Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

PHASE3RecruitingINTERVENTIONAL
Enrollment

365

Participants

Timeline

Start Date

September 11, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Metastatic Dedifferentiated LiposarcomaMetastatic Undifferentiated Pleomorphic SarcomaStage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8Unresectable Dedifferentiated LiposarcomaUnresectable Undifferentiated Pleomorphic Sarcoma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Diagnostic Imaging Testing

Undergo standard imaging scans

DRUG

Doxorubicin

Given IV

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA scan

BIOLOGICAL

Pembrolizumab

Given IV

Trial Locations (224)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

11042

RECRUITING

Northwell Health/Center for Advanced Medicine, Lake Success

11553

RECRUITING

Memorial Sloan Kettering Nassau, Uniondale

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15212

RECRUITING

Allegheny General Hospital, Pittsburgh

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

19107

RECRUITING

Pennsylvania Hospital, Philadelphia

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

19713

RECRUITING

Helen F Graham Cancer Center, Newark

RECRUITING

Medical Oncology Hematology Consultants PA, Newark

19967

RECRUITING

Beebe South Coastal Health Campus, Millville

19971

RECRUITING

Beebe Health Campus, Rehoboth Beach

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

27710

RECRUITING

Duke University Medical Center, Durham

29425

RECRUITING

Medical University of South Carolina, Charleston

30308

RECRUITING

Emory University Hospital Midtown, Atlanta

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

33021

RECRUITING

UM Sylvester Comprehensive Cancer Center at Hollywood, Hollywood

33065

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Springs, Coral Springs

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33176

RECRUITING

UM Sylvester Comprehensive Cancer Center at Kendall, Miami

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

40202

RECRUITING

The James Graham Brown Cancer Center at University of Louisville, Louisville

40245

RECRUITING

UofL Health Medical Center Northeast, Louisville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

44011

RECRUITING

UH Seidman Cancer Center at UH Avon Health Center, Avon

44106

RECRUITING

Case Western Reserve University, Cleveland

44122

RECRUITING

UHHS-Chagrin Highlands Medical Center, Beachwood

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

45331

RECRUITING

Miami Valley Cancer Care and Infusion, Greenville

45373

RECRUITING

Upper Valley Medical Center, Troy

45409

RECRUITING

Miami Valley Hospital, Dayton

RECRUITING

Premier Blood and Cancer Center, Dayton

45415

RECRUITING

Miami Valley Hospital North, Dayton

45459

RECRUITING

Miami Valley Hospital South, Centerville

46202

RECRUITING

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis

RECRUITING

Sidney and Lois Eskenazi Hospital, Indianapolis

46307

RECRUITING

UChicago Medicine Northwest Indiana, Crown Point

48038

RECRUITING

Henry Ford Macomb Hospital-Clinton Township, Clinton Township

48109

RECRUITING

University of Michigan Comprehensive Cancer Center, Ann Arbor

48202

RECRUITING

Henry Ford Hospital, Detroit

48322

RECRUITING

Henry Ford West Bloomfield Hospital, West Bloomfield

48377

RECRUITING

Henry Ford Medical Center-Columbus, Novi

49201

RECRUITING

Allegiance Health, Jackson

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50263

RECRUITING

UI Health Care Mission Cancer and Blood - Waukee Clinic, Waukee

50309

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

50314

RECRUITING

Broadlawns Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Laurel Clinic, Des Moines

