The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy

NARecruitingINTERVENTIONAL
Enrollment

105

Participants

Timeline

Start Date

May 15, 2024

Primary Completion Date

October 10, 2024

Study Completion Date

October 20, 2024

Conditions
Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality
Interventions
DRUG

Dexmedetomidine administration

atients received dexmedetomidine (0.5 µg/kg over 10 min before the induction of anesthesia), and then dexmedetomidine was infused at a rate of 0.4 μg/kg/h until 20 min before the end of operation

DRUG

Dexmedetomidine plus low-dose esketamine administration

Patients received a bolus infusion of dexmedetomidine (0.5 µg/kg) and esketamine (0.5 mg/kg)over 10 min before the induction of anesthesia, and then dexmedetomidine were infused at a rate of 0.4 µg/kg/h and 2 µg/kg/min until 20 min before the end of operation, respectively.

DRUG

Dexmedetomidine plus high-dose esketamine administration

Patients received a bolus infusion of dexmedetomidine (0.5 µg/kg) and esketamine (0.5 mg/kg)over 10 min before the induction of anesthesia, and then dexmedetomidine were infused at a rate of 0.4 µg/kg/h and 4 µg/kg/min until 20 min before the end of operation, respectively.

Trial Locations (1)

246003

RECRUITING

Department of Anqing Hospital Anesthesiology, Anqing

All Listed Sponsors
lead

Anqing Municipal Hospital

OTHER