Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

PHASE3RecruitingINTERVENTIONAL
Enrollment

851

Participants

Timeline

Start Date

June 10, 2024

Primary Completion Date

January 12, 2029

Study Completion Date

February 12, 2031

Conditions
Non-small Cell Lung CancerNSCLC
Interventions
BIOLOGICAL

Pembrolizumab

Intravenous (IV) infusion

BIOLOGICAL

sac-TMT

IV infusion

DRUG

Carboplatin

Participants receive AUC 6 mg/mL/min IV infusion on Day 1 of each 21-day cycle for 4 cycles as background therapy during the study.

DRUG

Paclitaxel

Participants receive 200 mg/m\^2 IV infusion on Day 1 of each 21-day cycle for 4 cycles as background therapy during the study.

DRUG

Nab-paclitaxel

Participants receive 100 mg/m\^2 IV infusion on Days 1, 8 and 15 of each 21-day cycle for 4 cycles as background therapy during the study.

Trial Locations (199)

106

RECRUITING

National Taiwan University Cancer Center (NTUCC) ( Site 2209), Taipei City

333

RECRUITING

Chang Gung Medical Foundation-Linkou Branch-Clinic of Chest Medicine ( Site 2202), Taoyuan District

407

RECRUITING

Taichung Veterans General Hospital ( Site 2204), Taichung

704

RECRUITING

National Cheng Kung University Hospital ( Site 2205), Tainan City

1121

RECRUITING

Országos Korányi Pulmonológiai Intézet ( Site 1104), Budapest

1130

RECRUITING

Klinik Hietzing ( Site 0740), Vienna

1140

RECRUITING

Standort Penzing der Klinik Ottakring-Abteilung für Atemwegs-und Lungenkrankheiten ( Site 0730), Vienna

1210

RECRUITING

Klinik Floridsdorf-Abteilung für Innere Medizin und Pneumologie ( Site 0710), Vienna

2045

RECRUITING

Reformatus Pulmonologiai Centrum ( Site 1102), Törökbálint

4020

RECRUITING

Ordensklinikum Linz GmbH Elisabethinen-Department of Pneumology ( Site 0720), Linz

5004

RECRUITING

Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház-Onkologiai Kozpont ( Site 1103), Szolnok

6000

RECRUITING

Bacs-Kiskun Varmegyei Oktatokorhaz ( Site 1100), Kecskemét

8900

RECRUITING

Zala Megyei Szent Rafael Kórház ( Site 1110), Zalaegerszeg

9024

RECRUITING

Petz Aladar Egyetemi Oktato Korhaz ( Site 1101), Győr

10002

RECRUITING

National Taiwan University Hospital-Oncology ( Site 2208), Taipei

10300

RECRUITING

Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 2300), Dusit

10449

RECRUITING

Mackay Memorial Hospital-Chest Medicine ( Site 2201), Taipei

10700

RECRUITING

Faculty of Medicine Siriraj Hospital ( Site 2301), Bangkok

13008

RECRUITING

Clínica San Antonio ( Site 0606), Trujillo

13009

RECRUITING

Clinique Clairval ( Site 0904), Marseille

13353

RECRUITING

Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 1003), Berlin

14001

RECRUITING

Clínicas AUNA Sede Chiclayo ( Site 0604), Chiclayo

15036

RECRUITING

Oncosalud-Clinical Research ( Site 0600), Lima

15076

RECRUITING

Hospital Militar Central Coronel Luis Arias Schereiber ( Site 0602), Lima

15706

RECRUITING

CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 1703), Santiago de Compostela

16132

RECRUITING

Ospedale San Martino ( Site 1407), Genova

18015

RECRUITING

St Luke's University Health Network ( Site 0017), Bethlehem

19107

RECRUITING

Thomas Jefferson University - Clinical Research Institute ( Site 0147), Philadelphia

20089

RECRUITING

Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1408), Rozzano

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1404), Milan

20900

RECRUITING

Fondazione IRCCS San Gerardo dei Tintori-Oncologia ( Site 1412), Monza

21100

RECRUITING

Ospedale di Circolo e Fondazione Macchi Varese-Oncology ( Site 1413), Varese

21431

RECRUITING

The Catholic University of Korea, Incheon St. Mary's Hospital ( Site 2106), Bupyeong-gu

