Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

PHASE3RecruitingINTERVENTIONAL
Enrollment

1,100

Participants

Timeline

Start Date

June 3, 2024

Primary Completion Date

October 31, 2025

Study Completion Date

November 30, 2025

Conditions
Surgical Site Infection
Interventions
DRUG

Povidone-Iodine

"Peritoneal lavage: With the fascia open, the peritoneum will be washed out with 1L of dilute aqueous povidone-iodine solution allowing the solution to sit in the peritoneum for 2 minutes. This is followed by suctioning of the povidone-iodine solution then wash-out with 2L of normal saline followed by suctioning of the normal saline.~Wound Irrigation: With the fascia closed, the wound will be irrigated with 500mL povidone-iodine solution, suctioned, then washed-out with 500 mL normal saline."

DRUG

Normal Saline

"Peritoneal lavage: With the fascia open, the peritoneum will be washed out with 1L of normal saline allowing the solution to sit in the peritoneum for 2 minutes. This is followed by suctioning of the solution, wash-out with 2L of normal saline, followed by suctioning of the normal saline.~Wound Irrigation: With the fascia closed, the wound will be irrigated with 500mL normal saline solution, suctioned, then washed-out with 500 mL normal saline."

Trial Locations (1)

92354

RECRUITING

Loma Linda University Health, Loma Linda

All Listed Sponsors
lead

Loma Linda University

OTHER