A Study to Learn About the Study Medicine PF-07934040 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Genetic Mutation.

PHASE1RecruitingINTERVENTIONAL
Enrollment

330

Participants

Timeline

Start Date

June 27, 2024

Primary Completion Date

September 10, 2027

Study Completion Date

September 9, 2028

Conditions
Carcinoma, Pancreatic DuctalColorectal NeoplasmsCarcinoma, Non-Small-Cell Lung
Interventions
DRUG

PF-07934040

panKRAS inhibitor

COMBINATION_PRODUCT

Gemcitabine

Chemotherapy (antimetabolite)

COMBINATION_PRODUCT

Nab-paclitaxel

Taxane-type Chemotherapy

COMBINATION_PRODUCT

Cetuximab

Monoclonal Antibody (EGFR Inhibitor)

COMBINATION_PRODUCT

Fluorouracil

"Part of FOLFOX chemotherapy regimen~cytotoxic chemotherapy (antimetabolite and pyrimidine analog)"

COMBINATION_PRODUCT

Oxaliplatin

"Part of FOLFOX Chemotherapy Regimen~platinum based compound (alkylating agent)"

COMBINATION_PRODUCT

Leucovorin

"Part of FOLFOX chemotherapy regimen~Folic Acid Analog"

COMBINATION_PRODUCT

Bevacizumab

VEG-F inhibitor

COMBINATION_PRODUCT

Pembrolizumab

immune checkpoint inhibitor (PD-1 inhibitor)

COMBINATION_PRODUCT

pemetrexed

"Can be used in Platinum-based Chemotherapy regimen~Antimetabolite"

COMBINATION_PRODUCT

Cisplatin

"Can be used as part of Platinum-based chemotherapy regimen~Platinum-based antineoplastic (alkylating agent)"

COMBINATION_PRODUCT

Paclitaxel

"Can be used in Platinum-based chemotherapy regimen~Taxane"

COMBINATION_PRODUCT

Carboplatin

"Can be used as part of a platinum-based chemotherapy regimen~platinum containing compound (alkylating agent)"

Trial Locations (26)

27710

RECRUITING

Duke University Medical Center, lnvestigational Chemotherapy Service, Durham

RECRUITING

Duke University Medical Center, Durham

44195

RECRUITING

Cleveland Clinic Taussig Cancer Center, Cleveland

45069

RECRUITING

West Chester Hospital, West Chester

45219

RECRUITING

University of Cincinnati Medical Center, Cincinnati

49546

RECRUITING

START Midwest, Grand Rapids

63031

RECRUITING

Siteman Cancer Center - North County, Florissant

63108

RECRUITING

Siteman Cancer Center, St Louis

63110

RECRUITING

Barnes-Jewish Hospital, St Louis

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center - South County, St Louis

63141

RECRUITING

Siteman Cancer Center - West County, Creve Coeur

63376

RECRUITING

Siteman Cancer Center - St Peters, City of Saint Peters

72703

RECRUITING

Highlands Oncology Group, PA, Fayetteville

72758

RECRUITING

Highlands Oncology Group, PA, Rogers

72762

RECRUITING

Highlands Oncology Group, Springdale

77030

RECRUITING

University of Texas MD Anderson Cancer Center, Houston

80045

RECRUITING

University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP), Aurora

RECRUITING

University of Colorado Hospital - Anschutz Outpatient Pavilion, Aurora

RECRUITING

University of Colorado Hospital- Anschutz Cancer Pavilion (ACP), Aurora

RECRUITING

University of Colorado Hospital, Aurora

91010

RECRUITING

City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte

RECRUITING

City of Hope Investigational Drug Service (IDS), Duarte

02903

RECRUITING

Rhode Island Hospital, Providence

02906

RECRUITING

Miriam Hospital, Providence

00935

RECRUITING

Pan American Center for Oncology Trials, LLC, Rio Piedras

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY