A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,656

Participants

Timeline

Start Date

April 15, 2025

Primary Completion Date

February 13, 2031

Study Completion Date

February 13, 2031

Conditions
Stage I Mixed Cell Type Kidney Wilms TumorStage II Mixed Cell Type Kidney Wilms TumorStage III Mixed Cell Type Kidney Wilms TumorStage IV Mixed Cell Type Kidney Wilms Tumor
Interventions
PROCEDURE

Bone Scan

Undergo bone scan for patients with metastatic sites outside the chest/abdomen/pelvis documented during therapy

DRUG

Carboplatin

Given IV

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Cyclophosphamide

Given IV

BIOLOGICAL

Dactinomycin

Given IV

DRUG

Doxorubicin

Given IV

DRUG

Etoposide

Given IV

DRUG

Irinotecan

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Nephrectomy

Undergo nephrectomy

OTHER

Patient Observation

Undergo observation after nephrectomy

PROCEDURE

Positron Emission Tomography

Undergo PET for patients with metastatic sites outside the chest/abdomen/pelvis documented during therapy

PROCEDURE

Ultrasound Imaging

Undergo ultrasound

DRUG

Vincristine

Given IV

PROCEDURE

X-Ray Imaging

Undergo X-ray

Trial Locations (106)

10595

RECRUITING

New York Medical College, Valhalla

11501

RECRUITING

NYU Langone Hospital - Long Island, Mineola

11794

RECRUITING

Stony Brook University Medical Center, Stony Brook

12208

RECRUITING

Albany Medical Center, Albany

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

17033

RECRUITING

Penn State Children's Hospital, Hershey

17822

RECRUITING

Geisinger Medical Center, Danville

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21201

RECRUITING

University of Maryland/Greenebaum Cancer Center, Baltimore

21215

RECRUITING

Sinai Hospital of Baltimore, Baltimore

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23298

RECRUITING

VCU Massey Comprehensive Cancer Center, Richmond

23507

RECRUITING

Children's Hospital of The King's Daughters, Norfolk

24014

RECRUITING

Carilion Children's, Roanoke

27710

RECRUITING

Duke University Medical Center, Durham

27834

RECRUITING

East Carolina University, Greenville

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

29605

RECRUITING

BI-LO Charities Children's Cancer Center, Greenville

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

32207

RECRUITING

Nemours Children's Clinic-Jacksonville, Jacksonville

32504

RECRUITING

Nemours Children's Clinic - Pensacola, Pensacola

32806

RECRUITING

Arnold Palmer Hospital for Children, Orlando

32827

RECRUITING

Nemours Children's Hospital, Orlando

33021

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33316

RECRUITING

Broward Health Medical Center, Fort Lauderdale

33407

RECRUITING

Saint Mary's Medical Center, West Palm Beach

35233

RECRUITING

Children's Hospital of Alabama, Birmingham

37232

RECRUITING

Vanderbilt University/Ingram Cancer Center, Nashville

37916

RECRUITING

East Tennessee Childrens Hospital, Knoxville

38105

NOT_YET_RECRUITING

Saint Jude Children's Research Hospital, Memphis

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40536

RECRUITING

University of Kentucky/Markey Cancer Center, Lexington

43606

RECRUITING

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital, Toledo

44308

RECRUITING

Children's Hospital Medical Center of Akron, Akron

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

45404

RECRUITING

Dayton Children's Hospital, Dayton

46202

RECRUITING

Riley Hospital for Children, Indianapolis

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

48201

RECRUITING

Children's Hospital of Michigan, Detroit

49007

RECRUITING

Bronson Methodist Hospital, Kalamazoo

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

54301

RECRUITING

Saint Vincent Hospital Cancer Center Green Bay, Green Bay

55455

RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

60611

RECRUITING

Lurie Children's Hospital-Chicago, Chicago

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

61637

RECRUITING

Saint Jude Midwest Affiliate, Peoria

63104

RECRUITING

Cardinal Glennon Children's Medical Center, St Louis

63110

RECRUITING

Washington University School of Medicine, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

68198

RECRUITING

University of Nebraska Medical Center, Omaha

70118

RECRUITING

Children's Hospital New Orleans, New Orleans

70121

RECRUITING

Ochsner Medical Center Jefferson, New Orleans

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75230

RECRUITING

Medical City Dallas Hospital, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

76104

RECRUITING

Cook Children's Medical Center, Fort Worth

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

78207

RECRUITING

Children's Hospital of San Antonio, San Antonio

78229

RECRUITING

Methodist Children's Hospital of South Texas, San Antonio

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

79106

RECRUITING

Texas Tech University Health Sciences Center-Amarillo, Amarillo

79410

RECRUITING

Covenant Children's Hospital, Lubbock

79415

RECRUITING

UMC Cancer Center / UMC Health System, Lubbock

80045

RECRUITING

Children's Hospital Colorado, Aurora

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

84113

RECRUITING

Primary Children's Hospital, Salt Lake City

85016

RECRUITING

Phoenix Childrens Hospital, Phoenix

85202

RECRUITING

Banner Children's at Desert, Mesa

89135

RECRUITING

Alliance for Childhood Diseases/Cure 4 the Kids Foundation, Las Vegas

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

92123

RECRUITING

Rady Children's Hospital - San Diego, San Diego

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

92868

RECRUITING

Children's Hospital of Orange County, Orange

93636

RECRUITING

Valley Children's Hospital, Madera

94304

RECRUITING

Lucile Packard Children's Hospital Stanford University, Palo Alto

94611

RECRUITING

Kaiser Permanente-Oakland, Oakland

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

97227

RECRUITING

Legacy Emanuel Children's Hospital, Portland

98405

RECRUITING

Mary Bridge Children's Hospital and Health Center, Tacoma

99204

RECRUITING

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

99508

RECRUITING

Providence Alaska Medical Center, Anchorage

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

04074

RECRUITING

Maine Children's Cancer Program, Scarborough

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

01655

RECRUITING

UMass Memorial Medical Center - University Campus, Worcester

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07601

RECRUITING

Hackensack University Medical Center, Hackensack

07753

RECRUITING

Jersey Shore Medical Center, Neptune City

08901

RECRUITING

Saint Peter's University Hospital, New Brunswick

08903

RECRUITING

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

02903

RECRUITING

Rhode Island Hospital, Providence

R3E 0V9

RECRUITING

CancerCare Manitoba, Winnipeg

B3K 6R8

RECRUITING

IWK Health Centre, Halifax

K1H 8L1

RECRUITING

Children's Hospital of Eastern Ontario, Ottawa

M5G 1X8

RECRUITING

Hospital for Sick Children, Toronto

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine, Montreal

J1H 5N4

RECRUITING

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

G1V 4G2

RECRUITING

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec

All Listed Sponsors
lead

Children's Oncology Group

NETWORK