34
Participants
Start Date
January 10, 2024
Primary Completion Date
January 30, 2024
Study Completion Date
June 30, 2026
Exercise training (ET1+ET2)
Exercise training will consist of continuous aerobic training of moderate intensity on cycle ergometer/treadmill, with a frequency of 2-3 weekly sessions lasting 12 weeks, with exercise intensity of VO2 peak of 40% gradually increasing up to 50-60% of VO2 peak based on individual tolerability and improvement; 55-65% of heart rate at peak; 40-59% of heart rate reserve; 4-6 Metabolic equivalents (METS); the duration of the session will gradually increase from 15-30 min to 45-60 min.
Optimal Medical Therapy (No-ET)
Patients will be handled according to optimal medical therapy
Department of Translational Medical Sciences, Naples
Federico II University
OTHER