1,250
Participants
Start Date
April 12, 2024
Primary Completion Date
May 5, 2032
Study Completion Date
May 5, 2032
Nivolumab
Briefly, nivolumab is administered as an approximately 30-minute (240mg every 2 weeks) or 60-minute (480mg every 4 weeks) IV infusion. Nivolumab is to be administered first. The nivolumab infusion must be promptly followed by a saline flush to clear the line of nivolumab before starting the ipilimumab infusion.
Ipilimumab
"The second infusion will always be ipilimumab and will start at least 30 minutes after completion of the nivolumab infusion. Ipilimumab is to be administered as an approximately 30-minute IV infusion.~When administered together, nivolumab and ipilimumab will be administered on Day 1 of each 21-day cycle."
Pembrolizumab
Pembrolizumab is to be administered as an approximately 30-minute IV infusion.
Cabozantinib
Cabozantinib is a medication that is taken orally every day, once a day away from meals at the initial dose of 40 mg/day.
Axitinib
Axitinib is a medication that is taken orally every day, 2 times a day continuously, at the starting dose of 5mg x2/day.
Lenvatinib
Lenvatinib is a medication that is taken orally every day, once a day at the initial dose of 20mg/day.
NOT_YET_RECRUITING
Medical University of Vienna, Vienna
RECRUITING
Institut Paoli-Calmettes, Marseille
RECRUITING
Centre François Baclesse, Caen
NOT_YET_RECRUITING
Fakultní nemocnice v Motole, University Hospital Motol (MOTOL), Prague
RECRUITING
Centre Georges-François Leclerc, Dijon
RECRUITING
Hôpital Jean Minjoz, Besançon
RECRUITING
CHU de Nîmes, Nîmes
RECRUITING
Oncopole Claudius Regaud - IUCT-Oncopole, Toulouse
NOT_YET_RECRUITING
CHU de Bordeaux Hôpital Saint-André, Bordeaux
RECRUITING
Institut Régional du Cancer de Montpellier, Montpellier
RECRUITING
Centre Eugène Marquis, Rennes
RECRUITING
Hôpital Bretonneau, Tours
RECRUITING
CHU Grenoble, Grenoble
NOT_YET_RECRUITING
CHU Saint-Etienne, Saint-Etienne
RECRUITING
Institut de Cancérologie de l'Ouest - Saint Herblain, Saint-Herblain
RECRUITING
Institut de Cancérologie de l'Ouest - Angers, Angers
RECRUITING
CHU Angers, Angers
NOT_YET_RECRUITING
Fakultní nemocnice Hradec Králová, University Hospital Hradec Kralove (FNHK), Hradec Králové
RECRUITING
Institut Godinot, Reims
RECRUITING
Institut de Cancérologie de Lorraine, Vandœuvre-lès-Nancy
NOT_YET_RECRUITING
Centre Oscar Lambret, Lille
NOT_YET_RECRUITING
Centre Jean Perrin, Clermont-Ferrand
RECRUITING
CH de Pau, Pau
RECRUITING
CH de la Côte Basque, Bayonne
NOT_YET_RECRUITING
Masarykův onkologický ústav, Masaryk Memorial Cancer Institute (MOU), Brno
RECRUITING
Institut de cancérologie Strasbourg Europe, Strasbourg
NOT_YET_RECRUITING
Centre Léon Bérard, Lyon
RECRUITING
Hospices Civils de Lyon, Pierre-Bénite
NOT_YET_RECRUITING
CH Châlon Sur Saône, Chalon-sur-Saône
NOT_YET_RECRUITING
Hôpital de la Pitié Salpêtrière, Paris
NOT_YET_RECRUITING
Hôpital Bichat - Claude Bernard, Paris
RECRUITING
Hôpital Tenon, Paris
RECRUITING
Hôpital Saint-Louis, Paris
RECRUITING
Institut Mutualiste Montsouris, Paris
RECRUITING
Fakultní nemocnice Olomouc, University Hospital Olomouc (FNOL), Olomouc
RECRUITING
Institut Sainte Catherine, Avignon
RECRUITING
CHD Vendée, La Roche-sur-Yon
RECRUITING
CHU Poitiers, Poitiers
RECRUITING
Polyclinique de Limoges, Limoges
RECRUITING
Hôpital Foch, Suresnes
RECRUITING
Hôpital Henri Mondor, Créteil
RECRUITING
HIA Bégin, Saint-Mandé
RECRUITING
Gustave Roussy, Villejuif
RECRUITING
CHU Sud Réunion, Saint-Pierre
RECRUITING
Centre Antoine Lacassagne, Nice
NOT_YET_RECRUITING
Antoni van Leeuwenhoek, Amsterdam
Collaborators (1)
European Commission
OTHER
CRIS Cancer Foundation
UNKNOWN
National Cancer Institute, France
OTHER_GOV
Rennes University Hospital
OTHER
University Hospital, Essen
OTHER
Fundació Privada Institut d'Investigació Oncològica de Vall d'Hebron
UNKNOWN
The Netherlands Cancer Institute
OTHER
Servicio Madrileño de Salud, Madrid, Spain
OTHER
Hospital Universitario 12 de Octubre
OTHER
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
OTHER
Medical University of Vienna
OTHER
FAKULTNI NEMOCNICE OLOMOUC
UNKNOWN
International Kidney Cancer Coalition
UNKNOWN
Association pour la Recherche sur les Tumeurs du Rein
UNKNOWN
Resilience
INDUSTRY
PRIMAA
UNKNOWN
Queen Mary University of London
OTHER
Gustave Roussy, Cancer Campus, Grand Paris
OTHER