A Study to Investigate the Efficacy and Safety of Dato-DXd With or Without Osimertinib Compared With Platinum Based Doublet Chemotherapy in Participants With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

744

Participants

Timeline

Start Date

October 4, 2024

Primary Completion Date

June 11, 2026

Study Completion Date

May 29, 2028

Conditions
Metastatic Non-small Cell Lung Cancer
Interventions
DRUG

Dato-DXd

Dato-DXd will be administered as IV infusion.

DRUG

Osimertinib

Osimertinib will be administered orally.

DRUG

Pemetrexed

Pemetrexed will be administered as IV infusion.

DRUG

Carboplatin

Carboplatin will be administered as IV infusion.

DRUG

Cisplatin

Cisplatin will be administered as IV infusion.

Trial Locations (284)

100

Research Site, Taipei

110

Research Site, Taipei

112

Research Site, Taipei

404

Research Site, Taichung

1000

Research Site, Manila

1090

Research Site, Jette

1102

Research Site, Quezon

1104

Research Site, Quezon

1500

Research Site, San Juan City

2065

Research Site, St Leonards

2145

Research Site, Westmead

2170

Research Site, Liverpool

2217

Research Site, Kogarah

2444

Research Site, Port Macquarie

2650

Research Site, Edegem

3000

Research Site, Leuven

3084

Research Site, Heidelberg

3500

Research Site, Hasselt

4102

Research Site, Woolloongabba

5000

Research Site, Namur

5011

Research Site, Woodville

5505

Research Site, Seoul

6000

Research Site, Cebu City

6009

Research Site, Nedlands

6060

Research Site, Charleroi

6100

Research Site, Bacolod

7100

Research Site, La Louvière

7120

Research Site, Palma de Mallorca

8000

Research Site, Davao City

8800

Research Site, Roeselare

9000

Research Site, Ghent

10016

Research Site, New York

10043

Research Site, Orbassano

10065

Research Site, New York

10330

Research Site, Bangkok

10400

Research Site, Bangkok

10408

Research Site, Goyang-si

10461

Research Site, The Bronx

10700

Research Site, Bangkok

11526

Research Site, Athens

11527

Research Site, Athens

12120

Research Site, Pathum Thani

12351

Research Site, Berlin

12462

Research Site, Athens

13620

Research Site, Gyeonggi-do

13700

Research Site, Perai

14000

Research Site, Caen

14165

Research Site, Berlin-Zehlendorf

15009

Research Site, A Coruña

15232

Research Site, Pittsburgh

15706

Research Site, Santiago de Compostela-Coruña

16247

Research Site, Suwon

18547

Research Site, Athens

19107

Research Site, Philadelphia

20089

Research Site, Rozzano

20090

Research Site, Monza

20141

Research Site, Milan

20251

Research Site, Hamburg

20817

Research Site, Bethesda

21075

Research Site, Hamburg

21201

Research Site, Baltimore

22031

Research Site, Fairfax

22927

Research Site, Großhansdorf

23561

Research Site, New Taipei City

26121

Research Site, Oldenburg

28027

Research Site, Madrid

28046

Research Site, Madrid

28222

Research Site, Majadahonda

28644

Research Site, Chungcheongbuk-do

29004

Research Site, Málaga

30120

Research Site, El Palmar

30607

Research Site, Athens

31008

Research Site, Pamplona

31400

Research Site, Toulouse

32256

Research Site, Jacksonville

32608

Research Site, Gainesville

33006

Research Site, Oviedo

33076

Research Site, Bordeaux

33604

Research Site, Pessac

34298

Research Site, Montpellier

34362

Research Site, Haifa

35128

Research Site, Padua

35392

Research Site, Giessen

37000

Research Site, Tours

37126

Research Site, Verona

37203

Research Site, Nashville

37404

Research Site, Chattanooga

39008

Research Site, Santander

40002

Research Site, Khon Kaen

40207

Research Site, Louisville

40705

Research Site, Taichung

41014

Research Site, Seville

43126

Research Site, Parma

43537

Research Site, Maumee

44093

Research Site, Nantes

45122

Research Site, Essen

46010

Research Site, Valencia

46026

Research Site, Valencia

46050

Research Site, Kuala Selangor

47003

Research Site, Valladolid

47500

Research Site, Petaling Jaya

48108

Research Site, Busan

48202

Research Site, Detroit

48903

Research Site, Barakaldo

49100

Research Site, Petah Tikva

49124

Research Site, Georgsmarienhütte

49933

Research Site, Angers

50006

Research Site, Changhua

50200

Research Site, Chiang Mai

52621

Research Site, Ramat Gan

52727

Research Site, Jinju

56000

Research Site, Cheras

56249

Research Site, Thessaloniki

57001

Research Site, Thessaloniki

57010

Research Site, Thessaloniki

59037

Research Site, Lille

59100

Research Site, Kuala Lumpur

60201

Research Site, Evanston

60611

Research Site, Chicago

62748

Research Site, Tel Aviv

64132

Research Site, Kansas City

68124

Research Site, Omaha

70124

Research Site, Bari

70403

Research Site, Tainan City

71110

Research Site, Heraklion

72703

Research Site, Fayetteville

73657

Research Site, Tainan City

74245

Research Site, Löwenstein

75014

Research Site, Paris

75970

Research Site, Paris

80131

Research Site, Napoli

80528

Research Site, Fort Collins

80756

Research Site, Kaohsiung City

80909

Research Site, Colorado Springs

