Effect of Proactive Therapeutic Drug Monitoring on Maintenance of Sustained Disease Control in Adults With Rheumatoid Arthritis on a Subcutaneous TNF Inhibitor: The Rheumatoid Arthritis Therapeutic DRUg Monitoring Trial (RA-DRUM)

PHASE4RecruitingINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

August 20, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Therapeutic drug monitoring (TDM) of adalimumab

"In the TDM-group, the adalimumab dose will be adjusted according to the following algorithms in order to keep the drug level within the therapeutic range:~* Serum drug level within therapeutic range : keep dose~* Low drug levels, ADAb undetectable or low levels : Decrease dosing interval by one week to a maximum of 40 mg/week~* Low drug levels, ADAb high levels : Switch to another therapy~* High drug levels : Increase dosing interval by one week up to a maximum of 6 weeks"

Trial Locations (21)

1535

RECRUITING

Østfold Hospital Trust, Moss

2609

RECRUITING

Lillehammer Hospital for Rheumatic Diseases, Lillehammer

3004

RECRUITING

Drammen Hospital, Drammen

3722

RECRUITING

Betanien Hospital, Skien

4019

RECRUITING

Stavanger University Hospital, Stavanger

4615

RECRUITING

Hospital of Southern Norway Trust, Kristiansand

5009

RECRUITING

Haukeland University Hospital, Bergen

5528

RECRUITING

Haugesund Rheumatism Hospital, Haugesund

6017

RECRUITING

Ålesund Hospital, Ålesund

6812

RECRUITING

Førde Hospital Trust, Førde

7030

RECRUITING

St.Olavs Hospital, Trondheim

8005

RECRUITING

Nordland Hospital Trust, Bodø

8613

RECRUITING

Helgeland Hospital Trust, Mo i Rana

9019

RECRUITING

University Hospital of North Norway, Tromsø

41345

RECRUITING

Sahlgrenska Universitetssjukehuset, Gothenburg

A-1090

RECRUITING

Medical University Vienna, Vienna

0319

RECRUITING

Diakonhjemmet sykehus, Oslo

Unknown

RECRUITING

Martina Hansen's Hospital, Sandvika

RECRUITING

Carol Davila University of Medicine and Pharmacy Bucharest, Bucharest

141 86

RECRUITING

Karolinska University Hospital, Stockholm

SW15 5PN

NOT_YET_RECRUITING

Queen Mary, London

All Listed Sponsors
collaborator

Oslo University Hospital

OTHER

collaborator

Karolinska University Hospital

OTHER

collaborator

Queen Mary University of London

OTHER

collaborator

Medical University of Vienna

OTHER

collaborator

Alesund Hospital

OTHER

collaborator

St. Olavs Hospital

OTHER

collaborator

Helse Stavanger HF

OTHER_GOV

collaborator

Drammen sykehus

OTHER

collaborator

University Hospital of North Norway

OTHER

collaborator

Førde Hospital Trust

OTHER

collaborator

Hospital of Southern Norway Trust

OTHER

collaborator

Haukeland University Hospital

OTHER

collaborator

Ostfold Hospital Trust

OTHER

collaborator

Lillehammer Hospital for Rheumatic Diseases

OTHER

collaborator

Martina Hansen's Hospital

OTHER

collaborator

Haugesund Rheumatism Hospital

OTHER

collaborator

Betanien Hospital

OTHER

collaborator

Helgeland Hospital Trust

OTHER

collaborator

Nordlandssykehuset HF

OTHER

collaborator

Carol Davila University of Medicine and Pharmacy

OTHER

lead

Diakonhjemmet Hospital

OTHER