50325

RECRUITING

UI Health Care Mission Cancer and Blood - West Des Moines Clinic, Clive

50501

RECRUITING

UI Healthcare Mission Cancer and Blood - Fort Dodge, Fort Dodge

51401

RECRUITING

Saint Anthony Regional Hospital, Carroll

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53022

RECRUITING

Aurora Health Care Germantown Health Center, Germantown

53024

RECRUITING

Aurora Cancer Care-Grafton, Grafton

53066

RECRUITING

ProHealth Oconomowoc Memorial Hospital, Oconomowoc

RECRUITING

Aurora Medical Center in Summit, Summit

53081

RECRUITING

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan

53105

RECRUITING

Aurora Cancer Care-Southern Lakes VLCC, Burlington

53110

RECRUITING

Aurora Saint Luke's South Shore, Cudahy

53142

RECRUITING

Aurora Cancer Care-Kenosha South, Kenosha

53149

RECRUITING

ProHealth D N Greenwald Center, Mukwonago

53188

RECRUITING

ProHealth Waukesha Memorial Hospital, Waukesha

RECRUITING

UW Cancer Center at ProHealth Care, Waukesha

53209

RECRUITING

Aurora Cancer Care-Milwaukee, Milwaukee

53215

RECRUITING

Aurora Saint Luke's Medical Center, Milwaukee

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

RECRUITING

Aurora Cancer Care-Milwaukee West, Wauwatosa

53227

RECRUITING

Aurora West Allis Medical Center, West Allis

53233

RECRUITING

Aurora Sinai Medical Center, Milwaukee

53406

RECRUITING

Aurora Cancer Care-Racine, Racine

54143

RECRUITING

Aurora Bay Area Medical Group-Marinette, Marinette

54241

RECRUITING

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers

54311

RECRUITING

Aurora BayCare Medical Center, Green Bay

54806

RECRUITING

Duluth Clinic Ashland, Ashland

54904

RECRUITING

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh

55072

RECRUITING

Essentia Health Sandstone, Sandstone

55746

RECRUITING

Essentia Health Hibbing Clinic, Hibbing

55792

RECRUITING

Essentia Health Virginia Clinic, Virginia

55805

RECRUITING

Essentia Health Cancer Center, Duluth

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

56601

RECRUITING

Sanford Joe Lueken Cancer Center, Bemidji

56636

RECRUITING

Essentia Health - Deer River Clinic, Deer River

57104

ACTIVE_NOT_RECRUITING

Sanford Cancer Center Oncology Clinic, Sioux Falls

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

RECRUITING

Sanford Roger Maris Cancer Center, Fargo

58501

RECRUITING

Sanford Bismarck Medical Center, Bismarck

59101

RECRUITING

Billings Clinic Cancer Center, Billings

59405

RECRUITING

Benefis Sletten Cancer Institute, Great Falls

59711

RECRUITING

Community Hospital of Anaconda, Anaconda

59715

RECRUITING

Bozeman Health Deaconess Hospital, Bozeman

59804

RECRUITING

Community Medical Center, Missoula

59901

RECRUITING

Logan Health Medical Center, Kalispell

60010

RECRUITING

Advocate Good Shepherd Hospital, Barrington

60014

RECRUITING

AMG Crystal Lake - Oncology, Crystal Lake

60026

RECRUITING

Northwestern Medicine Glenview Outpatient Center, Glenview

60030

RECRUITING

Northwestern Medicine Grayslake Outpatient Center, Grayslake

60045

RECRUITING

Northwestern Medicine Lake Forest Hospital, Lake Forest

60048

RECRUITING

AMG Libertyville - Oncology, Libertyville

RECRUITING

Condell Memorial Hospital, Libertyville

60068

RECRUITING

Advocate Lutheran General Hospital, Park Ridge

60115

RECRUITING

Northwestern Medicine Cancer Center Kishwaukee, DeKalb

60123

RECRUITING

Advocate Sherman Hospital, Elgin

60126

RECRUITING

Elmhurst Memorial Hospital, Elmhurst

60134

RECRUITING

