The Efficacy and Safety of Levetiracetam Versus Fosphenytoin in Convulsive Status Epilepticus

PHASE4Enrolling by invitationINTERVENTIONAL
Enrollment

62

Participants

Timeline

Start Date

May 15, 2023

Primary Completion Date

August 31, 2024

Study Completion Date

October 31, 2024

Conditions
Status Epilepticus
Interventions
DRUG

Levetiracetam Injection

Levetiracetam at 60 mg/kg (max dose 4500 mg) will be intravenously administered in 100mL of normal saline at an administration rate of 2-5mg/kg/min or over 10 minutes. After 30 minutes following Levetiracetam needle time reassessment of the patient will be done to determine the outcomes.

DRUG

Fosphenytoin Injection

Fosphenytoin at 20 mg/kg (Phenytoin equivalent dose of 15 mg/kg) will be intravenously administered in 100mL of normal saline at an administration rate not exceeding 3mg/kg/min or 150 mg/min. After 30 minutes following the Fosphenytoin needle time reassessment of the patient will be done to determine the outcomes.

Trial Locations (1)

1000

Dhaka Medical College Hospital, Dhaka

Sponsors
All Listed Sponsors
lead

Dhaka Medical College

OTHER