Comparison of Two Antibiotic Regimens for the Treatment of Early Airways Infection With PA in Adults With Bronchiectasis

PHASE2RecruitingINTERVENTIONAL
Enrollment

196

Participants

Timeline

Start Date

September 15, 2024

Primary Completion Date

March 15, 2025

Study Completion Date

September 15, 2028

Conditions
Bronchiectasis
Interventions
DRUG

Antibiotic monotherapy treatment and follow-up

"1. a 3-months treatment period, including:~ * an initial phase of 14 days, combining an oral fluoroquinolone (ciprofloxacin 750mg tw/d) with nebulized sodium colistimethate (1 Million Units tw/d)~ * a maintenance phase of 2.5 months: nebulized sodium colistimethate (1 MU tw/d) ;~2. a subsequent follow-up period of 9 months (i.e. until 12 months after the start of antibiotic therapy against Pseudomonas aeruginosa)."

DRUG

Antibiotic bitherapy treatment and follow-up

"1. a 3-months treatment period, including:~ * an initial phase of 14 days, combining an IV beta-lactam antibitic (ceftazidime 4 or 6g/d) and an oral fluoroquinolone (ciprofloxacin 750mg tw/d) with nebulized sodium colistimethate (1 Million Units tw/d)~ * a maintenance phase of 2.5 months: nebulized sodium colistimethate (1 MU tw/d) ;~2. a subsequent follow-up period of 9 months (i.e. until 12 months after the start of antibiotic therapy against Pseudomonas aeruginosa)."

Trial Locations (18)

13008

RECRUITING

Clinique St Joseph, Marseille

75013

RECRUITING

Hôpital Pitié Salpêtrière, Paris

94010

RECRUITING

Centre hospitalier intercommunal de Créteil, Créteil

Unknown

RECRUITING

CHU Amiens-Picardie, Amiens

RECRUITING

CHU Haut Leveque, Bordeaux, Bordeaux

RECRUITING

CHRU Brest, Brest

RECRUITING

CH Pontoise, Cergy-Pontoise

RECRUITING

APHP, Henri Mondor, Créteil

NOT_YET_RECRUITING

Hôpital de la Croix Rousse, HCL, Lyon, Lyon

RECRUITING

CHU Nantes, Nantes

NOT_YET_RECRUITING

CHU H. Pasteur, Nice, Nice

RECRUITING

APHP, Cochin, Paris

RECRUITING

APHP, Saint Louis, Paris

RECRUITING

APHP, Tenon, Paris

RECRUITING

Hôpital Foch, Suresnes, Suresnes

RECRUITING

CHU H. Larrey, Toulouse, Toulouse

RECRUITING

CH Versailles, Versailles

RECRUITING

CH Villefranche s/Saône, Villefranche-sur-Saône

All Listed Sponsors
collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

lead

Centre Hospitalier Intercommunal Creteil

OTHER