22000

RECRUITING

Prapokklao Hospital ( Site 2306), Mueang

23538

RECRUITING

Universitätsklinikum Schleswig-Holstein-Pneumologie ( Site 1000), Lübeck

25123

RECRUITING

Azienda Ospedaliera Spedali Civili di Brescia-Oncology ( Site 1414), Brescia

27100

RECRUITING

Fondazione IRCCS Policlinico San Matteo-Oncology ( Site 1410), Pavia

28040

RECRUITING

Hospital Universitario Fundación Jiménez Díaz-Oncology & Hematology ( Site 1702), Madrid

29004

RECRUITING

Hospital Quirón Málaga ( Site 1704), Málaga

30060

COMPLETED

Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital ( Site 0001), Marietta

30265

RECRUITING

Southeastern Regional Medical Center ( Site 0004), Newnan

31904

COMPLETED

Centricity Research Columbus Cancer Center ( Site 0111), Columbus

32763

COMPLETED

Mid Florida Hematology and Oncology Center ( Site 0109), Orange City

33004

RECRUITING

Taoyuan General Hospital ( Site 2203), Taoyuan

33240

RECRUITING

Mersin Sehir Eğitim ve Araştırma Hastanesi-Oncology ( Site 1808), Mersin

34214

RECRUITING

Medipol Mega Universite Hastanesi-oncology ( Site 1811), Stanbul

35015

RECRUITING

Chungnam national university hospital-Department of Internal Medicine ( Site 2107), Daejeon

35016

RECRUITING

Hospital Insular de Gran Canaria-Oncology ( Site 1701), Las Palmas de Gran Canaria

35360

RECRUITING

Izmir Atatürk Training and Research Hospital ( Site 1810), Izmir

38010

RECRUITING

Memorial Kayseri Hastanesi ( Site 1805), Kayseri

40002

RECRUITING

Faculty of Medicine - Khon Kaen University ( Site 2305), Muang

41014

RECRUITING

Hospital Universitario Virgen de Valme-Departamento de Oncologia ( Site 1705), Seville

41404

RECRUITING

Kyungpook National University Chilgok Hospital-Pulmonology ( Site 2102), Deagu

44309

RECRUITING

GEFOS Gesellschaft f. onkologische Studien ( Site 1005), Dortmund

45136

RECRUITING

Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung ( Site 1001), Essen

49055

RECRUITING

Institut de Cancérologie de l'Ouest ( Site 0908), Angers

49241

RECRUITING

Pusan National University Hospital ( Site 2100), Busan

50200

RECRUITING

Maharaj Nakorn Chiang Mai Hospital ( Site 2302), Chiang Mai

50612

RECRUITING

Pusan National University Yangsan Hospital ( Site 2104), Yangsan

52000

RECRUITING

Lampang Cancer Hospital ( Site 2304), Lampang

55200

RECRUITING

Samsun Medical Park Hastanesi-medical oncology ( Site 1806), Samsun

55407

RECRUITING

Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0146), Minneapolis

57070

RECRUITING

Hôpital Robert Schuman ( Site 0907), Vantoux

60637

RECRUITING

University of Chicago Medical Center ( Site 0145), Chicago

72205

RECRUITING

CARTI Cancer Center ( Site 0006), Little Rock

75475

RECRUITING

Hôpital Saint-Louis ( Site 0906), Paris

77030

RECRUITING

Oncology Consultants P.A. ( Site 0124), Houston

78229

RECRUITING

Mays Cancer Center ( Site 0132), San Antonio

80131

RECRUITING

Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia clinica sperimentale Toraco-Polmonare ( Site 1401), Napoli

80401

RECRUITING

Exempla Lutheran Medical Center ( Site 0119), Golden

81501

RECRUITING

Intermountain Health St. Mary's Regional Hospital ( Site 0116), Grand Junction

83301

RECRUITING

Chang Gung Memorial Hospital at Kaohsiung ( Site 2207), Kaohsiung City

84000

RECRUITING

Sainte Catherine Institut du Cancer Avignon Provence ( Site 0902), Avignon

85000

RECRUITING

CHD Vendee ( Site 0901), La Roche-sur-Yon

87109

COMPLETED

New Mexico Oncology Hematology Consultants Ltd. ( Site 0123), Albuquerque

87131

RECRUITING

University of New Mexico Comprehensive Cancer Center ( Site 0135), Albuquerque

90110

RECRUITING

Songklanagarind hospital ( Site 2303), Hat Yai

91505

RECRUITING

Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center ( Site 0122), Burbank

92510

RECRUITING

Burjeel Medical City ( Site 2600), Abu Dhabi

100142

RECRUITING

Beijing Cancer Hospital ( Site 2411), Beijing

RECRUITING

Beijing Cancer hospital-intrathoratic deparmtment II ( Site 2410), Beijing

100730

RECRUITING

Peking Union Medical College Hospital ( Site 2412), Beijing

110131

RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0500), Bogotá

130000

RECRUITING

Jilin Province Tumor Hospital-GCP office ( Site 2413), Changchun

130021

RECRUITING

The First Hospital of Jilin University-Oncology ( Site 2414), Changchun

150000

RECRUITING

Harbin Medical University Cancer Hospital-oncology of department ( Site 2415), Harbin

200001

RECRUITING

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0501), Valledupar

200120

RECRUITING

Shanghai East Hospital ( Site 2428), Shanghai

200433

RECRUITING

Shanghai Pulmonary Hospital ( Site 2427), Shanghai

200542

RECRUITING

Centrul de Oncologie Sfantul Nectarie-Medical ( Site 2004), Craiova

223300

RECRUITING

First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 2402), Huai'an

225001

RECRUITING

Northern Jiangsu People's Hospital-General Surgery Department ( Site 2403), Yangzhou

300239

RECRUITING

Cabinet Medical Oncomed ( Site 2005), Timișoara

310000

RECRUITING

The first Affiliated Hospital, Zhejiang University School of Medicine-Respiratory Department ( Site 2406), Hangzhou

310016

RECRUITING

Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-Medical Oncology ( Site 2407), Hangzhou

310022

RECRUITING

Zhejiang Cancer Hospital-Breast Oncology ( Site 2408), Hangzhou

317000

RECRUITING

Taizhou Hospital of Zhejiang Province ( Site 2430), Taizhou

325015

RECRUITING

The First Affiliated Hospital of Wenzhou Medical University-Respiratory department ( Site 2409), Wenzhou

330006

RECRUITING

The Second Affiliated Hospital of Nanchang University-Oncology Department ( Site 2405), Nanchang

330209

RECRUITING

The First affiliated hospital of Nanchang University (Xianghu campus) ( Site 2404), Nanchang

350014

RECRUITING

Fujian Provincial Cancer Hospital ( Site 2419), Fuzhou

361003

RECRUITING

The First Affiliated hospital of Xiamen University-oncology ( Site 2420), Xiamen

400015

RECRUITING

Cardiomed SRL Cluj-Napoca ( Site 2002), Cluj-Napoca

400042

RECRUITING

Army Medical Center of People's Liberation Army-respiratory ( Site 2426), Chongqing

407280

RECRUITING

SC Radiotherapy Center Cluj SRL-Oncologie Medicala ( Site 2001), Florești

410011

RECRUITING

The Second Xiangya Hospital of Central South University-Oncology ( Site 2418), Changsha

430000

ACTIVE_NOT_RECRUITING

Tongji Hospital Tongji Medical,Science & Technology ( Site 2424), Wuhan

450008

RECRUITING

Henan Cancer Hospital-Pneumology department ( Site 2423), Zhengzhou

500052

RECRUITING

SC ONCO CARD SRL ( Site 2007), Brasov

510160

RECRUITING

The First Affiliated Hospital of Guangzhou Medical University ( Site 2417), Guangzhou

510515

RECRUITING

Southern Medical University Nanfang Hospital-Depatrment of Respiratory and Critical Care Medicine ( Site 2416), Guangzhou

550253

RECRUITING

Clinica Polisano ( Site 2008), Sibiu

610041

RECRUITING

West China Hospital, Sichuan University ( Site 2422), Chengdu

610042

RECRUITING

Sichuan Cancer hospital. ( Site 2421), Chengdu

660001

RECRUITING

Oncologos del Occidente ( Site 0504), Pereira

760032

RECRUITING

Fundación Valle del Lili-Oncology CIC ( Site 0505), Santiago de Cali

830000

RECRUITING

The Affiliated Cancer Hospital of Xinjiang Medical University ( Site 2425), Ürümqi

1240000

RECRUITING

Bradford Hill Norte ( Site 0420), Antofagasta

2520598

RECRUITING

ONCOCENTRO APYS-ACEREY ( Site 0400), Viña del Mar

3109601

RECRUITING

Rambam Health Care Campus-Oncology Division ( Site 1302), Haifa

3481349

RECRUITING

Centro de Investigación del Maule ( Site 0419), Talca

4941492

RECRUITING

Rabin Medical Center ( Site 1303), Petah Tikva

5265601

RECRUITING

Sheba Medical Center ( Site 1301), Ramat Gan

7500921

RECRUITING

FALP ( Site 0409), Santiago

8330024

RECRUITING

Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0402), Santiago

8420383

RECRUITING

Bradfordhill-Clinical Area ( Site 0407), Santiago

9103102

RECRUITING

Shaare Zedek Medical Center ( Site 1300), Jerusalem

C1426ANZ

RECRUITING

Instituto Alexander Fleming ( Site 0203), Ciudad Autónoma de Buenos Aires

B7600FZO

RECRUITING

Instituto de Investigaciones Clínicas Mar del Plata ( Site 0200), Mar del Plata

X5800AEV

RECRUITING

Instituto Médico Río Cuarto ( Site 0204), Río Cuarto

R8402APU

RECRUITING

Fundacion Intecnus ( Site 0205), Bariloche

S2000DVC

RECRUITING

Sanatorio Parque ( Site 0201), Rosario

C1118AAT

RECRUITING

Hospital Aleman-Oncology ( Site 0202), Buenos Aires

50040-000

RECRUITING

Hospital do Cancer de Pernambuco ( Site 0312), Recife

64049-200

RECRUITING

Vencer Centro de Pesquisa Clínica ( Site 0309), Teresina

90020-090

RECRUITING

Irmandade da Santa Casa de Misericórdia de Porto Alegre ( Site 0311), Porto Alegre

91350-200

RECRUITING

Hospital Nossa Senhora da Conceição ( Site 0300), Porto Alegre

96830-180

RECRUITING

Instituto de Oncologia Saint Gallen ( Site 0304), Santa Cruz do Sul

15090-000

RECRUITING

Hospital de Base de São José do Rio Preto ( Site 0310), São José do Rio Preto

01321-001

RECRUITING

Hospital Paulistano ( Site 0307), São Paulo

K7L 2V7

RECRUITING

Kingston Health Sciences Centre-Kingston General Hospital Site ( Site 0100), Kingston

N2G 1G3

RECRUITING

Waterloo Regional Health Network (WRHN) ( Site 0153), Kitchener

H3T 1M5

RECRUITING

St. Marys Hospital Center ( Site 0105), Montreal

H4A 3J1

RECRUITING

McGill University Health Centre ( Site 0103), Montreal

G8Z 3R9

RECRUITING

Centre integre universitaire de sante et de services sociaux de la Mauricie-et-du-centre-du-quebec ( Site 0106), Trois-Rivières

080001

RECRUITING

Centro Cancerológico del Caribe (CECAC) ( Site 0509), Barranquilla

656 53

RECRUITING

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0800), Brno

703 00

RECRUITING

Nemocnice AGEL Ostrava - Vitkovice a.s.-Plicni oddeleni ( Site 0803), Ostrava-Vitkovice

532 03

RECRUITING

Multiscan-Onkologicke a radiologicke centrum Multiscan Pardubice ( Site 0804), Pardubice

779 00

RECRUITING

Fakultni nemocnice Olomouc-Klinika plicnich nemoci a tuberkulozy ( Site 0802), Olomouc

