83
Participants
Start Date
May 31, 2024
Primary Completion Date
December 31, 2025
Study Completion Date
May 31, 2026
Nelarabine injection
Nelarabine is a prodrug of the nucleotide metabolism inhibitor deoxyguanosine analogue 9-β-arabinoguanine (ARA-G). Nelarabine undergoes catalytic transformation by adenosine deaminase (ADA), resulting in the removal of its methoxy group and conversion into ARA-G, Subsequently, ARA-G undergoes sequential monophosphorylation by deoxyguanosine kinase and deoxycytosine nucleoside kinase, yielding the active compound 5'-Guanosine triphosphate (GTP), ARA-GTP. This active compound accumulates within leukemic blast cells and binds to deoxyribonucleic acid (DNA), effectively inhibiting DNA synthesis and ultimately leading to cell death.
The second Hospital of Hebei Medical University, Shijiazhuang
Xingtai People's Hospital, Xingtai
Aerospace Medical Center, Beijing
Beijing Tongren Hospital,CMU, Beijing
The First Hospital Of Jilin University, Changchun
Affiliated cancer hospital of harbin medical university, Harbin
Institute of Hematology & Oncology, Harbin First Hospital, Harbin
Huashan Hospital Fudan University, Shanghai
Children's Hospital of Fudan University, Shanghai
Nanjing childrens Hospital, Nanjing
Jiangsu Provincial People's Hospital, Nanjing
Anhui Provincial Hospital, Hefei
Weihai Municipal Hospital, Weihai
Tianjin Cancer Hospital, Tianjin
Children's Hospital of Zhejiang University School of Medicine, Hangzhou
Children's Hospital of Chongqing Medical University, Chongqing
The Second Affiliated Hospital of Army Military Medical University, Chongqing
Hunan Children's Hospital, Changsha
Tongji Medical College of HUST, Wuhan
Henan Children's Hospital, Zhengzhou
Sun Yat-sen University Cancer Prevention Center, Guangzhou
Cancer Hospital Affiliated to Guangxi Medical University, Nanning
First Affiliated Hospital of Guangxi Medical University, Nanning
Yulin Red Cross Hospital, Yulin
Affiliated Hospital of Zunyi Medical University, Zunyi
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital, Chengdu
The First Affiliated Hospital of Kunming Medical University, Kunming
Shanxi Provincial People's Hospital, Xi’an
The first hospital of Lanzhou University, Lanzhou
First Affiliated Hospital of Xinjiang Medical University, Ürümqi
Lead Sponsor
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
INDUSTRY