A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

550

Participants

Timeline

Start Date

August 13, 2024

Primary Completion Date

September 26, 2028

Study Completion Date

November 26, 2031

Conditions
Metastatic HER2-positive Breast Cancer
Interventions
DRUG

Zanidatamab

Administered by intravenous infusion

DRUG

Trastuzumab

Administered by intravenous infusion

DRUG

Eribulin

Administered by intravenous infusion

DRUG

Vinorelbine

Administered by intravenous infusion

DRUG

Gemcitabine

Administered by intravenous infusion

DRUG

Capecitabine

Given orally

Trial Locations (163)

1070

RECRUITING

Institute Jules Bordet, Anderlecht

1090

RECRUITING

Medizinische Universitat Wien, Vienna

2080

RECRUITING

The Kinghorn Cancer Centre, Mount Kuring-Gai

2650

RECRUITING

UZ Antwerpen, Edegem

3128

RECRUITING

Box Hill Hospital, Melbourne

3149

RECRUITING

Peninsula and South Eastern Haematology and Oncology Group, Mount Waverly

4010

RECRUITING

Ordensklinikum Barmherzige Schwestern, Linz

4575

RECRUITING

Sunshine Coast University Private Hospital, Birtinya

4600

RECRUITING

Klinikum Wels-Grieskirchen GmbH - Abteilung für Innere Medizin IV, Wels

5000

RECRUITING

HPS Pharmacies - Adelaide, Adelaide

RECRUITING

CHU UCL Namur - Site Sainte-Elisabeth, Namur

6008

RECRUITING

St John of God Hospital Subiaco, Subiaco

6020

RECRUITING

Medizinische Universitat Innsbruck, Innsbruck

6060

RECRUITING

Grand Hôpital de Charleroi, Gilly

8800

RECRUITING

AZ Delta- Campus Rumbeke, Roeselare

10029

RECRUITING

The Mount Sinai Hospital, New York

11101

RECRUITING

Memorial Sloan Kettering, Long Island City

11528

RECRUITING

Aretaieio Hospital, Athens

13005

RECRUITING

AP HM Hopital de La Timone, Marseille

13009

RECRUITING

Institut Paoli Calmettes, Marseille

13125

RECRUITING

Helios Klinikum Berlin Buch GmbH Klinik für Gynäkologie und Geburtshilfe, Berlin

13605

RECRUITING

Seoul National University Bundang Hospital, Seongnam-si

14000

RECRUITING

Centre François Baclesse, Caen

15006

RECRUITING

Hospital Universitario A Coruña, A Coruña

15125

RECRUITING

Athens Medical Center, Athens

18016

RECRUITING

Hospital Universitario Clinico San Cecilio, Granada

19104

RECRUITING

Abramson Cancer Center of The University of Pennsylvania, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

20007

RECRUITING

Medstar Georgetown University Hospital, Washington D.C.

20010

RECRUITING

Washington Cancer Center, Washington D.C.

