NCT06423898View on ClinicalTrials.gov

Ampicillin and Ceftriaxone for the Treatment of Enterococcus Faecalis Infective Endocarditis.

PHASE4RecruitingINTERVENTIONAL
Enrollment

284

Participants

Timeline

Start Date

October 9, 2024

Primary Completion Date

July 31, 2027

Study Completion Date

December 31, 2028

Conditions
Endocarditis, Infective
Interventions
DRUG

Ampicillin plus ceftriaxone in continuous infusion

Continuous intravenous antibiotic infusion during 42 days for Infective Endocarditis

DRUG

Ampicillin plus ceftriaxone in intermittent infusion of 14 days, after which the treatment may be changed

"Ampicillin plus ceftriaxone as an intermittent infusion for a minimum of 14 days. After, if the patient is discharged from the hospital, the following treatments, until the 42-day treatment period is completed:~1. Intravenous treatment according to the following regimens:~ Ampicillin plus ceftriaxone as an intermittent infusion, teicoplanin, daptomycin, dalbavancin or linezolid.~2. Oral treatment according to the following regimens: amoxicillin plus moxifloxacin, amoxicillin plus linezolid, amoxicillin plus rifampin, linezolid plus moxifloxacin or linezolid plus rifampin."

Trial Locations (18)

18014

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen de las Nieves, Granada

20014

ACTIVE_NOT_RECRUITING

Hospital Universitario de Donostia, Donostia / San Sebastian

26006

ACTIVE_NOT_RECRUITING

Hospital San Pedro, Logroño

28007

ACTIVE_NOT_RECRUITING

Hospital Universitario Gregorio Marañón, Madrid

28040

NOT_YET_RECRUITING

Hospital Clínico San Carlos, Madrid

28046

NOT_YET_RECRUITING

Hospital Universitario La Paz, Madrid

28222

ACTIVE_NOT_RECRUITING

Hospital Universitario Puerta del Hierro, Madrid

29010

ACTIVE_NOT_RECRUITING

Hospital Universitario Regional de Málaga, Málaga

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen de la Victoria, Málaga

38320

RECRUITING

Hospital Universitario de Canarias, San Cristóbal de La Laguna

39008

RECRUITING

Hospital Universitario Marqués de Valdecilla, Santander

41009

ACTIVE_NOT_RECRUITING

Hospital Universitario Virgen Macarena, Seville

41013

RECRUITING

Hospital Universitario Virgen del Rocío, Seville

48903

ACTIVE_NOT_RECRUITING

Hospital Universitario de Cruces, Barakaldo

01009

RECRUITING

Hospital Universitario de Álava, Alava

08035

NOT_YET_RECRUITING

Hospital Universitario Vall d'Hebron, Barcelona

08036

NOT_YET_RECRUITING

Hospital Clínico de Barcelona, Barcelona

08221

ACTIVE_NOT_RECRUITING

Hospital Universitari MútuaTerrassa, Terrassa

All Listed Sponsors
collaborator

Spanish Clinical Research Network - SCReN

NETWORK

lead

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

OTHER