Northwestern Medicine Cancer Center Delnor, Geneva

60426

RECRUITING

Ingalls Memorial Hospital, Harvey

60429

RECRUITING

Advocate South Suburban Hospital, Hazel Crest

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

Northwestern Medicine Orland Park, Orland Park

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60506

RECRUITING

Advocate Outpatient Center - Aurora, Aurora

60515

RECRUITING

Advocate Good Samaritan Hospital, Downers Grove

60540

RECRUITING

Edward Hospital/Cancer Center, Naperville

60555

RECRUITING

Northwestern Medicine Cancer Center Warrenville, Warrenville

60585

RECRUITING

Edward Hospital/Cancer Center?Plainfield, Plainfield

60611

RECRUITING

Northwestern University, Chicago

60612

RECRUITING

University of Illinois, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

60657

RECRUITING

Advocate Illinois Masonic Medical Center, Chicago

61021

RECRUITING

Illinois CancerCare-Dixon, Dixon

61350

RECRUITING

Illinois CancerCare-Ottawa Clinic, Ottawa

61354

RECRUITING

Illinois CancerCare-Peru, Peru

61356

RECRUITING

Illinois CancerCare-Princeton, Princeton

61401

RECRUITING

Illinois CancerCare-Galesburg, Galesburg

61443

RECRUITING

Illinois CancerCare-Kewanee Clinic, Kewanee

61455

RECRUITING

Illinois CancerCare-Macomb, Macomb

61520

RECRUITING

Illinois CancerCare-Canton, Canton

61530

RECRUITING

Illinois CancerCare-Eureka, Eureka

61554

RECRUITING

Illinois CancerCare-Pekin, Pekin

61571

RECRUITING

Illinois CancerCare - Washington, Washington

61615

RECRUITING

Illinois CancerCare-Peoria, Peoria

61704

RECRUITING

Illinois CancerCare-Bloomington, Bloomington

61801

RECRUITING

Carle Cancer Center, Urbana

61832

RECRUITING

Carle at The Riverfront, Danville

61938

RECRUITING

Carle Physician Group-Mattoon/Charleston, Mattoon

62269

RECRUITING

Cancer Care Center of O'Fallon, O'Fallon

62321

RECRUITING

Illinois CancerCare-Carthage, Carthage

62401

RECRUITING

Carle Physician Group-Effingham, Effingham

RECRUITING

Crossroads Cancer Center, Effingham

62526

RECRUITING

Cancer Care Specialists of Illinois - Decatur, Decatur

RECRUITING

Decatur Memorial Hospital, Decatur

62702

RECRUITING

Southern Illinois University School of Medicine, Springfield

RECRUITING

Springfield Clinic, Springfield

62781

RECRUITING

Springfield Memorial Hospital, Springfield

62801

RECRUITING

Centralia Oncology Clinic, Centralia

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

68118

RECRUITING

Nebraska Medicine-Village Pointe, Omaha

68123

RECRUITING

Nebraska Medicine-Bellevue, Bellevue

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70809

RECRUITING

Louisiana Hematology Oncology Associates LLC, Baton Rouge

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

80045

RECRUITING

UCHealth University of Colorado Hospital, Aurora

80524

RECRUITING

Poudre Valley Hospital, Fort Collins

80528

RECRUITING

Cancer Care and Hematology-Fort Collins, Fort Collins

80538

RECRUITING

Medical Center of the Rockies, Loveland

80631

RECRUITING

UCHealth Greeley Hospital, Greeley

83605

SUSPENDED

Saint Alphonsus Cancer Care Center-Caldwell, Caldwell

83687

SUSPENDED

Saint Alphonsus Cancer Care Center-Nampa, Nampa

83706

SUSPENDED

Saint Alphonsus Cancer Care Center-Boise, Boise

83814

RECRUITING

Kootenai Health - Coeur d'Alene, Coeur d'Alene

83854

RECRUITING

Kootenai Clinic Cancer Services - Post Falls, Post Falls

83864

RECRUITING

Kootenai Clinic Cancer Services - Sandpoint, Sandpoint

85054

RECRUITING

Mayo Clinic Hospital in Arizona, Phoenix

