Methylprednisolone Adjunctive to Endovascular Thrombectomy for Stroke

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

928

Participants

Timeline

Start Date

August 1, 2024

Primary Completion Date

October 31, 2025

Study Completion Date

June 30, 2030

Conditions
Acute Ischemic Stroke
Interventions
DRUG

Methylprednisolone sodium succinate

Intravenous injection of methylprednisolone sodium succinate (Chongqing Lummy Pharmaceutical Co., Ltd., 40mg/bottle) with a dose of 2mg/kg (maximum dose of 160mg), once daily, for three consecutive days. The initial study drug will be administered as soon as possible after randomization. It is recommended that the initial study drug administrated before arterial access closure, but it should not be delayed more than 2 hours after arterial access closure.

DRUG

Placebo (normal saline)

Intravenous injection of placebo (normal saline) (Chongqing Lummy Pharmaceutical Co., Ltd., 40mg/bottle) with a dose of 2mg/kg (maximum dose of 160mg), once daily, for three consecutive days. The initial study drug will be administered as soon as possible after randomization. It is recommended that the initial study drug administrated before arterial access closure, but it should not be delayed more than 2 hours after arterial access closure.

Trial Locations (99)

14040

Baotou Central Hospital, Baotou

30001

Cardiovascular Hospita affected to Shanxi Medical University, Taiyuan

30012

Shanxi Provincial People's Hospital, Taiyuan

200025

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

221002

The Affiliated Hospital of Xuzhuo Medical University, Xuzhou

230001

The First Affiliated Hospital of USTC, Hefei

230061

Hefei First People's Hospital, Hefei

236600

Taihe County People's Hospital, Taihe Chengguanzhen

241001

Yijishan Hospital of Wannan Medical College, Wuhu

250011

Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan

250013

Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan

252000

Liaocheng People's Hospital, Liaocheng

Liaocheng third people's hospital, Liaocheng

266003

The affiliated Hospital of Qingdao Univercity, Qingdao

271000

The Second Affiliated Hospital of Shandong First Medical University, Tai’an

273500

Zoucheng People's Hospital, Shandong Province, Zoucheng

300350

Tianjin Huanhu Hospital, Tianjin

330006

Jiangxi Provincial People's Hospital, Nanchang

The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang

332000

Jiujiang University Affiliated Hospital, Jiujiang

The First People's Hospital of jiujiang, Jiujiang

333000

Jingdezhen First People's Hospital, Jingdezhen

335000

YingTan people's hospital, Yingtan

341000

First Affiliated Hospital of Gannan Medical University, Ganzhou

Ganzhou People's Hospital, Ganzhou (G.Z.), Ganzhou

350001

Fuzhou University Affiliated Provincial Hospital, Fuzhou

Union Hospital Affiliated to Fujian Medical University, Fuzhou

350003

The Second Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou

350005

Department of Neurology, First Affiliated Hospital Fujian Medical University, Fuzhou

350025

900th Hospital of PLA Joint Logistic Support Force, Fuzhou

350300

Fuqing City Hospital of Fujian, Fuqing

351100

Putian University Affiliated Hospital, Putian

The First Hospital of Putian City, Putian

352100

Mingdong Hospital, Ningde

Ningde Municipal Hospital, Ningde Normal University, Ningde

353000

Nanping First Hospital, Nanping

354000

Shaowu Municiple Hospital, Shaowu

361003

The First Affiliated Hospital of Xiamen University, Xiamen

361004

Zhongshan Hosipital Xiamen University, Xiamen

362000

Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou

The 910th Hospital of the Joint Logistics Support Force of the Chinese PLA, Quanzhou

The Second Affiliated Hospital of Fujian Medical University, Quanzhou

362400

Anxi County Hospital, Anxi

Anxi Hospital of Traditional Chinese Medicine, Anxi

363000

900th Hospital of PLA Joint Logistic Support Force, Zhangzhou

Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou

364000

Longyan First Affiliated Hospital of Fujian Medical University, Longyan

365000

SanMing First Hospital, Sanming

430012

Wuhan Hankou Hospital, Wuhan

430014

The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430022

Wuhan NO.1 hospital, Wuhan

430030

Tongji hospital, Tongji medical college, Huazhong university of science and technology, Wuhan

430033

The Third People's Hospital of Hubei Province, Wuhan

430060

Wuhan University Renmin Hospital, Wuhan

430071

Zhongnan Hospital of Wuhan University, Wuhan

430200

The First people's Hospital of Jiangxia District, Wuhan

431700

The First People's Hospital of Tianmen in Hubei Province, Tianmen

434000

Yangtze University Affiliated Hospital, Jingzhou

434020

Jingzhou Hospital Affiliated to Yangtze University, Jingzhou

435000

Huangshi Central Hospital, Huangshi

435300

Qichun People's Hospital, Huanggang

436000

Ezhou Central Hospital, Ezhou

437100

Xianning Central Hospital, Xianning

438000

Huanggang Central Hospital, Huanggang

441000

Xiangyang Hospital of Traditional Chinese Medicine, Xiangyang

Xiangyang No.1 People's Hospital, Hubei University of Medicine., Xiangyang

442000

Shiyan Hospital of Integrated Traditional and Western Medicine, Shiyan

Shiyan Renmin Hospital, Shiyan

Taihe Hospital Affiliated to Hubei University of Medicine, Shiyan

443000

TheSecondPeople's Hospitalof Yichang, Yichang

445000

The Central Hospital of Enshi Tujia And Miao Automomous Prefecture, Enshi

445400

Lichuan City Ethnic Traditional Chinese Medical Hospital, Lichuan

463000

ZhuMaDian Centeral Hospital, Zhumadian

Zhumadianthefirstpeoplehospital, Zhumadian

463700

Biyangxianrenminyiyuan, Bishui

466000

Zhoukou Centeral Hospital, Zhoukou

466600

Xihua People's Hospital, Wacheng Neighborhood

510120

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou

510180

Guangzhou First People's Hospital, Guangzhou

515031

Shantou Central Hospital, Shantou

524001

Affiliated Hospital of Guangdong Medical University, Zhanjiang

524037

Central people' s hospital of zhanjiang, Zhanjiang

525000

Maoming Hospital of Traditional Chinese Medicine, Maoming

Maoming people's hospital, Maoming

537000

Red Cross Hospital of Yulin City, Yulin

551400

The First People's Hospital of Qingzhen, Qingzhen

570102

The First Affiliated Hospital of Hainan Medical University, Haikou

570311

The Second Affiliated Hospital of Hainan Medical University, Haikou

611230

Chongzhou People's Hospital, Chengdu

621000

Mianyang 404 Hospital, Mianyang

Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang

629000

Suining Central Hospital, Suining

637000

Affiliated Hospital of North Sichuan Medical College, Nanchong

643020

Zigong Third People's Hospital, Zigong

646500

Gulin County People's Hospital, Gulin

655000

QuJing NO.1 hospital, Qujing

712000

The First People's Hospital of Xianyang, Xianyang

730050

Gansu Province Central Hospital, Lanzhou

833400

Bozhou People'S Hospital, Bole

All Listed Sponsors
lead

Wan-Jin Chen

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NCT06360458 - Methylprednisolone Adjunctive to Endovascular Thrombectomy for Stroke | Biotech Hunter | Biotech Hunter