NCT06393400View on ClinicalTrials.gov

CHemotherapy and Stool Transplant in PDAC (CHASe-PDAC)

PHASE1RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

January 8, 2025

Primary Completion Date

February 29, 2028

Study Completion Date

February 29, 2028

Conditions
Unresectable or Metastatic Advanced Pancreatic Ductal Adenocarcinoma
Interventions
DRUG

Fecal Microbiota Transplantation

"Fecal Microbiota Transplantation with 100 g of healthy donor stool in 36-40 oral capsules once~Other Names:~* FMT~* Stool Transplant~* Poop Transplant"

DRUG

PEG3350

"Polyethylene Glycol 3350 17 g oral dissolved in 4 litres of water consumed the evening before FMT.~Other Names:~* PEG3350~* RestoraLAX~* MiraLAX"

DRUG

Gemcitabine

"Gemcitabine 1000 mg/m2/day IV on Days 1, 8, and 15 of each 28-day cycle.~Other Names:~\- Gemzar"

DRUG

nab-Paclitaxel

"nab-Paclitaxel 125 mg/m2/day IV on Days 1, 8, and 15 of each 28-day cycle.~Other Names:~\- Abraxane"

Trial Locations (1)

N6A 5W9

RECRUITING

Verspeeten Family Cancer Centre (formerly known as the London Regional Cancer Program) London Health Sciences Centre, London

All Listed Sponsors
lead

John Lenehan

OTHER