Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers

NARecruitingINTERVENTIONAL
Enrollment

176

Participants

Timeline

Start Date

June 1, 2024

Primary Completion Date

November 30, 2026

Study Completion Date

November 30, 2026

Conditions
Alzheimer DiseaseCognitive Impairment
Interventions
OTHER

Acupuncture

The main acupoints are DU 24, EX-HN 3, DU 20, EX-HN 1, GB 12, HT 7, KI 6, GB39, and then selecting other acupoints according to TCM syndrome. There will be 12 weeks of 3-session treatment for each participant in total.

OTHER

Sham Acupuncture

The Streitberger placebo needle will be used to simulate an acupuncture procedure without penetrating the skin. The main acupoints are DU 24, EX-HN 3, DU 20, EX-HN 1, GB 12, HT 7, KI 6, GB39, and then selecting other acupoints according to TCM syndrome. There will be 12 weeks of 3-session treatment for each participant in total.

DRUG

Donepezil

Donepezil 5 mg will be given once daily before bed-time for 12 weeks.

Trial Locations (1)

200032

RECRUITING

Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai

All Listed Sponsors
collaborator

Shanghai Minimally Invasive Surgery Center

OTHER

lead

ZhanYJ

OTHER