A Study to Test the Safety, Tolerability, and Efficacy of an Antibody, REGN7999, Injected Under the Skin for the Treatment of Iron Overload in Adult Participants With Non-Transfusion Dependent β-thalassemia, Using MRI Scans to Measure Iron Levels in the Body

PHASE2RecruitingINTERVENTIONAL
Enrollment

95

Participants

Timeline

Start Date

September 30, 2024

Primary Completion Date

January 24, 2028

Study Completion Date

January 24, 2028

Conditions
Non-Transfusion Dependent Beta-Thalassemia (NTDT)
Interventions
DRUG

REGN7999

Administered subcutaneous (SC)

DRUG

Placebo

Administered SC

Trial Locations (22)

10065

RECRUITING

Weill Cornell Medicine, New York

10330

RECRUITING

Chulalongkorn University, Bangkok

10400

RECRUITING

Phramongkutklao Hospital, Bangkok

40000

RECRUITING

Srinagarind Hospital, Khon Kaen

44124

RECRUITING

Day Hospital Thalassemia and Haemoglobinopathies (DHTE); A.O.U S.Anna, Ferrara

50200

RECRUITING

Chiang Mai University, Chiang Mai

56000

RECRUITING

Hospital Tunku Ampuan Besar Tuanku Aishah Rohani (HPKK UKM), Kuala Lumpur

68000

RECRUITING

Hospital Ampang, Ampang

88586

RECRUITING

Hospital Queen Elizabeth, Kota Kinabalu

90110

RECRUITING

Songklanagarind Hospital, Prince of Songkla University, Hat Yai

93586

RECRUITING

Sarawak General Hospital, Kuching

110029

RECRUITING

All India Institute of Medical Sciences, New Delhi, New Delhi

110048

RECRUITING

Indraprastha Apollo Hospitals, Delhi

302004

RECRUITING

JK Lon Hospital, Jaipur

380009

RECRUITING

Hemato-Oncology Clinic Ahmedabad PVT. LTD., Ahmedabad

395002

RECRUITING

Nirmal Hospital Pvt. Ltd - Surat, Surat

400022

RECRUITING

K J Somaiya Super Specialty Hospital & Research Centre, Mumbai

682041

RECRUITING

Amrita Institute of Medical Sciences and Research Centre (AIMS), Kochi

0159

RECRUITING

K Eristavi National Center of Experimental and Clinical Surgery, Tbilisi

0160

RECRUITING

Medinvest Institute of Hematology and Transfusiology Limited, Tbilisi

NW1 2PG

RECRUITING

University College London Hospitals NHS Trust, London

W12 0HS

RECRUITING

Imperial College Healthcare NHS Trust, London

All Listed Sponsors
lead

Regeneron Pharmaceuticals

INDUSTRY