85719

RECRUITING

Banner University Medical Center - Tucson, Tucson

RECRUITING

University of Arizona Cancer Center-North Campus, Tucson

87106

RECRUITING

University of New Mexico Cancer Center, Albuquerque

90020

RECRUITING

Keck Medicine of USC Koreatown, Los Angeles

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

92663

RECRUITING

USC Norris Oncology/Hematology-Newport Beach, Newport Beach

93720

RECRUITING

Kaiser Permanente Fresno Orchard Plaza, Fresno

RECRUITING

Kaiser Permanente-Fresno, Fresno

94080

RECRUITING

Kaiser Permanente-South San Francisco, South San Francisco

94115

RECRUITING

Kaiser Permanente-San Francisco, San Francisco

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94304

RECRUITING

Stanford Cancer Institute Palo Alto, Palo Alto

RECRUITING

VA Palo Alto Health Care System, Palo Alto

94538

RECRUITING

Kaiser Permanente-Fremont, Fremont

94568

RECRUITING

Kaiser Permanente Dublin, Dublin

94577

RECRUITING

Kaiser Permanente San Leandro, San Leandro

94589

RECRUITING

Kaiser Permanente-Vallejo, Vallejo

94596

RECRUITING

Kaiser Permanente-Walnut Creek, Walnut Creek

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

94903

RECRUITING

Kaiser San Rafael-Gallinas, San Rafael

95051

RECRUITING

Kaiser Permanente Medical Center - Santa Clara, Santa Clara

95119

RECRUITING

Kaiser Permanente-Santa Teresa-San Jose, San Jose

95356

RECRUITING

Kaiser Permanente-Modesto, Modesto

95403

RECRUITING

Kaiser Permanente-Santa Rosa, Santa Rosa

95661

RECRUITING

Kaiser Permanente-Roseville, Roseville

95814

RECRUITING

Kaiser Permanente Downtown Commons, Sacramento

95823

RECRUITING

Kaiser Permanente-South Sacramento, Sacramento

96819

RECRUITING

Kaiser Permanente Moanalua Medical Center, Honolulu

97239

RECRUITING

Oregon Health and Science University, Portland

97914

SUSPENDED

Saint Alphonsus Cancer Care Center-Ontario, Ontario

06418

RECRUITING

Smilow Cancer Hospital-Derby Care Center, Derby

06824

RECRUITING

Smilow Cancer Hospital Care Center-Fairfield, Fairfield

06830

RECRUITING

Smilow Cancer Hospital Care Center at Greenwich, Greenwich

06437

RECRUITING

Smilow Cancer Hospital Care Center - Guilford, Guilford

06520

RECRUITING

Yale University, New Haven

06902

RECRUITING

Smilow Cancer Hospital Care Center at Long Ridge, Stamford

06790

RECRUITING

Smilow Cancer Hospital-Torrington Care Center, Torrington

06611

RECRUITING

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

06708

RECRUITING

Smilow Cancer Hospital-Waterbury Care Center, Waterbury

06385

RECRUITING

Smilow Cancer Hospital Care Center - Waterford, Waterford

32224-9980

RECRUITING

Mayo Clinic in Florida, Jacksonville

60453-2699

RECRUITING

Advocate Christ Medical Center, Oak Lawn

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07920

RECRUITING

Memorial Sloan Kettering Basking Ridge, Basking Ridge

45005-1066

RECRUITING

Atrium Medical Center-Middletown Regional Hospital, Franklin

57117-5134

ACTIVE_NOT_RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

T6G 1Z2

RECRUITING

Cross Cancer Institute, Edmonton

R3E 0V9

RECRUITING

CancerCare Manitoba, Winnipeg

L8V 5C2

RECRUITING

Juravinski Cancer Centre at Hamilton Health Sciences, Hamilton

K1H 8L6

RECRUITING

Ottawa Hospital and Cancer Center-General Campus, Ottawa

M5G 2M9

RECRUITING

University Health Network-Princess Margaret Hospital, Toronto

00902

RECRUITING

Pan American Center for Oncology Trials LLC, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH