A Study to Evaluate the Safety and Efficacy of Axatilimab in Combination With Ruxolitinib in Participants With Newly Diagnosed Chronic Graft-Versus-Host Disease

PHASE2RecruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

October 11, 2024

Primary Completion Date

June 1, 2027

Study Completion Date

December 1, 2029

Conditions
Chronic Graft-versus-host-disease
Interventions
DRUG

Axatilimab

Axatilimab will be administered at protocol defined dose.

DRUG

Ruxolitinib

Ruxolitinib will be administered at protocol defined dose.

DRUG

Corticosteroids

Corticosteroids will be administered at protocol defined dose.

Trial Locations (70)

10021

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

RECRUITING

Weill Cornell Medicine, New York

10029

RECRUITING

Mount Sinai Hospital, New York

10126

RECRUITING

A.O.U. Citta Della Salute E Della Scienza Di Torino, Torino

15232

RECRUITING

Hillman Cancer Center, Pittsburgh

18014

RECRUITING

Hospital Universitario Virgen de Las Nieves, Granada

19104

RECRUITING

University of Pennsylvania Abramson Cancer Center, Philadelphia

20089

RECRUITING

Irccs Istituto Clinico Humanitas, Rozzano

20122

RECRUITING

Fondazione Irccs Ca Granda Ospedale Maggiore Policlinico Di Milano Uo Dermatologia, Milan

20251

RECRUITING

Universitatsklinikum Hamburg Eppendorf, Hamburg

21201

RECRUITING

University of Maryland-Greenebaum Cancer Center, Baltimore

24127

RECRUITING

Azienda Socio Sanitaria Territoriale Papa Giovanni Xxiii, Bergamo

28007

RECRUITING

Hospital General Universitario Gregorio Maranon, Madrid

28034

RECRUITING

Hospital Universitario Ramon Y Cajal, Madrid

28041

RECRUITING

Hospital Universitario 12 de Octubre, Madrid

29011

RECRUITING

Hospital Regional Universitario de Malaga, Málaga

30120

RECRUITING

Hospital Universitario Virgen de La Arrixaca, El Palmar

32224

NOT_YET_RECRUITING

Mayo Clinic Jacksonville, Jacksonville

37007

RECRUITING

Hospital Clinico Universitario de Salamanca, Salamanca

37232

RECRUITING

Vanderbilt University Medical Center, Nashville

39008

RECRUITING

Hospital Universitario Marques de Valdecilla, Santander

40138

RECRUITING

Aou Policlinico S. Orsola-Malpighi, Bologna

41013

RECRUITING

Hospital Universitario Virgen Del Rocio, Seville

43210

RECRUITING

The Ohio State University, Columbus

44195

RECRUITING

Cleveland Clinic, Cleveland

46010

RECRUITING

Hospital Clinico Universitario de Valencia, Valencia

46026

RECRUITING

Hospital Universitari I Politecnic La Fe, Valencia

53226

RECRUITING

Froedtert & the Medical College of Wisconsin, Milwaukee

60590

RECRUITING

Klinikum Der Johann Wolfgang Goethe University, Frankfurt am Main

60611

RECRUITING

Northwestern University, Chicago

60637

NOT_YET_RECRUITING

The University of Chicago Medicine, Chicago

63110

RECRUITING

Washington University, St Louis

68167

RECRUITING

University Hospital Mannheim, Mannheim

68198

RECRUITING

Fred and Pamela Buffett Cancer Center, Omaha

77030

RECRUITING

Md Anderson Cancer Center, Houston

79106

RECRUITING

Universitatklinikum Freiburg, Freiburg im Breisgau

80045

RECRUITING

University of Colorado Cancer Center, Aurora

80218

RECRUITING

Colorado Blood Cancer Institute, Denver

85054

NOT_YET_RECRUITING

Mayo Clinic Hospital, Phoenix

90095

RECRUITING

University of California-Los Angeles Medl Cntr-Oncology Center Bowyer Clinic, Los Angeles

91010

RECRUITING

City of Hope Medical Center, Duarte

93053

RECRUITING

Universitaetsklinikum Regensburg, Regensburg

94305

RECRUITING

Stanford Cancer Center, Stanford

98105

NOT_YET_RECRUITING

Seattle Children'S Hospital, Seattle

98109

NOT_YET_RECRUITING

Fred Hutchinson Cancer Center, Seattle

06510

RECRUITING

Smilow Cancer Center-Yale, New Haven

02144

WITHDRAWN

Massachusetts General Hospital, Boston

08000

RECRUITING

Az Sint-Jan Brugge - Oostende Av - Campus Sint-Jan, Bruges

02650

RECRUITING

Universitair Ziekenhuis Antwerpen (Uza), Edegem

03500

RECRUITING

Jessa Ziekenhuis, Hasselt

03000

RECRUITING

Universitair Ziekenhuis (Uz) Leuven, Leuven

RECRUITING

Universitaire Ziekenhuis Leuven - Gasthuisberg, Leuven

04000

RECRUITING

Centre Hospitalier Universitaire (Chu) de Liege, Liège

08800

RECRUITING

AZ DELTA, Roeselare

T3N 4N1

RECRUITING

Arthur J E Child Comprehensive Cancer Centre, Calgary

M5G 2M9

RECRUITING

Princess Margaret Cancer Centre - University Health Network, Toronto

H3T 1C5

RECRUITING

Chu Sainte-Justine, Montreal

V5Z1M9

RECRUITING

Vancouver General Hospital, Vancouver

07747

RECRUITING

Universitaetsklinikum Jena, Jena

00165

RECRUITING

Ospedale Pediatrico Bambino Gesu Irccs, Rome

00168

RECRUITING

Policlinico Universitario Agostino Gemelli Universita Cattolica Del Sacro Cuore, Rome

08035

WITHDRAWN

Hospital General Universitario Vall D Hebron, Barcelona

08036

RECRUITING

Hospital Clinic Barcelona Main, Barcelona

08908

RECRUITING

Ico Institut Catala D Oncologia, Granvia de L'hospitalet 199-203

B15 2TH

RECRUITING

Queen Elizabeth Hospital, Birmingham

CB2 0QQ

RECRUITING

Cambridge University Hospitals Nhs Foundation Trust, Cambridge

CF14 4XW

RECRUITING

University Hospital of Wales, Cardiff

G51 4TF

RECRUITING

Queen Elizabeth University Hospital, Glasgow

LS9 7TF

RECRUITING

St James University Hospital, Leeds

L7 8YA

RECRUITING

Clatterbridge Cancer Center, Liverpool

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Incyte Corporation

INDUSTRY