Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

August 16, 2024

Primary Completion Date

March 31, 2029

Study Completion Date

March 31, 2029

Conditions
B-cell Acute Lymphoblastic LeukemiaDiffuse Large B-cell LymphomaBurkitt LymphomaNeuroblastomaEwing Sarcoma
Interventions
BIOLOGICAL

Zilovertamab vedotin

Administered via IV infusion

Trial Locations (60)

1085

RECRUITING

Semmelweis Egyetem ( Site 1838), Budapest

2031

RECRUITING

Sydney Children's Hospital-Kids Cancer Centre ( Site 1997), Randwick

4101

RECRUITING

Queensland Children's Hospital-Oncology & Haematology ( Site 1996), Brisbane

9000

RECRUITING

UZ Gent ( Site 1428), Ghent

10002

RECRUITING

National Taiwan University Hospital ( Site 1983), Taipei

10126

RECRUITING

Ospedale Infantile Regina Margherita-S.C. Oncoematologia Pediatrica ( Site 1551), Torino

10595

RECRUITING

New York Medical College ( Site 1023), Valhalla

13005

RECRUITING

Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone ( Site 1102), Marseille

13353

RECRUITING

Charité Campus Virchow-Klinikum-Klinik für Pädiatrie mit Schwerpunkt Hämatologie und Onkologie ( Site 1143), Berlin

19104

RECRUITING

Children's Hospital of Philadelphia (CHOP) ( Site 1021), Philadelphia

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori-Pediatric Oncology ( Site 1552), Milan

28009

RECRUITING

Hospital Infantil Universitario Niño Jesús-Servicio de Onco-Hematología Pediátrica ( Site 1715), Madrid

33076

RECRUITING

CHU de Bordeaux. Hopital Pellegrin ( Site 1105), Bordeaux

33701

RECRUITING

Johns Hopkins All Children's Hospital ( Site 1025), St. Petersburg

35100

RECRUITING

Ege Universitesi Hastanesi ( Site 1963), Izmir

44093

RECRUITING

Centre Hospitalier Universitaire de Nantes - Hôpital Femme-Enfant-Adolescent Chu De Nantes ( Site 1104), Nantes

48149

RECRUITING

Universitätsklinikum Münster - Albert Schweitzer Campus-Pädiatrische Hämatologie und Onkologie ( Site 1141), Münster

49503

RECRUITING

Corewell Health ( Site 1001), Grand Rapids

52242

RECRUITING

University of Iowa-Holden Comprehensive Cancer Center ( Site 1017), Iowa City

57105

RECRUITING

Sanford Children's Hospital-Sanford Children's Specialty Clinic ( Site 1015), Sioux Falls

58122

RECRUITING

Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 1003), Fargo

64108

RECRUITING

Children's Mercy Hospital ( Site 1024), Kansas City

69373

RECRUITING

CENTRE LEON BERARD-IHOPE (pediatrric oncology) ( Site 1100), Lyon

77030

RECRUITING

University of Texas MD Anderson Cancer Center ( Site 1007), Houston

80045

RECRUITING

Children's Hospital Colorado-Center for Cancer and Blood Disorders ( Site 1016), Aurora

84113

RECRUITING

Intermountain - Primary Children's Hospital ( Site 1014), Salt Lake City

90027

RECRUITING

Children's Hospital Los Angeles ( Site 1006), Los Angeles

94805

RECRUITING

Gustave Roussy ( Site 1103), Villejuif

97239

RECRUITING

Oregon Health and Science University ( Site 1004), Portland

230002

RECRUITING

IMAT S.A.S ( Site 1921), Montería

2341131

RECRUITING

Hospital Carlos Van Buren ( Site 1880), Valparaíso

3109601

RECRUITING

Rambam Health Care Campus-Pediatric Hemato-Oncology ( Site 1674), Haifa

5265601

RECRUITING

Sheba Medical Center ( Site 1675), Ramat Gan

14784400

RECRUITING

Fundação Pio XII - Hospital de Câncer de Barretos ( Site 1264), Barretos

15090000

RECRUITING

Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site 1267), São José do Rio Preto

06510

RECRUITING

Yale-New Haven Hospital ( Site 1012), New Haven

02215

RECRUITING

Dana-Farber Cancer Institute ( Site 1013), Boston

08901

RECRUITING

Rutgers Cancer Institute of New Jersey ( Site 1008), New Brunswick

81520-060

RECRUITING

Hospital Erasto Gaertner-CEPEP - Pesquisa Clínica ( Site 1268), Curitiba

90035-903

RECRUITING

Hospital de Clinicas de Porto Alegre ( Site 1265), Porto Alegre

H4A 3J1

RECRUITING

McGill University Health Centre-Pediatric HematologyOncology ( Site 1223), Montreal

050034

RECRUITING

Hospital Pablo Tobon Uribe ( Site 1923), Medellín

080020

RECRUITING

Clinica de la Costa S.A.S.-Clinical Research Oncology & Hematology -Pediatric ( Site 1924), Barranquilla

150 00

RECRUITING

Fakultni nemocnice v Motole-Klinika detske hematologie a onkologie ( Site 1387), Prague

DK-2100

RECRUITING

Rigshospitalet-Department of paediatrics and adolescent medicine, Section of Paed haem-onc ( Site 1467), Copenhagen

115 27

RECRUITING

Aghia Sophia Children's Hospital-First Department of Pediatrics, National and Kapodistrian Universi ( Site 1797), Athens

00165

RECRUITING

Ospedale Pediatrico Bambino Gesù IRCCS-Dipartimento di Onco-Ematologia e Terapia Cellulare e Genica ( Site 1553), Rome

3584 CS

RECRUITING

Prinses Maxima Centrum voor Kinderoncologie ( Site 1510), Utrecht

831 01

RECRUITING

Narodny ustav detskych chorob ( Site 1592), Bratislava

03080

RECRUITING

Seoul National University Hospital-Pediatrics ( Site 1972), Seoul

05505

RECRUITING

Asan Medical Center-Pediatrics - Pedicatric Oncology ( Site 1973), Seoul

08950

RECRUITING

Hospital Sant Joan de Déu-Pediatric Oncology Department ( Site 1717), Esplugas de Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Servei de Hematologia i Oncologia Pediatrica ( Site 1716), Barcelona

416 85

RECRUITING

Prövningsenhet barn, Sahlgrenska Universitetssjukhuset ( Site 1634), Gothenburg

06230

RECRUITING

Hacettepe Universite Hastaneleri ( Site 1961), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi ( Site 1962), Ankara

NE1 4PL

RECRUITING

Royal Victoria Infirmary-Great North Children's Hospital ( Site 1348), Newcastle upon Tyne

NW1 2PG

RECRUITING

University College London Hospital ( Site 1350), London

SM2 5PT

RECRUITING

Royal Marsden Hospital (Sutton)-Drug Development Unit ( Site 1347), Sutton

CF14 4XW

RECRUITING

University Hospital of Wales ( Site 1346), Cardiff

All Listed Sponsors
lead

Merck Sharp & Dohme LLC

INDUSTRY