Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study

NARecruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

June 1, 2024

Primary Completion Date

June 1, 2025

Study Completion Date

July 1, 2025

Conditions
Postoperative Analgesia
Interventions
DRUG

Oliceridine fumarate low dose

The first loading dose of oliceridine fumarate was 1.5 mg in all patients after operation. The PCA dose of the patients was 0.1 mg, and the locking interval was 6 min. A supplemental dose of 0.75 mg is allowed once per hour as needed after 1 h of the load dose

DRUG

Oliceridine fumarate high dose

The first loading dose of oliceridine fumarate was 1.5 mg in all patients after operation. The PCA dose of the patients was 0.5 mg, and the locking interval was 6 min. A supplemental dose of 0.75 mg is allowed once per hour as needed after 1 h of the load dose

DRUG

Oliceridine fumarate moderate dose

The first loading dose of oliceridine fumarate was 1.5 mg in all patients after operation. The PCA dose of the patients was 0.35 mg, and the locking interval was 6 min. A supplemental dose of 0.75 mg is allowed once per hour as needed after 1 h of the load dose

DRUG

morphine

The first loading dose of morphine was 4 mg in all patients after operation. The PCA dose of the patients was 1 mg, and the locking interval was 6 min. A supplemental dose of 2 mg is allowed once per hour as needed after 1 h of the load dose; The maximum cumulative daily dose is 60 mg.

Trial Locations (1)

Unknown

RECRUITING

Tongji Hospital, Wuhan

All Listed Sponsors
lead

Tongji Hospital

OTHER