20089

RECRUITING

IRCCS Istituto Clinico Humanitas, Rozzano

20132

RECRUITING

Ospedale San Raffaele S.r.l PPDS, Milan

20141

RECRUITING

Istituto Europeo di Oncologia, Milan

20900

RECRUITING

Fondazione IRCCS San Gerardo dei Tintori, Monza

21000

RECRUITING

Centre Georges François Leclerc, Dijon

21565

RECRUITING

Gachon University Gil Medical Center, Namdong-gu

22031

RECRUITING

Virginia Cancer Specialists, Fairfax

23502

RECRUITING

Virginia Oncology Associates, Sentara Health, Norfolk

24014

RECRUITING

Blue Ridge Cancer Care, Roanoke

24127

RECRUITING

Asst Papa Giovanni Xxiii, Bergamo

26504

RECRUITING

University General Hospital of Patras, Pátrai

27100

RECRUITING

Fondazione IRCCS Policlinico San Matteo, Pavia

28007

RECRUITING

Hospital Beata Maria Ana, Madrid

28033

RECRUITING

MD Anderson Cancer Center, Madrid

28040

RECRUITING

Hospital Clinico San Carlos, Madrid

RECRUITING

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

28806

RECRUITING

Messino Cancer Center, Asheville

31059

RECRUITING

Oncopôle Claudius Regaud Pharmacie, Toulouse

32224

RECRUITING

Mayo Clinic Jacksonville - PPDS, Jacksonville

33076

RECRUITING

Institut Bergonie, Bordeaux

33081

RECRUITING

IRCCS Centro di Riferimento Oncologico di Aviano CRO, Aviano

33401

RECRUITING

Florida Cancer Specialists Research East, West Palm Beach

33705

RECRUITING

Florida Cancer Specialists Research North, St. Petersburg

33901

RECRUITING

Florida Cancer Specialists Research South, Fort Myers

34298

RECRUITING

Pharmacie ICM Val d'Aurelle, Montpellier

35128

RECRUITING

Istituto Oncologico Veneto - I.R.C.C.S., Padua

36312

RECRUITING

CHUVI - H.U. Alvaro Cunqueiro, Vigo

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

38320

RECRUITING

Hospital Universitario de Canarias, San Cristóbal de La Laguna

40138

RECRUITING

Azienda Ospedaliero Universitaria Di Bologna Policlinico S Orsola Malpighi Via Massarenti, Bologna

41013

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

41124

RECRUITING

Azienda Ospedaliero Universitaria di Modena, Modena

44263

RECRUITING

Marienhospital Bottrop gGmbH, Dortmund

45226

RECRUITING

Oncology Hematology Care (OHC), Cincinnati

46010

RECRUITING

Hospital Clínico Universitario de Valencia, Valencia

53226

RECRUITING

Froedtert and The Medical College of Wisconsin, Milwaukee

55433

RECRUITING

Minnesota Oncology Hematology, Coon Rapids

55905

RECRUITING

Mayo Clinic - PPDS, Rochester

57001

RECRUITING

European Interbalkan Medical Center, Thessaloniki

59020

RECRUITING

Centre Oscar Lambret, Lille

64111

RECRUITING

Saint Luke's Cancer Institute, Kansas City

67000

RECRUITING

ICANS - Institut de cancérologie Strasbourg Europe, Strasbourg

72000

RECRUITING

Pharmacie Centre de Cancerologie de la Sarthe, Le Mans

75063

RECRUITING

Maryland Oncology Hematology Healing Way - USOR, Irving

RECRUITING

Medical Oncology Hematology Consultants, Irving

RECRUITING

Nexus Health, Irving

RECRUITING

Sansum Clinic 540 W - USOR, Irving

RECRUITING

Texas Oncology Gulf Coast, Irving

RECRUITING

Texas Oncology West, Irving

76104

RECRUITING

Texas Oncology - Fort Worth, Fort Worth

77030

RECRUITING

U.T. MD Anderson Cancer Center, Investigational Pharmacy Services, Houston

77090

WITHDRAWN

Millennium Research and Clinical Development, Houston

80218

RECRUITING

Rocky Mountain Cancer Centers, Denver

81377

RECRUITING

LMU Klinikum - Apotheke, München

85054

RECRUITING

Mayo Clinic Scottsdale - PPDS, Phoenix

85711

WITHDRAWN

Arizona Oncology Tucson - Wilmot, Tucson

85719

RECRUITING

University of Arizona Cancer Center, Tucson

89081

RECRUITING

Universitätsklinikum Ulm, Ulm

90033

RECRUITING

USC-Norris Comprehensive Cancer Center - Investigational Drug Service IDS, Los Angeles

