60
Participants
Start Date
July 1, 2024
Primary Completion Date
March 31, 2030
Study Completion Date
March 31, 2030
MitoQ
MitoQ supplement is composed of mitoquinol mesylate, which is a synthetic analog of coenzyme Q10
Placebo
MitoQ matched Placebo
MitoTempo
During each experimental visit, intradermal microdialysis will be used to locally infuse MitoTempo (a mitochondria-specific superoxide dismutase mimetic) into the cutaneous microvasculature in the ventral aspect of the left forearm.
Tempol
During each experimental visit, intradermal microdialysis will be used to locally infuse Tempol (a superoxide dismutase mimetic) into the cutaneous microvasculature in the ventral aspect of the left forearm.
L-NAME
During each experimental visit, L-NAME (nitric oxide synthase inhibitor) will be perfused through microdialysis fibers for quantification of nitric oxide-mediated vasodilation.
SNP - Sodium Nitroprusside
At the end of each experimental visit, SNP will be perfused through microdialysis fibers to elicit a maximal vasodilation response.
RECRUITING
Ramsey Student Center, University of Georgia, Athens
University of Georgia
OTHER