NCT06392295View on ClinicalTrials.gov

PSMA-Directed Para-Aortic Radiation Therapy for Oligorecurrent Prostate Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

July 3, 2024

Primary Completion Date

August 1, 2027

Study Completion Date

August 1, 2029

Conditions
Prostate CancerProstate AdenocarcinomaHormone Sensitive Prostate Cancer
Interventions
RADIATION

Para Aortic Radiation Therapy: Photon Therapy

Participants will undergo five weeks of PA-RT daily, for up to 30 minutes per day for 25 days, Monday through Friday, consisting of a total dose of 50 grays (Gys) delivered in 25 fractions to the Clinical Tumor Volume (CTV).

RADIATION

Para Aortic Radiation Therapy: Proton Therapy

Participants will undergo five weeks of PA-RT daily, for up to 30 minutes per day for 25 days, Monday through Friday, consisting of a total dose of 60 to 65 Gys delivered in 25 fractions to the Gross Tumor Volume (GTVn).

DRUG

Androgen Deprivation Therapy

Androgen deprivation therapy will be administered as per standard of care.

DRUG

Androgen Receptor Signaling Inhibitor

Androgen receptor signaling inhibitor (ARSI) will be administered as per standard of care.

Trial Locations (1)

33136

RECRUITING

University of Miami, Miami

All Listed Sponsors
lead

University of Miami

OTHER