The Efficacy and Safety of Third-generation TKIs Combined With Azacitidine and Bcl-2 Inhibitor in Patients With CML-MBP

RecruitingOBSERVATIONAL
Enrollment

30

Participants

Timeline

Start Date

July 1, 2024

Primary Completion Date

December 1, 2026

Study Completion Date

December 1, 2027

Conditions
Chronic Myeloid Leukemia
Interventions
DRUG

Ponatinib

Ponatinib is recommended orally (PO) daily continuously on days 1-28 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.

DRUG

Azacitidine

Azacitidine is recommended 75mg/m2 subcutaneously on days 1-7 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.

DRUG

Venetoclax

Venetoclax is recommended orally (PO) daily on days 1-14 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.

DRUG

Olverembatinib

Olverembatinib is recommended orally (PO) every other day on days 1-28 in 28-day cycle. Treatment repeats every 28 days in the absence of disease progression, unacceptable toxicity or HSCT.

Trial Locations (15)

100044

RECRUITING

Peking university people's hospital, Beijing

Unknown

RECRUITING

Beijing Lu Daopei Hospital, Beijing

NOT_YET_RECRUITING

Chuiyangliu hospital affiliated to tsinghua university, Beijing

NOT_YET_RECRUITING

Sichuan Provincial People's Hospital, Chengdu

NOT_YET_RECRUITING

Nanfang Hospital, Southern Medical University, Guangdong

NOT_YET_RECRUITING

The First Affiliated Hospital of Kunming Medical University, Kunming

RECRUITING

The First Affiliated Hospital of Nanjing Medical University, Nanjing

RECRUITING

The First Affiliated Hospital of Guangxi Medical University, Nanning

RECRUITING

Nanyang Central Hospital, Nanyang

RECRUITING

Ningbo Medical Center Lihuili Hospital, Ningbo

NOT_YET_RECRUITING

Qilu Hospital of Shandong University, Qilu

NOT_YET_RECRUITING

Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Tianjin

NOT_YET_RECRUITING

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Henan Cancer Hospital, Wuhan

RECRUITING

Xi'an International Medical Center Hospital, Xi'an

RECRUITING

The First Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang

All Listed Sponsors
collaborator

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

collaborator

Henan Cancer Hospital

OTHER_GOV

collaborator

Zhejiang University

OTHER

collaborator

Peking Union Medical College

OTHER

collaborator

Nanfang Hospital, Southern Medical University

OTHER

collaborator

Beijing Chuiyangliu Hospital

OTHER_GOV

lead

Peking University People's Hospital

OTHER