Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus

NARecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

January 1, 2024

Primary Completion Date

January 1, 2025

Study Completion Date

December 31, 2026

Conditions
Osteochondral Lesion of TalusMicrofracturesPlatelet Rich Plasma
Interventions
PROCEDURE

Arthroscopic microfracture with intraoperative local PRP gel injection

"Arthroscopic microfracture:~An anteromedial portal and an anterolateral portal are routinely established. A diagnostic arthroscopy is performed. Defects of superficial cartilage, cystic components, and necrotic bone are debrided arthroscopically with curette and shaver to a stable circumferential rim. Microfracture awls are introduced and subchondral channels to 4-6 mm in depth are created, spacing the channels 3 to 5 mm apart across the entire surface of the lesion.~PRP preparation and local injection:~PRP is harvested using a PRP preparation kit via centrifugation. Fifty milliliters of autologous venous blood are drawn from the patient and processed. Platelet count is measured for quality control. On average 4 ml of (range 3-6) PRP is obtained and mixed with thrombin calcium agent in preparation for PRP gel. PRP gel is administered to the injured area using a blunt and long-tip injector, with direct visualization under arthroscope."

PROCEDURE

Isolated microfracture

"Arthroscopic microfracture:~An anteromedial portal and an anterolateral portal are routinely established. A diagnostic arthroscopy is performed. Defects of superficial cartilage, cystic components, and necrotic bone are debrided arthroscopically with curette and shaver to a stable circumferential rim. Microfracture awls are introduced and subchondral channels to 4-6 mm in depth are created, spacing the channels 3 to 5 mm apart across the entire surface of the lesion."

Trial Locations (1)

Unknown

RECRUITING

Peking University Third Hospital, Beijing

All Listed Sponsors
lead

Peking University Third Hospital

OTHER