07548

RECRUITING

SRH Wald-Klinikum Gera-Zentrum für klinische Studien ( Site 1006), Gera

D08 A978

RECRUITING

St. James's Hospital ( Site 1200), Dublin

00184

RECRUITING

Azienda Ospedaliera S. Giovanni Addolorata-Oncologia Medica ( Site 1409), Rome

00144

RECRUITING

Istituto Nazionale Tumori Regina Elena-Oncologia Medica 2 ( Site 1402), Rome

464-8681

RECRUITING

Aichi Cancer Center ( Site 2502), Nagoya

466-8560

RECRUITING

Nagoya University Hospital ( Site 2519), Nagoya

470-1192

RECRUITING

Fujita Health University Hospital ( Site 2515), Toyoake

036-8563

RECRUITING

Hirosaki University Hospital ( Site 2514), Hirosaki

277-8577

RECRUITING

National Cancer Center Hospital East ( Site 2501), Kashiwa

791-0295

RECRUITING

Ehime University Hospital ( Site 2511), Tōon

373-8550

RECRUITING

Gunma Prefectural Cancer Center ( Site 2510), Ōta

665-0827

RECRUITING

Takarazuka City Hospital ( Site 2508), Takarazuka

920-8641

RECRUITING

Kanazawa University Hospital ( Site 2513), Kanazawa

216-8511

RECRUITING

St. Marianna University Hospital ( Site 2521), Kawasaki

236-0051

RECRUITING

Kanagawa Cardiovascular and Respiratory Center ( Site 2518), Yokohama

241-8515

RECRUITING

Kanagawa Cancer Center ( Site 2504), Yokohama

515-8544

RECRUITING

Matsusaka Municipal Hospital ( Site 2522), Matsusaka

981-0914

RECRUITING

Sendai Kousei Hospital ( Site 2507), Sendai

573-1191

RECRUITING

Kansai Medical University Hospital ( Site 2503), Hirakata

362-0806

RECRUITING

Saitama Prefectural Cancer Center ( Site 2512), Kitaadachi-gun

135-8550

RECRUITING

Cancer Institute Hospital of JFCR ( Site 2500), Koto

143-8541

RECRUITING

Toho University Omori Medical Center ( Site 2520), Ōta-ku

162-8655

RECRUITING

National Center for Global Health and Medicine ( Site 2516), Shinjuku

755-0241

RECRUITING

National Hospital Organization Yamaguchi Ube Medical Center ( Site 2523), Ube

260-8677

RECRUITING

Chiba University Hospital ( Site 2517), Chiba

810-8563

RECRUITING

National Hospital Organization Kyushu Medical Center ( Site 2509), Fukuoka

951-8566

RECRUITING

Niigata Cancer Center Hospital ( Site 2505), Niigata

541-8567

RECRUITING

Osaka International Cancer Institute ( Site 2506), Osaka

85-796

RECRUITING

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1503), Bydgoszcz

86-300

RECRUITING

Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1513), Grudziądz

38-300

RECRUITING

Szpital Specjalistyczny im. Henryka Klimontowicza ( Site 1507), Gorlice

31-826

RECRUITING

Szpital Specjalistyczny im. Ludwika Rydygiera w Krakowie-Oncology Department ( Site 1515), Krakow

60-569

RECRUITING

Wielkopolskie Centrum Pulmonologii i Torakochirurgii-Oddzial Onkologii Klinicznej z Pododdzialem Dz ( Site 1510), Poznań

01-138

RECRUITING

Instytut Gruźlicy i Chorób Płuc w Warszawie ( Site 1523), Warsaw

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 1500), Warsaw

37-700

RECRUITING

Wojewodzki Szpital im. Sw. Ojca Pio w Przemyslu ( Site 1501), Przemyśl

75-581

RECRUITING

Szpital Wojewódzki w Koszalinie. ( Site 1517), Poland

010626

RECRUITING

Centrul Medical Medicover Victoria ( Site 2000), Bucharest

012292

RECRUITING

Lotus-Med ( Site 2009), Bucharest

02447

RECRUITING

Kyung Hee University Hospital ( Site 2101), Seoul

05505

RECRUITING

Asan Medical Center ( Site 2105), Seoul

08308

RECRUITING

Korea University Guro Hospital-Internal Medicine ( Site 2103), Seoul

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1700), Barcelona

06230

RECRUITING

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1801), Ankara

06560

RECRUITING

Gazi Universitesi-Oncology ( Site 1804), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1800), Ankara

TQ2 7AA

RECRUITING

Torbay Hospital ( Site 1906), Torquay

EC1A7BE

RECRUITING

St Bartholomew's Hospital ( Site 1901), London

NG5 1PB

RECRUITING

City Hospital, Nottingham University Hospitals NHS Trust-NCCTT ( Site 1911), Nottingham

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INDUSTRY