Bomedemstat vs Hydroxyurea for Essential Thrombocythemia (MK-3543-007)

PHASE3RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

July 16, 2024

Primary Completion Date

September 28, 2027

Study Completion Date

April 15, 2029

Conditions
Essential Thrombocythemia
Interventions
DRUG

Bomedemstat

Oral capsule

DRUG

Hydroxyurea

Oral capsule

DRUG

Bomedemstat placebo

Oral capsule placebo

DRUG

Hydroxyurea placebo

Oral capsule placebo

Trial Locations (137)

613

RECRUITING

Chang Gung Memorial Hospital- Chiayi ( Site 0242), Chiayi City

704

RECRUITING

National Cheng Kung University Hospital-Clinical Trial Center ( Site 0245), Tainan City

2100

RECRUITING

Rigshospitalet-Hematology - CTU ( Site 0321), Copenhagen

2115

RECRUITING

Westmead Hospital ( Site 0201), Westmead

3084

RECRUITING

Austin Health-Cancer Clinical Trials Centre ( Site 0206), Heidelberg

3168

RECRUITING

Monash Health-Haematology Research ( Site 0202), Clayton

4000

RECRUITING

Roskilde Sygehus-Department of Hematology ( Site 0323), Roskilde

4020

RECRUITING

Ordensklinikum Linz GmbH Elisabethinen ( Site 0562), Linz

4032

RECRUITING

Debreceni Egyetem Klinikai Kozpont-Belgyógyászati Klinika (Haematologia) ( Site 0402), Debrecen

4400

RECRUITING

Szabolcs-Szatmár-Bereg Megyei Kórházak és Egyetemi Oktatókór-Haematológia osztály ( Site 0404), Nyíregyháza

5000

RECRUITING

Royal Adelaide Hospital-Haematology Clinical Trials Unit ( Site 0203), Adelaide

RECRUITING

Odense Universitetshospital-Department of Hematology ( Site 0325), Odense C

6000

RECRUITING

Royal Perth Hospital-Haematology ( Site 0204), Perth

6725

RECRUITING

Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 0407), Szeged

7400

RECRUITING

Somogy Vármegyei Kaposi Mór Oktató Kórház-Haematológiai osztály ( Site 0406), Kaposvár

8200

RECRUITING

Aarhus Universitetshospital, Skejby-Blodsygdomme ( Site 0324), Aarhus

9024

RECRUITING

Petz Aladar Egyetemi Oktato Korhaz-Hematológia ( Site 0405), Győr

10002

RECRUITING

National Taiwan University Hospital ( Site 0241), Taipei

11819

RECRUITING

Higiea Oncologia ( Site 0184), Mexico City

13005

RECRUITING

Hôpital de la Conception ( Site 0351), Marseille

13353

RECRUITING

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0369), Berlin

15121

RECRUITING

Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo ( Site 0443), Alessandria

20122

RECRUITING

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico ( Site 0447), Milan

21100

RECRUITING

Ospedale di Circolo e Fondazione Macchi Varese ( Site 0442), Varese

22030

RECRUITING

Trakya University Medical Faculty Hospital-Hematology ( Site 0501), Edirne

22185

RECRUITING

Skånes Universitetssjukhus Lund-Department of Hematology ( Site 0544), Lund

22908

RECRUITING

University of Virginia ( Site 0020), Charlottesville

23219

RECRUITING

VCU Health Adult Outpatient Pavillion ( Site 0008), Richmond

27100

RECRUITING

Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 0444), Pavia

27157

RECRUITING

Wake Forest Baptist Health-Internal Medicine, Section on Hematology & Oncology ( Site 0013), Winston-Salem

27710

RECRUITING

Duke University Health System (DUHS) ( Site 0012), Durham

28027

RECRUITING

Clinica Universidad de Navarra-Hematology Department ( Site 0485), Madrid

28034

RECRUITING

Hospital Universitario Ramón y Cajal-Hematology ( Site 0484), Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre ( Site 0494), Madrid

28204

RECRUITING

Levine Cancer Institute ( Site 0009), Charlotte

29603

RECRUITING

Hospital Costa del Sol-Hematology Service ( Site 0493), Marbella

30625

RECRUITING

Medizinische Hochschule Hannover ( Site 0371), Hanover

31059

RECRUITING

Institut Universitaire du Cancer Toulouse - Oncopole - CHU de TOULOUSE ( Site 0352), Toulouse

31203

RECRUITING

Medivest Centro de Investigación Integral ( Site 0183), Chihuahua City

33305

RECRUITING

Chang Gung Medical Foundation-Linkou Branch ( Site 0243), Taoyuan District

33600

RECRUITING

CHU Bordeaux Haut-Leveque-service de mèdecine interne et maladies infectieuses ( Site 0346), Pessac

34214

RECRUITING

Medipol Mega Universite Hastanesi ( Site 0504), Istanbul

35100

RECRUITING

Ege Universitesi Hastanesi ( Site 0503), Izmir

37000

RECRUITING

Centre Hospitalier Régional Universitaire de Tours - Hôpital-Hématologie et Thérapie Cellulaire ( Site 0342), Tours

37007

RECRUITING

Hospital Universitario de Salamanca - Complejo Asistencial Universitario de Salamanca-Hematology ( Site 0488), Salamanca

39008

RECRUITING

Hospital Universitario Marqués de Valdecilla-Haematology ( Site 0486), Santander

40138

RECRUITING

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 0446), Bologna

41380

RECRUITING

Kocaeli Üniversitesi-Hematology ( Site 0506), Kocaeli

43210

RECRUITING

The Ohio State University Wexner Medical Center ( Site 0028), Columbus

44000

RECRUITING

Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu ( Site 0347), Nantes

45147

RECRUITING

Universitaetsklinikum Essen ( Site 0366), Essen

46845

COMPLETED

Parkview Research Center at Parkview Regional Medical Center ( Site 0006), Fort Wayne

48109

RECRUITING

University of Michigan ( Site 0003), Ann Arbor

50134

RECRUITING

Azienda Ospedaliera Universitaria Careggi ( Site 0441), Florence

52074

RECRUITING

Universitätsklinikum Aachen ( Site 0367), Aachen

55131

RECRUITING

Universitätsmedizin Johannes Gutenberg Universität Mainz-3. Medizinische Klinik und Poliklinik ( Site 0365), Mainz

55139

RECRUITING

Ondokuz Mayıs Universitesi-hematology ( Site 0507), Samsun

68020

RECRUITING

Centro de Investigacion Clinica de Oaxaca ( Site 0181), Oaxaca City

69310

RECRUITING

centre hospitalier lyon sud ( Site 0343), Pierre-Bénite

75010

RECRUITING

Hopital Saint-Louis ( Site 0341), Paris

77030

RECRUITING

University of Texas MD Anderson Cancer Center ( Site 0026), Houston

78229

RECRUITING

University of Texas Health Science Center at San Antonio ( Site 0021), San Antonio

80401

RECRUITING

Exempla Lutheran Medical Center ( Site 0014), Golden

84036

RECRUITING

VK&K Studien GbR ( Site 0370), Landshut

87042

RECRUITING

Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 0344), Limoges

91206

RECRUITING

Los Angeles Cancer Network ( Site 0025), Glendale

94010

RECRUITING

HENRI MONDOR HOSPITAL ( Site 0348), Créteil

94304

RECRUITING

Stanford Cancer Center ( Site 0024), Palo Alto

97239

RECRUITING

Oregon Health & Science University ( Site 0018), Portland

110121

RECRUITING

Los Cobos Medical Center ( Site 0165), Bogotá

230002

RECRUITING

IMAT S.A.S ( Site 0162), Montería

1720430

RECRUITING

IC La Serena Research ( Site 0150), La Serena

2201202

RECRUITING

Galilee Medical Center ( Site 0431), Nahariya

3109601

RECRUITING

Rambam Health Care Campus ( Site 0429), Haifa

3436212

RECRUITING

Carmel Hospital ( Site 0426), Haifa

4070196

RECRUITING

Biocenter ( Site 0149), Concepción

4941492

RECRUITING

Rabin Medical Center ( Site 0425), Petah Tikva

5265601

RECRUITING

Sheba Medical Center ( Site 0428), Ramat Gan

6423906

RECRUITING

Sourasky Medical Center ( Site 0422), Tel Aviv

7033001

RECRUITING

Yitzhak Shamir Medical Center. ( Site 0421), Ẕerifin

7500921

RECRUITING

FALP-UIDO ( Site 0148), Santiago

7580206

RECRUITING

Clínica Inmunocel ( Site 0147), Santiago

7650568

RECRUITING

Clínica Alemana de Santiago ( Site 0143), Santiago

8410101

RECRUITING

Soroka Medical Center ( Site 0427), Beersheba

8420383

RECRUITING

Bradfordhill-Clinical Area ( Site 0142), Santiago

9112001

RECRUITING

Hadassah Medical Center ( Site 0424), Jerusalem

B1629AHJ

RECRUITING

Hospital Universitario Austral ( Site 0101), Pilar

C1199ABB

RECRUITING

Hospital Italiano de Buenos Aires ( Site 0102), ABB

T4000IKO

RECRUITING

C.I.C.E. 9 de Julio ( Site 0104), San Miguel de Tucumán

S3000BPJ

RECRUITING

Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0105), Santa Fe

J4V 2H1

RECRUITING

Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0037), Greenfield Park

050030

RECRUITING

Fundacion Colombiana de Cancerología Clinica Vida ( Site 0164), Medellín

06202

RECRUITING

Centre Hospitalier Universitaire de Nice - Hôpital l'Archet-Hematology ( Site 0349), Nice

06120

RECRUITING

Universitätsklinikum Halle ( Site 0361), Halle

07747

RECRUITING

Universitätsklinikum Jena-Klinik für Innere Medizin II, Abt. Hämatologie und Internistische Onkolog ( Site 0364), Jena

Unknown

RECRUITING

Queen Mary Hospital ( Site 0221), Hksar

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 0445), Roma

470-1192

RECRUITING

Fujita Health University Hospital ( Site 0613), Toyoake

791-0295

RECRUITING

Ehime University Hospital ( Site 0612), Tōon

060-8648

RECRUITING

Hokkaido University Hospital ( Site 0601), Sapporo

650-0047

RECRUITING

Kobe City Medical Center General Hospital ( Site 0603), Kobe

920-8641

RECRUITING

Kanazawa University Hospital ( Site 0614), Kanazawa

514-8507

RECRUITING

Mie University Hospital ( Site 0615), Tsu

983-8520

RECRUITING

National Hospital Organization Sendai Medical Center ( Site 0617), Sendai

573-1191

RECRUITING

Kansai Medical University Hospital ( Site 0607), Hirakata

589-8511

RECRUITING

Kindai University Hospital ( Site 0600), Sayama

113-8431

RECRUITING

Juntendo University Hospital ( Site 0611), Bunkyo-ku

409-3898

RECRUITING

University of Yamanashi Hospital ( Site 0606), Chūō

812-8582

RECRUITING

Kyushu University Hospital ( Site 0605), Fukuoka

960-1295

RECRUITING

Fukushima Medical University Hospital ( Site 0616), Fukushima

889-1692

RECRUITING

University of Miyazaki Hospital ( Site 0609), Miyazaki

700-8558

RECRUITING

Okayama University Hospital ( Site 0604), Okayama

113-8603

RECRUITING

Nippon Medical School Hospital ( Site 0608), Tokyo

20-081

RECRUITING

Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie-Oddział Hematoonkologii, Transplantacji Szp ( Site 0463), Lublin

40-519

RECRUITING

Pratia Onkologia Katowice ( Site 0461), Katowice

25-734

RECRUITING

Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Hematologii i Transplantacji S ( Site 0466), Kielce

08916

RECRUITING

Hospital Germans Trias i Pujol-Instituto Catalán de Oncología de Badalona ( Site 0490), Badalona

08036

RECRUITING

HOSPITAL CLÍNIC DE BARCELONA ( Site 0481), Barcelona

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet ( Site 0482), L'Hospitalet de Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 0489), Barcelona

141 86

RECRUITING

Karolinska Universitetssjukhuset Huddinge ( Site 0541), Huddinge

751 85

RECRUITING

Akademiska sjukhuset ( Site 0545), Uppsala

413 45

RECRUITING

Sahlgrenska Universitetssjukhuset-Department of hematology and coagulation ( Site 0543), Gothenburg

701 85

RECRUITING

Universitetssjukhuset Örebro ( Site 0542), Örebro

06200

RECRUITING

Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi-Hemotology ( Site 0510), Ankara

06230

RECRUITING

Hacettepe Universite Hastaneleri-Department of Hematology ( Site 0505), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 0502), Ankara

07100

RECRUITING

Antalya Egitim ve Arastırma Hastanesi ( Site 0508), Antalya

LL18 5UJ

RECRUITING

Glan Clwyd Hospital ( Site 0528), Bodelwyddan

GL1 3NN

RECRUITING

Gloucestershire Royal Hospital ( Site 0521), Gloucester

LN2 5QY

RECRUITING

Lincoln County Hospital ( Site 0535), Lincoln

PE21 9QS

RECRUITING

Boston Pilgrim Hospital ( Site 0525), Boston

NW1 2PG

RECRUITING

University College London Hospital ( Site 0527), London

SE1 9RT

RECRUITING

Guy's & St Thomas' NHS Foundation Trust ( Site 0523), London

W12 OHS

RECRUITING

Hammersmith Hospital ( Site 0533), London

NE7 7DN

RECRUITING

Freeman Hospital ( Site 0532), Newcastle upon Tyne

NP20 2EF

RECRUITING

Royal Gwent Hospital ( Site 0524), Newport

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY