Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

63

Participants

Timeline

Start Date

October 30, 2024

Primary Completion Date

January 10, 2028

Study Completion Date

January 25, 2028

Conditions
Ovarian Cancer
Interventions
DRUG

Tuvusertib (M1774)

Tuvusertib will be administered orally.

DRUG

Niraparib

Niraparib will be administered orally. If selected from Part A, Niraparib will be administered orally in combination with Tuvusertib.

DRUG

Lartesertib (M4076)

Lartesertib will be administered orally. If selected from Part A, Lartesertib will be administered orally in combination with Tuvusertib

Trial Locations (84)

10021

Memorial Sloan Kettering Cancer Center, New York

10029

Icahn School of Medicine at Mount Sinai PRIME - Mount Sinai - PRIME, New York

22031

Next Oncology - Virginia, Fairfax

Virginia Cancer Specialists, PC, Fairfax

31904

Centricity Research Cancer Center - DBA CRRI John B. Amos Cancer Center Research, Columbus

48109

University of Michigan Rogel Cancer Center, Ann Arbor

60637

University of Chicago Comprehensive Cancer Center at Silver Cross - Carolyn J. Czerkies Pavilion, Chicago

72205

University of Arkansas for Medical Sciences, Little Rock

94158

University of California San Francisco - UCSF Medical Center, San Francisco

Unknown

Chris O'Brien Lifehouse, Camperdown

St George Private Hospital, Kogarah

Liverpool Hospital - PARENT, Liverpool

Cliniques Universitaires Saint-Luc - STL, Brussels

UZ Leuven, Leuven

Ålborg Universitets Hospital - PARENT, Aalborg

Rigshospitalet, Copenhagen

Sjaellands Universitetshospital - other, Odense

ICO - Site Paul Papin - service d'oncologie medicale, Angers

Centre Francois Baclesse - Service d'Oncologie Medicale, Caen

Centre Oscar Lambret - service de cancerologie gynecologique, Lille

Centre Leon Berard - Service d'Oncologie Medicale, Lyon

Groupe Hospitalier Diaconesses - Hôpital De La Croix Saint Simon - service d'oncologie medicale, Paris

Hopital Tenon - service d'oncologie medicale, Paris

Hôpital Cochin - Hematologie et Oncologie Médicale, Paris

Hôpital Européen Georges Pompidou - Hématologie Oncologie, Paris

Hôpital Saint Joseph - Paris - Service d'Oncologie-Cancerologie, Paris

Centre Hospitalier Lyon Sud - service d'oncologie medicale, Pierre-Bénite

Centre de Radiotherapie Clinique Sainte Anne - 300207251, Strasbourg

Institut de Cancérologie de Strasbourg Europe - ICANS - Service d'oncologie médicale, Strasbourg

Institut Gustave Roussy - Oncologie Médicale, Villejuif

Charité - Campus Virchow-Klinikum - Klinik fuer Gynaekologie, Berlin

Universitaetsklinikum Bonn AoeR - Frauenklinik, Bonn

Universitaetsklinikum Carl Gustav Carus TU Dresden - Klinik u. Poliklinik f. Frauenheilkunde, Dresden

Kliniken Essen-Mitte - Gynaekologie und Gynaekologische Onkologie, Essen

Universitaetsklinikum Leipzig AoeR - Klinik und Poliklinik fuer Frauenheilkunde, Leipzig

Universitaetsklinikum Muenster - Parent, Münster

Universitätsklinikum Münster - Gynecology, Münster

Caritas-Krankenhaus St. Josef - Klinik fuer Chirurgie, Regensburg

Universitaetsklinikum Tuebingen - Parent, Tübingen

Rambam Medical Center, Haifa

The Lady Davis Carmel Medical Center, Haifa

Hadassah University Hospital - Ein Kerem, Jerusalem

Shaare Zedek, Jerusalem

Chaim Sheba Medical Center, Ramat Gan

Azienda Ospedaliera Universitaria Policlinico Sant'Orsola Malpighi IRCCS - Oncologia Medica, Bologna

IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola - SSD Oncologia Medica Zamagni, Bologna

Osp Cannizzaro Catania, Catania

Azienda Ospedaliero-Universitaria Renato Dulbecco - Centro Oncologico, Catanzaro

IEO Istituto Europeo di Oncologia - Unità Ginecologia Oncologica Medica, Milan

Istituto Clinico Humanitas - U.O. di Oncologia Medica ed Ematologia, Milan

Istituto Nazionale Tumori Fondazione G. Pascale - Gynecology, Napoli

IOV - Istituto Oncologico Veneto IRCCS - Radiologia Oncologica, Padua

Istituto Nazionale Tumori Regina Elena IRCCS - UOC Oncologia Medica A, Roma

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - UOC Ostetricia e ginecologia, Rome

Catharina Ziekenhuis Eindhoven - Parent, Eindhoven

Centrum Onkologii im. Prof. F. Lukaszczyka w Bydgoszczy - Dept of Chemotherapy, Bydgoszcz

Szpitale Pomorskie spó, Gdynia

Jagiellonskie Centrum Innowacji Sp. z o.o. - Centrum Bada, Krakow

Instytut MSF Sp.z.o.o, Lodz

Europejskie Centrum Zdrowia - Oddzial Onkologii, Otwock

MICS Centrum Medyczne Torun - Medicovernn, Torun

ICO Badalona - Hospital Universitari Germans Trias i Pujol - Servicio de Oncologia Medica, Badalona

Hospital Clinic de Barcelona - Servicio de Oncologia, Barcelona

Hospital Universitari Vall d'Hebron - Oncology Dept., Barcelona

ICO Girona - Hospital Universitari de Girona Dr Josep Trueta - Servicio de Oncologia Medica, Girona

Clinica Universidad de Navarra (MAD) - Oncology Service, Madrid

Hospital Universitario 12 de Octubre - Servicio de Oncologia, Madrid

Hospital Universitario Ramon y Cajal - Servicio de Oncologia, Madrid

Hospital Regional Universitario de Malaga - Oncology Dept, Málaga

Istituto Oncologico della Svizzera Italiana (IOSI)- Ente Ospedaliero Cantonale (EOC) - Ospedale S.Giovann, Bellinzona

Kantonsspital Frauenfeld - 150509250, Frauenfeld

Kantonsspital Baselland - standort Liestal - Klinik fuer Onkologie, Liestal

Kantonsspital St. Gallen - Klinik fuer Med. Onkologie/Haematologie, Sankt Gallen

Universitaetsspital Zuerich - Klinik fuer Gynaekologie, Zurich

Addenbrooke's Hospital - Dept of Oncology, Cambridge

Beatson West of Scotland Cancer Centre - Dept of Medical Oncology, Glasgow

Royal Surrey County Hospital - Dept of Oncology, Guildford

St James's University Hospital - Dept of Oncology, Leeds

Guy's Hospital - Dept of Medical Oncology, London

Royal Marsden Hospital-London - Dept of Haematology/Oncology Research, London

University College London Hospitals - NIHR/Wellcome Trust, London

The Christie Hospital - Dept of Oncology, Manchester

Mount Vernon Hospital - Dept of Oncology, Northwood

Royal Marsden Hospital-Sutton - Dept of Oncology (Surrey), Sutton

All Listed Sponsors
collaborator

Merck KGaA, Darmstadt, Germany

INDUSTRY

lead

EMD Serono Research & Development Institute, Inc.

INDUSTRY