A Phase III Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis

PHASE3RecruitingINTERVENTIONAL
Enrollment

510

Participants

Timeline

Start Date

November 10, 2023

Primary Completion Date

February 28, 2025

Study Completion Date

April 30, 2026

Conditions
Ankylosing Spondylitis
Interventions
DRUG

AK111

Drug: AK111 subcutaneous injection at week 0,1, 4 and 4-weekly thereafter until week 48.

DRUG

Placebo+AK111

Placebo+AK111 placebo subcutaneous injection at week 0,1, 4,8 and 12 follow AK111 4-weekly thereafter until week 48.

Trial Locations (54)

Unknown

RECRUITING

1006-The First Affiliated Hospital of Bengbu Medical University, Bengbu

RECRUITING

1038-Anhui Provincial Hospital, Hefei

RECRUITING

1001-Peking University Third Hospital, Beijing

RECRUITING

1002-Xuanwu Hospital Capital Medical University, Beijing

RECRUITING

1042-Peking University Shougang Hospital, Beijing

RECRUITING

1049-The First Affiliated Hospital of Xiamen University, Xiamen

RECRUITING

1027-Lanzhou University Second Hospital, Lanzhou

RECRUITING

1005-Nanfang Hospital, Guangzhou

RECRUITING

1025-Guangzhou First People's Hospital, Guangzhou

RECRUITING

1030-Jieyang People's Hospital, Jieyang

RECRUITING

1008-The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen

RECRUITING

1026-Shenzhen People's Hospital, Shenzhen

RECRUITING

1056-Zhongshan Traditional Chinese Medicine Hospital, Zhongshan

RECRUITING

1024-Liuzhou People's Hospital, Liuzhou

RECRUITING

1021-The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning

RECRUITING

1022-The First Affiliated Hospital of Hainan Medical University, Haikou

RECRUITING

1034-Affiliated Hospital of Hebei University, Baoding

RECRUITING

1012-Hebei Petro China Central Hospital, Langfang

RECRUITING

1029-Hebei General Hospital, Shijiazhuang

RECRUITING

1033-The First Hospital of Qiqihar, Qiqihar

RECRUITING

1045-The First Affiliated Hospital of Henan University of Science and Technology, Luoyang

RECRUITING

1053-Nanyang Central Hospital, Nanyang

RECRUITING

1051-Shiyan People's Hospital, Shiyan

RECRUITING

1031-The First Affiliated Hospital of University of South China, Hengyang

RECRUITING

1032-Yueyang Central Hospital, Yueyang

RECRUITING

1011-Zhuzhou Central Hospital, Zhuzhou

RECRUITING

1017-Changzhou NO.2 People's Hospital, Changzhou

RECRUITING

1037-The Second People's Hospital of Lianyungang, Lianyungang

RECRUITING

1004-Zhongda Hospital Southeast University, Nanjing

RECRUITING

1007-Nanjing Drum Tower Hospital, Nanjing

RECRUITING

1036-Jiangsu Province Hospital, Nanjing

RECRUITING

1018-Affiliated Hospital of Nantong University, Nantong

RECRUITING

1035-Wuxi People's Hospital, Wuxi

RECRUITING

1013-Xuzhou Central Hospital, Xuzhou

RECRUITING

1014-Affiliated Hospital of Jiangsu University, Zhenjiang

RECRUITING

1047-The First Affiliated Hospital of Gannan Medical College, Ganzhou

RECRUITING

1020-The Second Affiliated Hospital of Nanchang University, Nanchang

RECRUITING

1039-The First Affiliated Hospital of Nanchang University, Nanchang

RECRUITING

1046-Pingxiang People's Hospital, Pingxiang

RECRUITING

1044-Jilin Provincial People's Hospital, Changchun

RECRUITING

1028- Jining First People's Hospital, Jining

RECRUITING

1019-Linyi City People Hospital, Linyi

RECRUITING

1055-Weifang People's Hospital, Weifang

RECRUITING

1016-Zaozhuang Municipal Hospital, Zaozhuang

RECRUITING

1054-Linfen Central Hospital, Linfen

RECRUITING

1009-Second Hospital of Shanxi Medical University, Taiyuan

RECRUITING

1043-Yuncheng Central Hospital, Yuncheng

RECRUITING

1010-West China Hospital,Sichuan University, Chengdu

RECRUITING

1048-Mianyang Central Hospital, Mianyang

RECRUITING

1041-Affiliated Hospital of North Sichuan Medical College, Nanchong

RECRUITING

1023-The People's Hospital of Xinjiang Uyghur Autonomous Region, Ürümqi

RECRUITING

1040- Huzhou Third People's Hospital, Huzhou

RECRUITING

1015-Taizhou Hospital of Zhejiang Province, Taizhou

RECRUITING

1050-The First Affiliated Hospital of Wenzhou Medical University, Wenzhou

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Akeso

INDUSTRY

NCT06378697 - A Phase III Study to Evaluate the Efficacy and Safety of AK111 in Subjects With Active Ankylosing Spondylitis | Biotech Hunter | Biotech Hunter