81100

Research Site, Johor Bahru

83800

Research Site, Toulon Armees

84902

Research Site, Avignon

90048

Research Site, Los Angeles

90110

Research Site, Hat Yai

90419

Research Site, Nuremberg

91010

Research Site, Duarte

91031

Research Site, Jerusalem

91120

Research Site, Jerusalem

92093

Research Site, La Jolla

92123

Research Site, San Diego

92708

Research Site, Fountain Valley

93586

Research Site, Kuching

94805

Research Site, Villejuif

95045

Research Site, Misterbianco

98104

Research Site, Seattle

100000

Research Site, Hanoi

100005

Research Site, Beijing

100034

Research Site, Beijing

100044

Research Site, Beijing

100050

Research Site, Beijing

100142

Research Site, Beijing

100730

Research Site, Beijing

101199

Research Site, Beijing

110004

Research Site, Shenyang

110042

Research Site, Shenyang

130012

Research Site, Changchun

130021

Research Site, Changchun

168583

Research Site, Singapore

200433

Research Site, Shanghai

210009

Research Site, Nanjing

217562

Research Site, Singapore

221005

Research Site, Varanasi

223399

Research Site, Huaian

230001

Research Site, Hefei

233004

Research Site, Bengbu

250013

Research Site, Jinan

261000

Research Site, Weifang

276000

Research Site, Linyi

300201

Research Site, Tianjin

308433

Research Site, Singapore

310003

Research Site, Hangzhou

310022

Research Site, Hangzhou

313001

Research Site, Rajasthan

330006

Research Site, Nanchang

341099

Research Site, Ganzhou

400012

Research Site, Mumbai

401107

Research Site, Thāne

410013

Research Site, Changsha

411001

Research Site, Pune

416234

Research Site, Kolhāpur

421001

Research Site, Hengyang

430060

Research Site, Wuhan

444606

Research Site, Amravati

450000

Research Site, Zhengzhou

450001

Research Site, Zhengzhou

450008

Research Site, Zhengzhou

471003

Research Site, Luoyang

492001

Research Site, Raipur

500034

Research Site, Hyderabad

510180

Research Site, Guangzhou

570017

Research Site, Mysuru

610041

Research Site, Chengdu

618000

Research Site, Deyang

637001

Research Site, Namakkal

646000

Research Site, Luzhou

695011

Research Site, Trivandrum

751019

Research Site, Bhubaneswar

834001

Research Site, Ranchi

999077

Research Site, Hong Kong

3109601

Research Site, Haifa

4428164

Research Site, Kfar Saba

8410101

Research Site, Beersheba

02114

Research Site, Boston

02215

Research Site, Boston

07960

Research Site, Morristown

08225

Research Site, Northfield

VIC3065

Research Site, Fitzroy

14784-400

Research Site, Barretos

32671-550

Research Site, Betim

89010-340

Research Site, Blumenau

88040-970

Research Site, Florianópolis

88301-220

Research Site, Itajaí

96020-080

Research Site, Pelotas

90035-074

Research Site, Porto Alegre

90470-340

Research Site, Porto Alegre

90610-000

Research Site, Porto Alegre

22250-905

Research Site, Rio de Janeiro

22281-100

Research Site, Rio de Janeiro

22775-001

Research Site, Rio de Janeiro

01323-900

Research Site, São Paulo

01327-001

Research Site, São Paulo

L6R 3J7

Research Site, Brampton

M4N 3M5

Research Site, Toronto

M5G 1Z5

Research Site, Toronto

H4A 3J1

Research Site, Montreal

G1R 2J6

Research Site, Québec

071000

Research Site, Baoding

Unknown

Research Site, Shantou

Research Site, Hong Kong

CN-300052

Research Site, Tianjin

552 36

Research Site, Thessaloniki

HKG

Research Site, Hong Kong

00000

Research Site, Shatin

06100

Research Site, Perugia

00144

Research Site, Roma

113-8431

Research Site, Bunkyō City

113-8603

Research Site, Bunkyō City

812-8582

Research Site, Fukuoka

734-8551

Research Site, Hiroshima

350-0495

Research Site, Iruma-Gun

740-8510

Research Site, Iwakuni-shi

650-0046

Research Site, Kobe

135-8550

Research Site, Kōtoku

860-8556

Research Site, Kumamoto

602-8566

Research Site, Kyoto

791-0280

Research Site, Matsuyama

464-8681

Research Site, Nagoya

466-8560

Research Site, Nagoya

951-8566

Research Site, Niigata

534-0021

Research Site, Osaka

541-8567

Research Site, Osaka

589-8511

Research Site, Ōsaka-sayama

981-0914

Research Site, Sendai

411-8777

Research Site, Sunto-gun

470-1192

Research Site, Toyoake-shi

320-0834

Research Site, Utsunomiya

641-8510

Research Site, Wakayama

236-0051

Research Site, Yokohama

241-8515

Research Site, Yokohama

05460

Research Site, Alor Star

40-519

Research Site, Katowice

30-727

Research Site, Krakow

90-302

Research Site, Lodz

10-357

Research Site, Olsztyn

60-569

Research Site, Poznan

03080

Research Site, Seoul

03722

Research Site, Seoul

06351

Research Site, Seoul

06591

Research Site, Seoul

08003

Research Site, Barcelona

08041

Research Site, Barcelona

08908

Research Site, L'Hospitalet de Llobregat

B9 5SS

Research Site, Birmingham

CB2 0QQ

Research Site, Cambridge

G12 0YN

Research Site, Glasgow

LE1 5WW

Research Site, Leicester

EC1A 7BE

Research Site, London

M20 4BX

Research Site, Manchester

TS4 3BW

Research Site, Middlesbrough

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY