Saruparib (AZD5305) Plus Camizestrant Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

500

Participants

Timeline

Start Date

August 1, 2024

Primary Completion Date

March 30, 2029

Study Completion Date

October 18, 2030

Conditions
Advanced Breast Cancer
Interventions
DRUG

Saruparib (AZD5305)

Saruparib (AZD5305) is a potent and selective inhibitor of PARP1, with minimal effect on PARP2.

DRUG

Camizestrant

Camizestrant (AZD9833) is an orally bioavailable, next generation SERD with non-clinical and clinical activity in both ESR1 mutant and wild type settings .

DRUG

Abemaciclib

CDK4/6 Inhibitor

DRUG

Ribociclib

CDK4/6 Inhibitor

DRUG

Palbociclib

CDK 4/6 Inhibitor

DRUG

Fulvestrant

Endocrine Therapy

DRUG

Letrozole

Endorcine Therapy

DRUG

Anastrozole

Endocrine Therapy

DRUG

Exemestane

Endocrine Therapy

Trial Locations (281)

100

RECRUITING

Research Site, Taipei

112

RECRUITING

Research Site, Taipei

704

RECRUITING

Research Site, Tainan City

1015

RECRUITING

Research Site, Ciudad de Buenos Aires

1082

NOT_YET_RECRUITING

Research Site, Budapest

1090

RECRUITING

Research Site, Vienna

1122

NOT_YET_RECRUITING

Research Site, Budapest

1125

RECRUITING

Research Site, Ciudad Autónoma Buenos Aires

1145

RECRUITING

Research Site, Budapest

1527

NOT_YET_RECRUITING

Research Site, Sofia

2010

RECRUITING

Research Site, Darlinghurst

2139

RECRUITING

Research Site, Darlinghurst

3000

NOT_YET_RECRUITING

Research Site, Vratsa

3144

WITHDRAWN

Research Site, Malvern

3526

RECRUITING

Research Site, Miskolc

3722

RECRUITING

Research Site, Seoul

4000

NOT_YET_RECRUITING

Research Site, San Miguel de Tucumán

4002

RECRUITING

Research Site, Plovdiv

4010

RECRUITING

Research Site, Linz

5008

RECRUITING

Research Site, Córdoba

5505

RECRUITING

Research Site, Seoul

6003

NOT_YET_RECRUITING

Research Site, Stara Zagora

8036

RECRUITING

Research Site, Graz

8900

NOT_YET_RECRUITING

Research Site, Zalaegerszeg

10003

NOT_YET_RECRUITING

Research Site, Cáceres

10016

RECRUITING

Research Site, New York

10028

RECRUITING

Research Site, New York

10065

RECRUITING

Research Site, New York

10210

RECRUITING

Research Site, Bangkok

10300

RECRUITING

Research Site, Dusit

10330

RECRUITING

Research Site, Bangkok

10400

RECRUITING

Research Site, Ratchathewi

NOT_YET_RECRUITING

Research Site, Ratchathewi

10449

RECRUITING

Research Site, Taipei

10469

WITHDRAWN

Research Site, The Bronx

11042

WITHDRAWN

Research Site, New Hyde Park

11220

WITHDRAWN

Research Site, Brooklyn

11501

RECRUITING

Research Site, Mineola

11590

WITHDRAWN

Research Site, Westbury

11790

NOT_YET_RECRUITING

Research Site, Stony Brook

11967

RECRUITING

Research Site, Shirley

13125

RECRUITING

Research Site, Berlin

13273

NOT_YET_RECRUITING

Research Site, Marseille

13620

RECRUITING

Research Site, Seongnam-si

15036

NOT_YET_RECRUITING

Research Site, Lima

15215

RECRUITING

Research Site, Pittsburgh

17033

RECRUITING

Research Site, Hershey

18007

RECRUITING

Research Site, Granada

19104

RECRUITING

Research Site, Philadelphia

20089

RECRUITING

Research Site, Rozzano

20132

RECRUITING

Research Site, Milan

20141

RECRUITING

Research Site, Milan

20357

RECRUITING

Research Site, Hamburg

20902

RECRUITING

Research Site, Silver Spring

20904

RECRUITING

Research Site, Silver Spring

23502

RECRUITING

Research Site, Norfolk

23561

RECRUITING

Research Site, New Taipei City

24105

RECRUITING

Research Site, Kiel

24127

NOT_YET_RECRUITING

Research Site, Bergamo

25030

SUSPENDED

Research Site, Besançon

26506

RECRUITING

Research Site, Morgantown

26831

NOT_YET_RECRUITING

Research Site, Hořovice

28040

RECRUITING

Research Site, Madrid

28041

RECRUITING

Research Site, Madrid

29010

RECRUITING

Research Site, Málaga

29169

WITHDRAWN

Research Site, West Columbia

30625

RECRUITING

Research Site, Hanover

31008

RECRUITING

Research Site, Pamplona

31059

SUSPENDED

Research Site, Toulouse

32224

NOT_YET_RECRUITING

Research Site, Jacksonville

32806

WITHDRAWN

Research Site, Orlando

33021

RECRUITING

Research Site, Hollywood

34214

RECRUITING

Research Site, Istanbul

35128

RECRUITING

Research Site, Padua

37203

RECRUITING

Research Site, Nashville

37404

RECRUITING

Research Site, Chattanooga

38039

RECRUITING

Research Site, Kayseri

40138

RECRUITING

Research Site, Bologna

40207

WITHDRAWN

Research Site, Louisville

40225

RECRUITING

Research Site, Düsseldorf

41013

RECRUITING

Research Site, Seville

41124

WITHDRAWN

Research Site, Modena

41404

RECRUITING

Research Site, Daegu

42300

NOT_YET_RECRUITING

Research Site, Bandar Puncak Alam

44805

NOT_YET_RECRUITING

Research Site, Saint-Herblain

46006

RECRUITING

Research Site, Valencia

46227

WITHDRAWN

Research Site, Indianapolis

48073

WITHDRAWN

Research Site, Royal Oak

NOT_YET_RECRUITING

Research Site, Royal Oak

48126

WITHDRAWN

Research Site, Dearborn

48149

RECRUITING

Research Site, Münster

48202

RECRUITING

Research Site, Detroit

49100

SUSPENDED

Research Site, Angers

NOT_YET_RECRUITING

Research Site, Petah Tikva

50937

WITHDRAWN

Research Site, Cologne

52074

RECRUITING

Research Site, Aachen

52621

NOT_YET_RECRUITING

Research Site, Ramat Gan

53215

WITHDRAWN

Research Site, Milwaukee

54290

RECRUITING

Research Site, Adapazarı

55905

NOT_YET_RECRUITING

Research Site, Rochester

59000

SUSPENDED

Research Site, Lille

59100

NOT_YET_RECRUITING

Research Site, Kuala Lumpur

60068

WITHDRAWN

Research Site, Park Ridge

60190

RECRUITING

Research Site, Winfield

60201

NOT_YET_RECRUITING

Research Site, Evanston

60611

RECRUITING

Research Site, Chicago

61801

RECRUITING

Research Site, Urbana

62250

NOT_YET_RECRUITING

Research Site, Kuala Selangor

64239

RECRUITING

Research Site, Tel Aviv

65804

RECRUITING

Research Site, Springfield

69120

RECRUITING

Research Site, Heidelberg

69373

NOT_YET_RECRUITING

Research Site, Lyon

71640

RECRUITING

Research Site, Ludwigsburg

75000

NOT_YET_RECRUITING

Research Site, Malacca

75005

SUSPENDED

Research Site, Paris

76021

SUSPENDED

Research Site, Rouen

77030

WITHDRAWN

Research Site, Houston

RECRUITING

Research Site, Houston

77054

RECRUITING

Research Site, Houston

77900

NOT_YET_RECRUITING

Research Site, Olomouc

80045

RECRUITING

Research Site, Aurora

80131

RECRUITING

Research Site, Napoli

81100

NOT_YET_RECRUITING

Research Site, Johor Bahru

81501

RECRUITING

Research Site, Grand Junction

81675

RECRUITING

Research Site, München

85234

RECRUITING

Research Site, Gilbert

86150

RECRUITING

Research Site, Augsburg

90089

RECRUITING

Research Site, Los Angeles

90110

RECRUITING

Research Site, Hat Yai

91054

NOT_YET_RECRUITING

Research Site, Erlangen

91206

RECRUITING

Research Site, Glendale

92663

RECRUITING

Research Site, Newport Beach

94805

SUSPENDED

Research Site, Villejuif

98405

RECRUITING

Research Site, Tacoma

100044

RECRUITING

Research Site, Beijing

110016

RECRUITING

Research Site, Shenyang

110029

RECRUITING

Research Site, Delhi

110085

RECRUITING

Research Site, New Delhi

130012

RECRUITING

Research Site, Changchun

130021

RECRUITING

Research Site, Changchun

150081

RECRUITING

Research Site, Harbin

200025

RECRUITING

Research Site, Shanghai

200120

RECRUITING

Research Site, Shanghai

210029

RECRUITING

Research Site, Nanjing

226003

WITHDRAWN

Research Site, Lucknow

230031

RECRUITING

Research Site, Hefei

233004

RECRUITING

Research Site, Bengbu

250117

RECRUITING

Research Site, Shandong

261000

NOT_YET_RECRUITING

Research Site, Weifang

272029

RECRUITING

Research Site, Jining

300000

RECRUITING

Research Site, Tianjin

310016

RECRUITING

Research Site, Hangzhou

310022

RECRUITING

Research Site, Hangzhou

330006

RECRUITING

Research Site, Nanchang

330009

RECRUITING

Research Site, Nanchang

350014

RECRUITING

Research Site, Fuzhou

361003

RECRUITING

Research Site, Xiamen

396007

RECRUITING

Research Site, Surat

400012

NOT_YET_RECRUITING

Research Site, Mumbai

400042

RECRUITING

Research Site, Chongqing

400052

RECRUITING

Research Site, Mumbai

410008

RECRUITING

Research Site, Changsha

410013

RECRUITING

Research Site, Changsha

422002

RECRUITING

Research Site, Nashik

422122

RECRUITING

Research Site, Reggio Emilia

430030

RECRUITING

Research Site, Wuhan

430040

RECRUITING

Research Site, Wuhan

430079

RECRUITING

Research Site, Wuhan

440001

RECRUITING

Research Site, Nagpur

441021

RECRUITING

Research Site, Xiangyang

450008

RECRUITING

Research Site, Zhengzhou

453100

RECRUITING

Research Site, Xinxiang

471000

RECRUITING

Research Site, Luoyang

510060

RECRUITING

Research Site, Guangzhou

510062

RECRUITING

Research Site, Guangzhou

510289

RECRUITING

Research Site, Guangzhou

528000

RECRUITING

Research Site, Foshan

545006

RECRUITING

Research Site, Liuzhou

570017

RECRUITING

Research Site, Mysuru

610000

RECRUITING

Research Site, Chengdu

610072

RECRUITING

Research Site, Chengdu

695011

RECRUITING

Research Site, Thiruvananthapuram

700160

RECRUITING

Research Site, Kolkata

710006

RECRUITING

Research Site, Xi'an

710061

RECRUITING

Research Site, Xi'an

999077

NOT_YET_RECRUITING

Research Site, Hong Kong

2520000

RECRUITING

Research Site, Viña del Mar

3461341

RECRUITING

Research Site, Talca

7500994

RECRUITING

Research Site, Providencia

8330034

RECRUITING

Research Site, Santiago

8420391

RECRUITING

Research Site, Recoleta

9103102

RECRUITING

Research Site, Jerusalem

9112001

RECRUITING

Research Site, Jerusalem

02215

RECRUITING

Research Site, Boston

08103

RECRUITING

Research Site, Camden

08901

WITHDRAWN

Research Site, New Brunswick

C1280AEB

NOT_YET_RECRUITING

Research Site, Ciudad de Buenos Aires

S2000KZE

NOT_YET_RECRUITING

Research Site, Rosario

A4400EMI

RECRUITING

Research Site, Salta

VIC 3000

RECRUITING

Research Site, Melbourne

29308-055

RECRUITING

Research Site, Cachoeira de Itapemirim

80060-900

RECRUITING

Research Site, Curitiba

60336-045

RECRUITING

Research Site, Fortaleza

74000-000

RECRUITING

Research Site, Goiânia

17210-120

RECRUITING

Research Site, Jaú

91350-200

RECRUITING

Research Site, Porto Alegre

14049-901

RECRUITING

Research Site, Ribeirão Preto

41253-190

RECRUITING

Research Site, Salvador

01509-900

RECRUITING

Research Site, São Paulo

03102-002

RECRUITING

Research Site, São Paulo

M5G 2M9

NOT_YET_RECRUITING

Research Site, Toronto

J4V 2G9

NOT_YET_RECRUITING

Research Site, Greenfield Park

H2X 0A9

NOT_YET_RECRUITING

Research Site, Montreal

H3T 1E2

NOT_YET_RECRUITING

Research Site, Montreal

H4A 3J1

NOT_YET_RECRUITING

Research Site, Montreal

S7N 4H4

NOT_YET_RECRUITING

Research Site, Saskatoon

M4N 3M5

NOT_YET_RECRUITING

Research Site, Toronto

010017

WITHDRAWN

Research Site, Hohhot

050000

RECRUITING

Research Site, Shijiazhuang

656 53

NOT_YET_RECRUITING

Research Site, Brno

500 05

NOT_YET_RECRUITING

Research Site, Hradec Králové

120 00

NOT_YET_RECRUITING

Research Site, Prague

180 00

NOT_YET_RECRUITING

Research Site, Prague

06847

RECRUITING

Research Site, Dessau

DE-37099

RECRUITING

Research Site, Göttingen

04103

RECRUITING

Research Site, Leipzig

00168

RECRUITING

Research Site, Rome

260-8717

RECRUITING

Research Site, Chiba

350-1298

RECRUITING

Research Site, Hidaka-shi

573-1191

RECRUITING

Research Site, Hirakata-shi

259-1193

RECRUITING

Research Site, Isehara-shi

892-0833

RECRUITING

Research Site, Kagoshima

227-8577

RECRUITING

Research Site, Kashiwa

135-8550

RECRUITING

Research Site, Kōtoku

860-8556

RECRUITING

Research Site, Kumamoto

606-8507

RECRUITING

Research Site, Kyoto

791-0280

RECRUITING

Research Site, Matsuyama

464-8681

RECRUITING

Research Site, Nagoya

466-8560

RECRUITING

Research Site, Nagoya

467-8602

RECRUITING

Research Site, Nagoya

541-8567

RECRUITING

Research Site, Osaka

373-8550

RECRUITING

Research Site, Ota-shi

003-0804

RECRUITING

Research Site, Sapporo

980-8574

RECRUITING

Research Site, Sendai

142-8666

RECRUITING

Research Site, Shinagawa-ku

565-0871

RECRUITING

Research Site, Suita-shi

411-8777

RECRUITING

Research Site, Sunto-gun

370-0829

RECRUITING

Research Site, Takasaki-shi

514-8507

RECRUITING

Research Site, Tsu

241-8515

RECRUITING

Research Site, Yokohama

CALLAO 2

NOT_YET_RECRUITING

Research Site, Bellavista

LIMA 11

NOT_YET_RECRUITING

Research Site, Jesus Maria, Lima

LIMA 29

NOT_YET_RECRUITING

Research Site, Lima

21-500

WITHDRAWN

Research Site, Biała Podlaska

93-338

RECRUITING

Research Site, Lodz

61-485

RECRUITING

Research Site, Poznan

02-781

RECRUITING

Research Site, Warsaw

3000-075

NOT_YET_RECRUITING

Research Site, Coimbra

1099-023

RECRUITING

Research Site, Lisbon

1998-018

NOT_YET_RECRUITING

Research Site, Lisbon

4454-509

RECRUITING

Research Site, Matosinhos Municipality

4050-115

NOT_YET_RECRUITING

Research Site, Porto

5000-508

NOT_YET_RECRUITING

Research Site, Vila Real

00918

RECRUITING

Research Site, San Juan

02841

RECRUITING

Research Site, Seoul

03080

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

08035

RECRUITING

Research Site, Barcelona

08908

RECRUITING

Research Site, L'Hospitalet de Llobregat

Unknown

RECRUITING

Research Site, Taichung

00333

RECRUITING

Research Site, Taoyuan District

06230

RECRUITING

Research Site, Altındağ-Ankara

06680

WITHDRAWN

Research Site, Çankaya

CB2 2QQ

RECRUITING

Research Site, Cambridge

GU2 7XX

RECRUITING

Research Site, Guildford

SE1 9RT

RECRUITING

Research Site, London

M20 4BX

RECRUITING

Research Site, Manchester

OX3 7LE

WITHDRAWN

Research Site, Oxford

SA2 8QA

SUSPENDED

Research Site, Swansea

TA1 5DA

RECRUITING

Research Site, Taunton

TR1 3LJ

RECRUITING

Research Site, Truro

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY