Measurement of Blood Loss in Adenotonsillectomy During General Anesthesia According to the Application of Nondepolarizing Muscle Relaxants

PHASE4RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

April 18, 2024

Primary Completion Date

June 30, 2025

Study Completion Date

October 31, 2025

Conditions
AnesthesiaNeuromuscular BlockadeIntraoperative BleedingIntraoperative Blood LossPost Operative HemorrhageAnesthesia Complication
Interventions
PROCEDURE

conventional cold tonsillectomy and curettage adenoidectomy

After entering the operating room, the children will be monitored (electrodes for ECG, blood pressure cuff and pulse oximeter). We will use gas mixture of O2/N20 50/50% and concentration of Sevoflurane set between 5% and 6 % with a dose of 6 L/min (1.0 -1.3 MAC) for 10 breaths, then we will set 4 % concentration of Sevoflurane. After loss of consciousness, intravenous line 22 G will be obtained and 0.9 % saline infuse with a dose of 4 ml/kg/hr, Fentanyl 1 mcg/kg iv. and Propofol 2 mg/kg. During stage III of anesthetic depth, we will perform orotracheal intubation.

DRUG

Rocuronium Bromide

After entering the operating room, chlidren will be monitored (electrodes for ECG, blood pressure cuff and pulse oximeter). We will use gas mixture of O2/N20 50/50% and concentration of Sevoflurane set between 5% and 6 % with a dose of 6 L/min (1.0 -1.3 MAC) for 10 breaths. After loss of consciousness, we will turn off Sevoflurane, intravenous line 22 G will be obtained and 0.9 % saline infuse with a dose of 4 ml/kg/hr, 1 mcg/kg Fentanyl, 2.5 mg/kg Propofol and 0.6 mg/kg Rocuronium bromide (esmeron). After 2 min, orotracheal intubation will be performed.

Trial Locations (1)

21000

RECRUITING

University Hospital Split, Split

All Listed Sponsors
lead

University Hospital of Split

OTHER