A Study of Lower Radiotherapy Dose to Treat Children With CNS Germinoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

240

Participants

Timeline

Start Date

October 22, 2024

Primary Completion Date

November 4, 2033

Study Completion Date

November 4, 2033

Conditions
Basal Ganglia GerminomaCentral Nervous System GerminomaDiabetes InsipidusPineal Region GerminomaSuprasellar GerminomaThalamic Germinoma
Interventions
RADIATION

3-Dimensional Conformal Radiation Therapy

Undergo 3D-CRT

PROCEDURE

Biospecimen Collection

Undergo blood and CSF sample collection

DRUG

Carboplatin

Given IV

DRUG

Etoposide

Given IV

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

PROCEDURE

Lumbar Puncture

Undergo LP

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Questionnaire Administration

Ancillary studies

PROCEDURE

Surgical Procedure

Undergo second-look surgery

Trial Locations (93)

2031

RECRUITING

Sydney Children's Hospital, Randwick

2145

RECRUITING

The Children's Hospital at Westmead, Westmead

2310

RECRUITING

John Hunter Children's Hospital, Hunter Regional Mail Centre

3052

RECRUITING

Royal Children's Hospital, Parkville

4101

RECRUITING

Queensland Children's Hospital, South Brisbane

10016

RECRUITING

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

10029

RECRUITING

Mount Sinai Hospital, New York

10032

RECRUITING

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

10467

RECRUITING

Montefiore Medical Center - Moses Campus, The Bronx

12208

RECRUITING

Albany Medical Center, Albany

13210

RECRUITING

State University of New York Upstate Medical University, Syracuse

15224

RECRUITING

Children's Hospital of Pittsburgh of UPMC, Pittsburgh

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

19134

RECRUITING

Saint Christopher's Hospital for Children, Philadelphia

19803

RECRUITING

Alfred I duPont Hospital for Children, Wilmington

20010

RECRUITING

Children's National Medical Center, Washington D.C.

21287

RECRUITING

Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore

22908

RECRUITING

University of Virginia Cancer Center, Charlottesville

23507

RECRUITING

Children's Hospital of The King's Daughters, Norfolk

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

27599

RECRUITING

UNC Lineberger Comprehensive Cancer Center, Chapel Hill

29203

RECRUITING

Prisma Health Richland Hospital, Columbia

30329

RECRUITING

Children's Healthcare of Atlanta - Arthur M Blank Hospital, Atlanta

32207

RECRUITING

Nemours Children's Clinic-Jacksonville, Jacksonville

32504

RECRUITING

Nemours Children's Clinic - Pensacola, Pensacola

SUSPENDED

Sacred Heart Hospital, Pensacola

32806

RECRUITING

Arnold Palmer Hospital for Children, Orlando

32827

RECRUITING

Nemours Children's Hospital, Orlando

33021

RECRUITING

Memorial Regional Hospital/Joe DiMaggio Children's Hospital, Hollywood

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33155

RECRUITING

Nicklaus Children's Hospital, Miami

33701

RECRUITING

Johns Hopkins All Children's Hospital, St. Petersburg

36604

RECRUITING

USA Health Strada Patient Care Center, Mobile

38105

RECRUITING

Saint Jude Children's Research Hospital, Memphis

39216

RECRUITING

University of Mississippi Medical Center, Jackson

40202

RECRUITING

Norton Children's Hospital, Louisville

43205

RECRUITING

Nationwide Children's Hospital, Columbus

44106

RECRUITING

Rainbow Babies and Childrens Hospital, Cleveland

48109

RECRUITING

C S Mott Children's Hospital, Ann Arbor

49503

RECRUITING

Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids

52242

RECRUITING

University of Iowa/Holden Comprehensive Cancer Center, Iowa City

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

55455

RECRUITING

University of Minnesota/Masonic Cancer Center, Minneapolis

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

58122

RECRUITING

Sanford Broadway Medical Center, Fargo

60153

RECRUITING

Loyola University Medical Center, Maywood

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

63104

RECRUITING

Cardinal Glennon Children's Medical Center, St Louis

63110

RECRUITING

Washington University School of Medicine, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

68114

RECRUITING

Children's Hospital and Medical Center of Omaha, Omaha

68198

RECRUITING

University of Nebraska Medical Center, Omaha

75230

RECRUITING

Medical City Dallas Hospital, Dallas

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

RECRUITING

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston

RECRUITING

M D Anderson Cancer Center, Houston

78207

RECRUITING

Children's Hospital of San Antonio, San Antonio

78229

RECRUITING

University of Texas Health Science Center at San Antonio, San Antonio

78411

RECRUITING

Driscoll Children's Hospital, Corpus Christi

78723

RECRUITING

Dell Children's Medical Center of Central Texas, Austin

80045

RECRUITING

Children's Hospital Colorado, Aurora

83712

RECRUITING

Saint Luke's Cancer Institute - Boise, Boise

84113

RECRUITING

Primary Children's Hospital, Salt Lake City

85016

RECRUITING

Phoenix Childrens Hospital, Phoenix

90027

RECRUITING

Children's Hospital Los Angeles, Los Angeles

92123

RECRUITING

Rady Children's Hospital - San Diego, San Diego

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

92868

RECRUITING

Children's Hospital of Orange County, Orange

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

94304

RECRUITING

Lucile Packard Children's Hospital Stanford University, Palo Alto

94609

RECRUITING

UCSF Benioff Children's Hospital Oakland, Oakland

97239

RECRUITING

Oregon Health and Science University, Portland

98105

RECRUITING

Seattle Children's Hospital, Seattle

99204

RECRUITING

Providence Sacred Heart Medical Center and Children's Hospital, Spokane

72202-3591

RECRUITING

Arkansas Children's Hospital, Little Rock

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

03756

RECRUITING

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center, Lebanon

07601

RECRUITING

Hackensack University Medical Center, Hackensack

08903

RECRUITING

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital, New Brunswick

07112

RECRUITING

Newark Beth Israel Medical Center, Newark

07503

RECRUITING

Saint Joseph's Regional Medical Center, Paterson

02903

RECRUITING

Rhode Island Hospital, Providence

57117-5134

RECRUITING

Sanford USD Medical Center - Sioux Falls, Sioux Falls

T6G 2B7

RECRUITING

University of Alberta Hospital, Edmonton

B3K 6R8

RECRUITING

IWK Health Centre, Halifax

L8N 3Z5

RECRUITING

McMaster Children's Hospital at Hamilton Health Sciences, Hamilton

N6A 5W9

RECRUITING

Children's Hospital, London

M5G 1X8

RECRUITING

Hospital for Sick Children, Toronto

H3H 1P3

RECRUITING

The Montreal Children's Hospital of the MUHC, Montreal

H3T 1C5

RECRUITING

Centre Hospitalier Universitaire Sainte-Justine, Montreal

J1H 5N4

RECRUITING

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke

G1V 4G2

RECRUITING

CHU de Quebec-Centre Hospitalier de l'Universite Laval (CHUL), Québec

All Listed Sponsors
lead

Children's Oncology Group

NETWORK