A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression

PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

July 29, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2027

Conditions
Recurrent Ovarian CancerFolate Receptor-Alpha Positive
Interventions
DRUG

Mirvetuximab Soravtansine

Mirvetuximab soravtansine is an antibody drug conjugate designed to target folate receptor α (FRα). It consists of the humanized anti-FRα monoclonal antibody (mAb) M9346A attached via a cleavable disulfide linker to the cytotoxic maytansinoid, DM4.

DRUG

Lubricating Eye Drops

Lubricating artificial tears should be administered at least 15 minutes after corticosteroid or brimonidine eye drop administration.

DRUG

Prednisolone acetate ophthalmic suspension 1% eye drops

Self-administration of prednisolone acetate ophthalmic suspension 1% eye drops as prescribed by the treating physician.

DRUG

Brimonidine tartrate ophthalmic solution eye drops

Self-administration of brimonidine tartrate ophthalmic solution eye drops as prescribed by the treating physician.

Trial Locations (40)

2148

ACTIVE_NOT_RECRUITING

Blacktown Hospital /ID# 269305, Blacktown

2305

ACTIVE_NOT_RECRUITING

Newcastle Private Hosptial /ID# 269306, Lambton Heights

2650

COMPLETED

Universitair Ziekenhuis Antwerpen /ID# 269310, Edegem

3000

ACTIVE_NOT_RECRUITING

UZ Leuven /ID# 269308, Leuven

3168

ACTIVE_NOT_RECRUITING

Monash Health - Monash Medical Centre /ID# 269304, Clayton

4000

COMPLETED

CHU de Liege /ID# 269312, Liège

9000

ACTIVE_NOT_RECRUITING

AZ Sint-Lucas /ID# 269307, Ghent

COMPLETED

UZ Gent /ID# 269309, Ghent

9300

ACTIVE_NOT_RECRUITING

OLV Ziekenhuis Aalst /ID# 269311, Aalst

10003

ACTIVE_NOT_RECRUITING

Hospital San Pedro de Alcántara /ID# 269320, Cáceres

12208

COMPLETED

Women'S Cancer Care Associates /ID# 269980, Albany

13273

ACTIVE_NOT_RECRUITING

Institut Paoli-Calmettes /ID# 269648, Marseille

20910

RECRUITING

Holy Cross Hospital - Silver Spring /ID# 269344, Silver Spring

23007

ACTIVE_NOT_RECRUITING

Hospital Universitario de Jaén /ID# 269319, Jaén

27710

RECRUITING

Duke Cancer Institute /ID# 269342, Durham

28034

ACTIVE_NOT_RECRUITING

Hospital Universitario Ramon y Cajal /ID# 269318, Madrid

28041

ACTIVE_NOT_RECRUITING

Hospital Universitario 12 de Octubre /ID# 269321, Madrid

28046

ACTIVE_NOT_RECRUITING

Hospital Universitario La Paz /ID# 269302, Madrid

37000

ACTIVE_NOT_RECRUITING

Centre Hospitalier Régional Universitaire de Tours - Hôpital Bretonneau /ID# 269301, Tours

40207

COMPLETED

Norton Cancer Institute - St. Matthews /ID# 269070, Louisville

46026

COMPLETED

Hospital Universitario y Politecnico La Fe /ID# 269325, Valencia

63141

RECRUITING

Mercy David C. Pratt Cancer Center /ID# 269350, St Louis

69310

ACTIVE_NOT_RECRUITING

Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 269327, Pierre-Bénite

72000

ACTIVE_NOT_RECRUITING

Clinique Victor Hugo Le Mans /ID# 269985, Le Mans

75020

ACTIVE_NOT_RECRUITING

GH Diaconesses Croix Saint-Simon /ID# 269329, Paris

75390

RECRUITING

UT Southwestern Medical Center /ID# 269341, Dallas

75679

ACTIVE_NOT_RECRUITING

Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 269330, Paris

77089

RECRUITING

Memorial Hermann Southeast Hospital /ID# 269347, Houston

89511

ACTIVE_NOT_RECRUITING

The Center Of Hope /ID# 269348, Reno

90095

RECRUITING

University of California Los Angeles /ID# 269339, Los Angeles

07666

RECRUITING

Holy Name Medical Center /ID# 269340, Teaneck

12206-5013

COMPLETED

New York Oncology Hematology - Albany Cancer Center /ID# 269345, Albany

44304-1407

RECRUITING

Summa Health /ID# 269349, Akron

H1T 2M4

ACTIVE_NOT_RECRUITING

Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 268862, Montreal

H2X 3E4

ACTIVE_NOT_RECRUITING

Centre Hospitalier De L'Universite De Montreal - Hopital Saint-Luc /ID# 269314, Montreal

H4A 3J1

ACTIVE_NOT_RECRUITING

McGill University Health Centre - Glen Site /ID# 269313, Montreal

D07 R2WY

ACTIVE_NOT_RECRUITING

Mater Misericordiae University Hospital /ID# 269334, Dublin

D09 XR63

COMPLETED

Beaumont Hospital /ID# 268864, Dublin

08028

ACTIVE_NOT_RECRUITING

Usp Instituto Universitario Dexeus /ID# 269322, Barcelona

08035

ACTIVE_NOT_RECRUITING

Hospital Universitario Vall de Hebron /ID# 269315, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY