A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103)

PHASE1RecruitingINTERVENTIONAL
Enrollment

350

Participants

Timeline

Start Date

May 29, 2024

Primary Completion Date

February 26, 2027

Study Completion Date

February 25, 2029

Conditions
Advanced Gastrointestinal, Biliary Tract, and Pancreatic Cancers
Interventions
DRUG

AMG 193

Administered Orally

DRUG

Gemcitabine

Administered IV

DRUG

Nab-paclitaxel

Administered IV

DRUG

Modified FOLFIRINOX

Modified FOLFIRINOX consists of irinotecan, 5-FU, LV, and oxaliplatin administered IV

DRUG

RMC-6236

Administered orally

Trial Locations (77)

1200

RECRUITING

Universite Catholique de Louvain Cliniques Universitaires Saint Luc, Brussels

2050

RECRUITING

Chris OBrien Lifehouse, Camperdown

2065

RECRUITING

GenesisCare -North Shore Oncology, St Leonards

2650

RECRUITING

Universitair Ziekenhuis Antwerpen, Edegem

2730

RECRUITING

Herlev og Gentofte Hospital, Herlev

3000

RECRUITING

Peter MacCallum Cancer Centre, Melbourne

RECRUITING

Universitair Ziekenhuis Leuven - Campus Gasthuisberg, Leuven

3021

RECRUITING

Epworth Healthcare, St Albans

3084

RECRUITING

Austin Health, Austin Hospital, Heidelberg

5011

RECRUITING

The Queen Elizabeth Hospital, Woodville South

10002

RECRUITING

National Taiwan University Hospital, Taipei

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

11217

RECRUITING

Taipei Veterans General Hospital, Taipei

11528

RECRUITING

Alexandra Hospital, Athens

13009

RECRUITING

Institut Paoli Calmettes, Marseille

20089

RECRUITING

IRCCS Istituto Clinico Humanitas, Rozzano MI

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

20162

RECRUITING

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan

21000

RECRUITING

Centre Georges Francois Leclerc, Dijon

22031

RECRUITING

Virginia Cancer Specialists PC, Fairfax

22903

RECRUITING

University of Virginia Cancer Center, Charlottesville

27710

RECRUITING

Duke University, Durham

28009

RECRUITING

Hospital General Universitario Gregorio Maranon, Madrid

33000

RECRUITING

Institut Bergonie, Bordeaux

37134

RECRUITING

Centro Ricerche Cliniche Di Verona Societa responsabilita limitata, Verona

37203

RECRUITING

United States Oncology Regulatory Affairs Corporate Office, Nashville

40202

RECRUITING

Norton Cancer Institute, Louisville

41013

RECRUITING

Hospital Universitario Virgen del Rocio, Seville

44195

RECRUITING

Cleveland Clinic Foundation, Cleveland

45147

RECRUITING

Universitaetsklinikum Essen, Essen

46202

RECRUITING

Indiana University, Indianapolis

55236

RECRUITING

Saint Luke Hospital, Thessaloniki

56429

RECRUITING

General Hospital Of Thessaloniki Papageorgiou, Thessaloniki

60637

RECRUITING

University of Chicago, Chicago

63110

RECRUITING

Washington University, St Louis

68198

RECRUITING

University of Nebraska, Omaha

69120

RECRUITING

Universitaetsklinikum Heidelberg, Heidelberg

70403

RECRUITING

National Cheng Kung University Hospital, Tainan City

75063

RECRUITING

US Oncology Research Investigational Products Center, Irving

77030

TERMINATED

Oncology Consultants Cancer Center, Houston

80012

RECRUITING

Rocky Mountain Cancer Centers, Aurora

89169

TERMINATED

Comprehensive Cancer Centers of Nevada, Las Vegas

90095

RECRUITING

Translational Research in Oncology US Inc, Trio Central Pharmacy, Los Angeles

90404

RECRUITING

University of California Los Angeles, Santa Monica

91010

RECRUITING

City of Hope National Medical Center, Duarte

RECRUITING

City of Hope Orange County Lennar Foundation Cancer Center, Duarte

92093

RECRUITING

University of California San Diego Moores Cancer Center, La Jolla

93309

RECRUITING

Comprehensive Blood and Cancer Center, Bakersfield

94805

RECRUITING

Gustave Roussy, Villejuif

97078

RECRUITING

Universitaetsklinikum Wuerzburg, Würzburg

98106

RECRUITING

Fred Hutchinson Cancer Center, Seattle

98405

RECRUITING

Northwest Medical Specialties, PLLC, Tacoma

98684

RECRUITING

Northwest Cancer Specialists - Vancouver, Vancouver

130021

RECRUITING

The First Bethune Hospital of Jilin University, Changchun

150000

RECRUITING

Harbin Medical University Cancer Hospital, Harbin

350028

RECRUITING

Mengchao Hepatobiliary hospital of Fujian Medical University, Fuzhou

430022

RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

450052

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

510030

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

06106

RECRUITING

Hartford Hospital, Hartford

06520

RECRUITING

Yale University, New Haven

06856

RECRUITING

Norwalk Hospital, Norwalk

02215

RECRUITING

Beth Israel Deaconess Medical Center, Boston

RECRUITING

Dana-Farber Cancer Institute, Boston

T2N 5G2

RECRUITING

Arthur J E Child Comprehensive Cancer Centre, Calgary

M5G 1Z5

RECRUITING

Princess Margaret Cancer Centre, Toronto

G1J 1Z4

RECRUITING

CHU de Quebec Hopital de l Enfant Jesus, Québec

Unknown

RECRUITING

Queen Mary Hospital, The University of Hong Kong, Hong Kong

RECRUITING

Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories

464-8681

RECRUITING

Aichi Cancer Center, Nagoya

277-8577

RECRUITING

National Cancer Center Hospital East, Kashiwa-shi

241-8515

RECRUITING

Kanagawa Prefectural Hospital Organization Kanagawa Cancer Center, Yokohama

104-0045

RECRUITING

National Cancer Center Hospital, Chuo-ku

6525 GA

RECRUITING

Radboud Universitair Medisch Centrum, Nijmegen

08035

RECRUITING

Hospital Universitari Vall d Hebron, Barcelona

B15 2TH

RECRUITING

Queen Elizabeth Hospital Birmingham, Birmingham

W1G 6AD

RECRUITING

Sarah Cannon Research Institute UK, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY

NCT06360354 - A Study Evaluating AMG 193 in Combination With Other Therapies in Participants With Advanced Gastrointestinal, Biliary Tract, or Pancreatic Cancers With Homozygous Methylthioadenosine Phosphorylase (MTAP)-Deletion (MTAPESTRY 103) | Biotech Hunter | Biotech Hunter