Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

August 5, 2024

Primary Completion Date

June 30, 2027

Study Completion Date

May 31, 2028

Conditions
Extensive-stage Small-cell Lung CancerSmall-cell Lung Cancer
Interventions
DRUG

BNT327 Dose Level 1 (DL1)

Intravenous (IV) infusion

DRUG

BNT327 Dose Level 2 (DL2)

IV infusion

DRUG

Etoposide

IV infusion

DRUG

Carboplatin

IV infusion

DRUG

Paclitaxel

IV infusion

DRUG

Topotecan

IV infusion or oral capsules

Trial Locations (64)

2065

Royal North Shore Hospital, St Leonards

2145

Westmead Hospital, Westmead

3065

St. Vincent's Hospital, Fitzroy

3199

Peninsula Oncology Centre, Frankston

4522

Adana City Training and Research Hospital, Adana

5112

Lyell McEwin Hospital, Adelaide

10408

National Cancer Center, Goyang-si

11590

Clinical Research Alliance Inc, Westbury

16499

Ajou University Hospital, Suwon

21565

Gachon University Gil Medical Center, Incheon

28374

FirstHealth Outpatient Cancer Center, Pinehurst

28644

Chungbuk National University Hospital, Cheongju-si

32308

Tallahassee Memorial Physician Partners - Cancer & Hematology Specialists, Tallahassee

34010

Koc Universitesi Hastanesi (Koc University Hospital), Istanbul

34093

Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi, Istanbul

34457

Acibadem Adana Hastanesi, Istanbul

34711

Clermont Oncology Center, Clermont

34718

Yeditepe University Kosuyolu Hospital, Istanbul

34722

Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi, Istanbul

34952

Hematology Oncology Associates of Treasure Coast, Port Saint Lucie

35325

Medical Point Izmir Hospital, Izmir

36020

Gaziantep Sanko University Medical Faculty, Gaziantep

37920

University of Tennessee Medical Center, Knoxville

40536

University of Kentucky Chandler Medical Center (UKCMC) - Markey Cancer Center (Lucille P. Markey Cancer Center), Lexington

41380

Kocaeli Universitesi Tip Fakultesi, Kocaeli

42415

Yeungnam University Medical Center, Daegu

45219

The Christ Hospital Cancer Center, Cincinnati

46804

Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne

52727

Gyeongsang National University Hospital (GNUH), Jinju

53715

SSM Health Cancer Care, Madison

54290

Sakarya University - Faculty of Medicine, Sakarya

55407

Allina Health, Minneapolis

59030

Namik Kemal University Hospital, Tekirdağ

61801

Carle Foundation Hospital d/b/a Carle Cancer Center, Urbana

63026

SSM Health Cancer Care - St. Clare, Fenton

68506

Nebraska Hematology-Oncology (NHO) - Lincoln, Lincoln

77090

Millenium Research & Clinical Development, Houston

90067

Valkyrie Clinical Trials, Los Angeles

99508

Alaska Oncology and Hematology, LLC, Anchorage

28721-8046

Haywood Infusion Center, Clyde

02841

Korea University Anam Hospital, Seoul

03722

Severance Hospital, Yonsei University Health System, Seoul

06591

The Catholic University of Korea Seoul St. Mary's Hospital, Seoul

01120

Baskent University Hospital Adana Dr Turgut Noyan Research Center, Adana

01230

Medical Park Seyhan Hospital, Adana

06010

Gulhane Egitim ve Arastirma Hastanesi, Ankara

06170

Ankara Etlik Sehir Hastanesi, Ankara

06200

Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital, Ankara

06230

Hacettepe University Medical Faculty Oncology Hospital, Ankara

06520

Memorial Ankara Hospital, Ankara

06680

Liv Hospital, Ankara

06800

Ankara City Hospital, Ankara

06560

Gazi University Medical Faculty, Yenimahalle

B15 2GW

Queen Elizabeth Hospital Birmingham - University Hospitals Birmingham NHS Foundation Trust, Birmingham

CF14 2TL

Velindre Hospital - Velindre NHS Trust, Cardiff

DD1 9SY

Ninewells Hospital and Medical School - Tayside Health Board, Dundee

EX2 5DW

Royal Devon and Exeter Hospital, Wonford - Royal Devon And Exeter NHS Foundation Trust, Exeter

HD3 3EA

Huddersfield Royal Infirmary - Calderdale and Huddersfield NHS Foundation Trust, Huddersfield

LS9 7TF

St James's University Hospital - Leeds Teaching Hospitals NHS Trust, Leeds

W1G 6AD

Sarah Cannon Research Institute, London

NE7 7DN

Northern Centre for Cancer Care,The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne

NG5 1PB

Nottingham University Hospitals NHS Trust, Nottingham

PR2 9HT

Royal Preston Hospital - Lancashire Teaching Hospitals NHS Foundation Trust, Preston

ST4 6QG

Royal Stoke University Hospital - University Hospitals of North Midlands NHS Trust, Stoke-on-Trent

Sponsors

Lead Sponsor

All Listed Sponsors
lead

BioNTech SE

INDUSTRY