRUITING

Erasmus Medisch Centrum-Medical Oncology ( Site 2200), Rotterdam

9713GZ

RECRUITING

University Medical Center Groningen ( Site 2204), Groningen

0379

RECRUITING

Oslo universitetssykehus, Radiumhospitalet ( Site 2300), Oslo

60-569

RECRUITING

Uniwersytecki Szpital Kliniczny w Poznaniu-Oddzial Ginekologii Onkologicznej ( Site 2404), Poznan

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 2400), Warsaw

15-027

RECRUITING

Bialostockie Centrum Onkologii-Oddzial Onkologii Ginekologicznej ( Site 2402), Bialystok

00935

RECRUITING

UPR Comprehensive Cancer Center-Comprehensive Cancer Center Hospital ( Site 0601), San Juan

03080

RECRUITING

Seoul National University Hospital ( Site 3403), Seoul

03722

RECRUITING

Severance Hospital, Yonsei University Health System ( Site 3402), Seoul

05505

RECRUITING

Asan Medical Center-Division of Gynecologic Oncology, Dept. of Obstetrics & Gynecology ( Site 3401), Seoul

06351

RECRUITING

Samsung Medical Center ( Site 3400), Seoul

08036

RECRUITING

HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 2509), Barcelona

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 2508), L'Hospitalet de Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 2500), Barcelona

221 85

RECRUITING

Skånes Universitetssjukhus Lund-Department of Hematology ( Site 2602), Lund

171 64

RECRUITING

Karolinska Universitetssjukhuset Solna ( Site 2601), Stockholm

751 85

RECRUITING

Akademiska sjukhuset ( Site 2603), Uppsala

581 85

RECRUITING

Universitetssjukhuset i Linköping ( Site 2600), Linköping

SW10 9NH

RECRUITING

ROYAL MARSDEN HOSPITAL (CHELSEA)-Gynaecology Research Centre ( Site 2807), London

SM2 5PT

RECRUITING

Royal Marsden Hospital (Sutton)-Gynaecology Unit ( Site 2801), Sutton

G12 0YN

RECRUITING

Gartnavel General Hospital-Clinical Trials Unit ( Site 2800), Glasgow

NW1 2PG

RECRUITING

University College London Hospital ( Site 2805), London

LS9 7TF

RECRUITING

St James's University Hospital ( Site 2804), Leeds

m20 4bx

RECRUITING

The Christie NHS Foundation Trust-Research and Development ( Site 2802), Manchester

All Listed Sponsors
collaborator

European Network of Gynaecological Oncological Trial Groups (ENGOT)

OTHER

collaborator

GOG Foundation

NETWORK

lead

Merck Sharp & Dohme LLC

INDUSTRY