Proactive TDM Versus Standard Use of Biologics in Psoriasis

PHASE4RecruitingINTERVENTIONAL
Enrollment

210

Participants

Timeline

Start Date

December 20, 2024

Primary Completion Date

March 1, 2028

Study Completion Date

March 1, 2028

Conditions
Psoriasis Vulgaris
Interventions
DRUG

Proactive TDM-based dosing of secukinumab

"Maintenance/normal dose is 300 mg/4 weeks.~First dose reduction step: 300 mg/6 weeks. Second dose reduction step: 300 mg/8 weeks. Further dose reduction steps: prolongation with 1 additional week~First dose escalation step: 300 mg/3 weeks Second dose escalation step: 300 mg/2 weeks Further dose escalation step: shortening with 1 additional week"

DRUG

Proactive TDM-based dosing of ixekizumab

"Maintenance/normal dose is 80 mg/4 weeks.~First dose reduction step: 80 mg/6 weeks. Second dose reduction step: 80 mg/8 weeks Further dose reduction steps: prolongation with 1 additional week~First dose escalation step: 80 mg/3 weeks Second dose escalation step: 80 mg/2 weeks Further dose escalation step: shortening with 1 additional week"

DRUG

Proactive TDM-based dosing of guselkumab

"Maintenance/normal dose is 100 mg/8 weeks.~First dose reduction step: 100 mg/12 weeks. Second dose reduction step: 100 mg/16 weeks. Further dose reduction steps: prolongation with 1 additional week~First dose escalation step: 100 mg/6 weeks Second dose escalation step: 100 mg/4 weeks Further dose escalation step: shortening with 1 additional week"

Trial Locations (13)

9900

NOT_YET_RECRUITING

AZ Alma, Eeklo

Unknown

RECRUITING

AZ Sint-Jan, Bruges

RECRUITING

UCL Saint-Luc, Brussels

NOT_YET_RECRUITING

ULB Erasme, Brussels

NOT_YET_RECRUITING

UZ Brussel, Brussels

NOT_YET_RECRUITING

Grand Hôpital de Charleroi, Charleroi

NOT_YET_RECRUITING

Dermatologiepraktijk huidziekten Geel, Geel

RECRUITING

AZ Maria Middelares, Ghent

RECRUITING

UZ Gent, Ghent

RECRUITING

Clinique André Renard, Herstal

RECRUITING

Dermatologie Handelskaai, Kortrijk

NOT_YET_RECRUITING

UZ Leuven, Leuven

RECRUITING

Dermatologie Maldegem, Maldegem

All Listed Sponsors
collaborator

Belgium Health Care Knowledge Centre

OTHER_GOV

lead

University Hospital, Ghent

OTHER