90703

RECRUITING

The Oncology Institute Of Hope And Innovation, Cerritos

91204

RECRUITING

Los Angeles Hematology Oncology Medical Group Glendale, Glendale

94158

RECRUITING

UCSF at Mission Bay MB, San Francisco

94800

RECRUITING

Gustave Roussy, Villejuif

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

330721

RECRUITING

Soon Chun Hyang University Cheonan Hospital, Cheonan-si

80045-2517

RECRUITING

University of Colorado-Cancer Center-PPDS, Aurora

02215-5418

RECRUITING

Dana Farber Cancer Institute, Boston

07601

RECRUITING

Hackensack Meridian Health, Hackensack

08901

RECRUITING

Rutgers Cancer Institute of New Jersey, New Brunswick

10016-4744

RECRUITING

Perlmutter Cancer Center 160 E 34th St, New York

10032-3729

RECRUITING

Columbia University Medical Center 161 Fort Washington, New York

44106-1716

WITHDRAWN

University Hospitals Cleveland Medical Center 11100 Euclid Ave, Cleveland

02903

RECRUITING

Rhode Island Hospital, Providence

91350-200

RECRUITING

Hospital Nossa Senhora Da Conceição, Porto Alegre

18060-105

RECRUITING

IEPE Unimed Sorocaba, Sorocaba

71.635-610

RECRUITING

DASA Hospital Brasilia, Brasília

60336-232

RECRUITING

Centro Regional Integrado de Oncologia, Ceará

88301-220

RECRUITING

Catarina Pesquisa Clinica, Itajaí

90050-170

RECRUITING

Irmandade Da Santa Casa de Misericordia de Porto Alegre, Portalegre

90610-001

RECRUITING

Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul PUCRS, Porto Alegre

52.010-075

RECRUITING

Real Hospital Portugues de Beneficiencia Em Pernambuco, Recife

40.170-070

RECRUITING

Nucleo de Oncologia Da Bahia, Salvador

09541-270

RECRUITING

Ceon Pesquisas Ltda, São Caetano do Sul

01323-030

RECRUITING

Hospital Beneficiencia Portuguesa, São Paulo

04062-001

RECRUITING

Onco Star Sp Oncologia LTDA, São Paulo

H3T 1E2

RECRUITING

Jewish General Hospital, Montreal

K1H 8L6

RECRUITING

The Ottawa Hospital Cancer Centre, Ottawa

G1S 4L8

RECRUITING

CHU de Québec Université Laval Hôpital du Saint Sacrement, Québec

M4N 3M5

RECRUITING

Sunnybrook Research Institute, Toronto

V5Z 4E6

RECRUITING

BC Cancer-Vancouver Center, Vancouver

01307

RECRUITING

Universitätsklinikum Carl Gustav Carus an der TU, Dresden

260-8717

RECRUITING

Chiba Cancer Center, Chiba

104-0045

RECRUITING

National Cancer Center Hospital, Chūōku

541-8567

RECRUITING

Osaka International Cancer Institute, Chūōku

811-1395

RECRUITING

National Hospital Organization Kyushu Cancer Center, Fukuoka

960-1295

RECRUITING

Fukushima Medical University Hospital, Fukushima

350-1298

RECRUITING

Saitama Medical University International Medical Center, Hidaka-shi

259-1193

RECRUITING

Tokai University Hospital, Isesaki-shi

892-0833

RECRUITING

Sagara Hospital, Kagoshima

606-8507

RECRUITING

Kyoto University Hospital, Kyoto

464-8681

RECRUITING

Aichi Cancer Center, Nagoya

467-8602

RECRUITING

Nagoya City University Hospital, Nagoya

700-8558

RECRUITING

Okayama University Hospital, Okayama

540-0006

RECRUITING

National Hospital Organization Osaka National Hospital, Osaka

003-0804

RECRUITING

National Hospital Organization Hokkaido Cancer Center, Sapporo

113-8431

RECRUITING

Juntendo University Hospital, Tokyo

142-8666

RECRUITING

Showa University Hospital, Tokyo

241-8515

RECRUITING

Kanagawa Cancer Center, Yokohama

15-027

RECRUITING

Białostockie Centrum Onkologii im. Marii Skłodowskiej-Curie w Białymstoku, Bialystok

21-500

RECRUITING

Wojewódzki Szpital Specjalistyczny W Białej Podlaskiej, Biała Podlaska

30-727

RECRUITING

Pratia MCM Kraków, Krakow

60-192

RECRUITING

Pratia Poznan, Poznan

60-569

RECRUITING

Uniwersytecki Szpital Kliniczny w Poznaniu, Poznan

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy w Warszawie, Warsaw

03080

RECRUITING

Seoul National University Hospital, Seoul

03722

RECRUITING

Severance Hospital Yonsei University Health System, Seoul

06273

RECRUITING

Gangnam Severance Hospital, Yonsei University Health System, Seoul

06351

RECRUITING

Samsung Medical Center, Seoul

137-701

RECRUITING

The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul

06006

RECRUITING

Hospital Universitario de Badajoz, Badajoz

08035

RECRUITING

Hospital Universitari Vall d Hebron, Barcelona

08036

RECRUITING

Hospital Clinic de Barcelona, Barcelona

08916

RECRUITING

ICO Badalona-H.U. Germans Trias i Pujol, Barcelona

03203

RECRUITING

Hospital General Universitario de Elche, Elche

BA1 3NG

RECRUITING

Royal United Hospital, Bath

G12 0YN

RECRUITING

Beatson West Of Scotland Cancer Centre, Glasgow

LE2 7LX

RECRUITING

Leicester Royal Infirmary, Leicester

SE1 9RT

RECRUITING

Guy's Hospital, London

W6 8RF

RECRUITING

Charring Cross Hospital, London

M20 4BX

RECRUITING

The Christie - PPDS, Manchester

OX3 7LJ

RECRUITING

Churchill Hospital, Oxford

WV10 0QP

RECRUITING

New Cross Hospital, Wolverhampton

Sponsors
All Listed Sponsors
lead

Jazz Pharmaceuticals

INDUSTRY