A Study of LVGN6051 Combination Therapy in Patient With Head and Neck Squamous Cell Carcinoma (HNSCC)

PHASE2RecruitingINTERVENTIONAL
Enrollment

64

Participants

Timeline

Start Date

June 21, 2024

Primary Completion Date

October 31, 2027

Study Completion Date

October 31, 2027

Conditions
Head and Neck Squamous Cell Carcinoma
Interventions
BIOLOGICAL

LVGN6051 Monoclonal Antibody Injection

LVGN6051 Monoclonal Antibody Injection:1 mg/kg or 2 mg/kg, every 3 weeks(Q3W) , on the first day of the treatment cycle for up to 2 years.

BIOLOGICAL

toripalimab Injection

toripalimab Injection: 240mg fixed dose,Q3W, on the first day of the treatment cycle for up to 2 years.

DRUG

Paclitaxel injection

paclitaxel Injection:5ml:100 mg/m2(80 mg/m2 or 60 mg/m2 can be used if necessary),Q3W,on the first and eighth day of the treatment cycle for up to 2 years

Trial Locations (17)

100142

NOT_YET_RECRUITING

Beijing Cancer Hospital, Beijing

100730

NOT_YET_RECRUITING

Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing

110042

NOT_YET_RECRUITING

Liaoning cancer hospital, Shenyang

200123

RECRUITING

Shanghai Oriental Hospital, Shanghai

230000

NOT_YET_RECRUITING

Anhui Cancer Hospital, Hefei

310022

NOT_YET_RECRUITING

Zhejiang Cancer Hospital, Hangzhou

350014

NOT_YET_RECRUITING

Fujian cancer hospital, Fuzhou

410008

NOT_YET_RECRUITING

Xiangya Hospital Central South University, Changsha

410011

NOT_YET_RECRUITING

The Second Xiangya Hospital, Central South University, Changsha

410031

NOT_YET_RECRUITING

Hunan Cancer Hospital, Changsha

NOT_YET_RECRUITING

Hunan Cancer Hospital, Changsha

430000

NOT_YET_RECRUITING

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430030

NOT_YET_RECRUITING

Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

450008

NOT_YET_RECRUITING

Henan cancer hospital, Zhengzhou

510120

NOT_YET_RECRUITING

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou

530021

RECRUITING

Guangxi Medical University Cancer Hospital, Nanning

610041

RECRUITING

West China Hospital of Sichuan University, Chengdu

All Listed Sponsors
lead

Lyvgen Biopharma Holdings Limited

INDUSTRY