Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

PHASE3RecruitingINTERVENTIONAL
Enrollment

675

Participants

Timeline

Start Date

April 11, 2024

Primary Completion Date

April 24, 2028

Study Completion Date

May 24, 2030

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Datopotamab Deruxtecan

Datopotamab Deruxtecan IV (intravenous)

DRUG

Rilvegostomig

Rilvegostomig IV (intravenous)

DRUG

Pembrolizumab

Pembrolizumab IV (intravenous)

Trial Locations (269)

112

RECRUITING

Research Site, Taipei

220

RECRUITING

Research Site, New Taipei City

333

RECRUITING

Research Site, Taoyuan District

704

RECRUITING

Research Site, Tainan City

1070

WITHDRAWN

Research Site, Anderlecht

1121

RECRUITING

Research Site, Budapest

1140

RECRUITING

Research Site, Vienna

1210

RECRUITING

Research Site, Vienna

2045

RECRUITING

Research Site, Törökbálint

2148

RECRUITING

Research Site, Blacktown

2250

RECRUITING

Research Site, Gosford

3000

WITHDRAWN

Research Site, Melbourne

3100

RECRUITING

Research Site, Salgótarján

3168

RECRUITING

Research Site, Clayton

3200

WITHDRAWN

Research Site, Gyöngyös

NOT_YET_RECRUITING

Research Site, Gyöngyös - Mátraháza

3500

RECRUITING

Research Site, Krems

RECRUITING

Research Site, Hasselt

3690

RECRUITING

Research Site, Wodonga

4000

RECRUITING

Research Site, Liège

4020

RECRUITING

Research Site, Linz

4215

WITHDRAWN

Research Site, Southport

4575

RECRUITING

Research Site, Birtinya

4600

RECRUITING

Research Site, Wels

5700

NOT_YET_RECRUITING

Research Site, Gyula

6000

RECRUITING

Research Site, Kecskemét

6020

RECRUITING

Research Site, Innsbruck

6200

RECRUITING

Research Site, Ankara

6830

RECRUITING

Research Site, Rankweil

7100

RECRUITING

Research Site, La Louvière

NOT_YET_RECRUITING

Research Site, Szekszárd

8000

NOT_YET_RECRUITING

Research Site, Székesfehérvár

9024

RECRUITING

Research Site, Győr

10002

RECRUITING

Research Site, Taipei

10249

NOT_YET_RECRUITING

Research Site, Berlin

10400

NOT_YET_RECRUITING

Research Site, Bangkok

11029

RECRUITING

Research Site, New Delhi

11407

RECRUITING

Research Site, Jerez de la Frontera

11794

RECRUITING

Research Site, Stony Brook

13496

RECRUITING

Research Site, Seongnam-si

14467

NOT_YET_RECRUITING

Research Site, Potsdam

16132

RECRUITING

Research Site, Genoa

16247

RECRUITING

Research Site, Suwon

16499

RECRUITING

Research Site, Suwon

20000

NOT_YET_RECRUITING

Research Site, Mueang

20052

NOT_YET_RECRUITING

Research Site, Monza

20089

RECRUITING

Research Site, Rozzano

20141

RECRUITING

Research Site, Milan

20162

RECRUITING

Research Site, Milan

20176

RECRUITING

Research Site, Leesburg

20251

RECRUITING

Research Site, Hamburg

21280

RECRUITING

Research Site, Diyarbakır

21401

RECRUITING

Research Site, Annapolis

21565

RECRUITING

Research Site, Incheon

22000

NOT_YET_RECRUITING

Research Site, Muang

22060

NOT_YET_RECRUITING

Research Site, Fort Belvoir

22087

RECRUITING

Research Site, Hamburg

23230

RECRUITING

Research Site, Richmond

24125

RECRUITING

Research Site, Bergamo

27100

RECRUITING

Research Site, Pavia

27834

NOT_YET_RECRUITING

Research Site, Greenville

28144

NOT_YET_RECRUITING

Research Site, Salisbury

29607

RECRUITING

Research Site, Greenville

30303

SUSPENDED

Research Site, Atlanta

30318

RECRUITING

Research Site, Atlanta

30322

RECRUITING

Research Site, Atlanta

30342

WITHDRAWN

Research Site, Atlanta

32000

NOT_YET_RECRUITING

Research Site, Mueang

32608

RECRUITING

Research Site, Gainesville

32763

RECRUITING

Research Site, Orange City

32806

NOT_YET_RECRUITING

Research Site, Orlando

32827

WITHDRAWN

Research Site, Orlando

33140

RECRUITING

Research Site, Miami Beach

33332

RECRUITING

Research Site, Gütersloh

33401

RECRUITING

Research Site, West Palm Beach

34030

RECRUITING

Research Site, Istanbul

34711

RECRUITING

Research Site, Clermont

34890

RECRUITING

Research Site, Istanbul

35128

RECRUITING

Research Site, Padua

37007

RECRUITING

Research Site, Salamanca

37404

WITHDRAWN

Research Site, Chattanooga

37920

WITHDRAWN

Research Site, Knoxville

39401

RECRUITING

Research Site, Hattiesburg

40447

RECRUITING

Research Site, Taichung

40489

WITHDRAWN

Research Site, Düsseldorf

43204

RECRUITING

Research Site, Reus,Tarragona

43210

WITHDRAWN

Research Site, Columbus

43608

NOT_YET_RECRUITING

Research Site, Toledo

45136

NOT_YET_RECRUITING

Research Site, Essen

45219

RECRUITING

Research Site, Cincinnati

46062

RECRUITING

Research Site, Noblesville

48100

RECRUITING

Research Site, Ravenna

48126

RECRUITING

Research Site, Dearborn

48334

RECRUITING

Research Site, Farmington Hills

49124

RECRUITING

Research Site, Georgsmarienhütte

49503

RECRUITING

Research Site, Grand Rapids

49684

WITHDRAWN

Research Site, Traverse City

51353

RECRUITING

Research Site, Changwon

53113

RECRUITING

Research Site, Bonn

54100

RECRUITING

Research Site, Adapazarı

56068

RECRUITING

Research Site, Koblenz

57105

RECRUITING

Research Site, Sioux Falls

59715

WITHDRAWN

Research Site, Bozeman

60521

NOT_YET_RECRUITING

Research Site, Hinsdale

64132

NOT_YET_RECRUITING

Research Site, Kansas City

68130

RECRUITING

Research Site, Omaha

68803

RECRUITING

Research Site, Grand Island

69126

RECRUITING

Research Site, Heidelberg

71640

RECRUITING

Research Site, Ludwigsburg

72205

RECRUITING

Research Site, Little Rock

72762

RECRUITING

Research Site, Springdale

76104

RECRUITING

Research Site, Fort Worth

77030

NOT_YET_RECRUITING

Research Site, Houston

WITHDRAWN

Research Site, Houston

77090

SUSPENDED

Research Site, Houston

77339

RECRUITING

Research Site, Kingwood

79106

RECRUITING

Research Site, Freiburg im Breisgau

79761

RECRUITING

Research Site, Odessa

80756

RECRUITING

Research Site, Kaohsiung City

81925

NOT_YET_RECRUITING

Research Site, München

82131

RECRUITING

Research Site, Gauting

85719

RECRUITING

Research Site, Tucson

87439

RECRUITING

Research Site, Kempten

88212

RECRUITING

Research Site, Ravensburg

89102

RECRUITING

Research Site, Las Vegas

89502

WITHDRAWN

Research Site, Reno

90110

NOT_YET_RECRUITING

Research Site, Hat Yai

90211

RECRUITING

Research Site, Beverly Hills

90419

RECRUITING

Research Site, Nuremberg

92663

NOT_YET_RECRUITING

Research Site, Newport Beach

92708

RECRUITING

Research Site, Fountain Valley

92801

RECRUITING

Research Site, Anaheim

97213

WITHDRAWN

Research Site, Portland

98405

RECRUITING

Research Site, Tacoma

98684

RECRUITING

Research Site, Vancouver

98801

RECRUITING

Research Site, Wenatchee

99508

RECRUITING

Research Site, Anchorage

100000

NOT_YET_RECRUITING

Research Site, Hanoi

NOT_YET_RECRUITING

Research Site, Hà Nội

100142

RECRUITING

Research Site, Beijing

101149

RECRUITING

Research Site, Beijing

110022

RECRUITING

Research Site, Shenyang

110075

RECRUITING

Research Site, Dwārka

110085

RECRUITING

Research Site, New Delhi

150049

RECRUITING

Research Site, Harbin

200030

RECRUITING

Research Site, Shanghai

200032

RECRUITING

Research Site, Shanghai

200433

RECRUITING

Research Site, Shanghai

210009

RECRUITING

Research Site, Nanjing

225001

RECRUITING

Research Site, Yangzhou

230031

WITHDRAWN

Research Site, Hefei

230601

RECRUITING

Research Site, Hefei

250117

RECRUITING

Research Site, Jinan

272011

RECRUITING

Research Site, Jining

276001

RECRUITING

Research Site, Linyi

280000

NOT_YET_RECRUITING

Research Site, Vĩnh Yên

300060

RECRUITING

Research Site, Tianjin

302004

RECRUITING

Research Site, Jaipur

WITHDRAWN

Research Site, Marg Jaipur

310006

RECRUITING

Research Site, Hangzhou

310016

RECRUITING

Research Site, Hangzhou

310022

RECRUITING

Research Site, Hangzhou

317000

RECRUITING

Research Site, Linhai

325000

RECRUITING

Research Site, Wenzhou

350014

RECRUITING

Research Site, Fuzhou

400030

RECRUITING

Research Site, Chongqing

410013

RECRUITING

Research Site, Changsha

422011

RECRUITING

Research Site, Nashik

430000

RECRUITING

Research Site, Wuhan

430010

RECRUITING

Research Site, Wuhan

430022

RECRUITING

Research Site, Wuhan

430030

RECRUITING

Research Site, Wuhan

440001

RECRUITING

Research Site, Nagpur

450000

RECRUITING

Research Site, Zhengzhou

450008

RECRUITING

Research Site, Zhengzhou

460000

NOT_YET_RECRUITING

Research Site, Vinh

510080

RECRUITING

Research Site, Guangzhou

530000

RECRUITING

Research Site, Nanning

NOT_YET_RECRUITING

Research Site, Huế

530021

RECRUITING

Research Site, Nanning

550000

NOT_YET_RECRUITING

Research Site, Da Nang

600031

RECRUITING

Research Site, Chennai

610000

RECRUITING

Research Site, Chengdu

610041

RECRUITING

Research Site, Chengdu

650118

RECRUITING

Research Site, Kunming

695011

RECRUITING

Research Site, Thiruvananthapuram

700000

NOT_YET_RECRUITING

Research Site, Ho Chi Minh City

700099

RECRUITING

Research Site, Kolkata

710061

RECRUITING

Research Site, Xi'an

730000

RECRUITING

Research Site, Lanzhou

02114

RECRUITING

Research Site, Boston

02215

RECRUITING

Research Site, Boston

08043

SUSPENDED

Research Site, Voorhees Township

QL 4101

RECRUITING

Research Site, South Brisbane

14784-400

RECRUITING

Research Site, Barretos

80730-150

RECRUITING

Research Site, Curitiba

88034-000

RECRUITING

Research Site, Florianópolis

35162-189

RECRUITING

Research Site, Ipatinga

59075-740

RECRUITING

Research Site, Natal

91350-200

RECRUITING

Research Site, Porto Alegre

22211-230

RECRUITING

Research Site, Rio de Janeiro

97015-450

RECRUITING

Research Site, Santa Maria

01221-020

RECRUITING

Research Site, São Paulo

12030-200

RECRUITING

Research Site, Taubaté

VSZ 4E6

RECRUITING

Research Site, Vancouver

R3E 0V9

WITHDRAWN

Research Site, Winnipeg

A1B 3V6

NOT_YET_RECRUITING

Research Site, St. John's

N6A 4L6

RECRUITING

Research Site, London

L3Y 2P9

WITHDRAWN

Research Site, Newmarket

L1G 2B9

RECRUITING

Research Site, Oshawa

M4N 3M5

WITHDRAWN

Research Site, Toronto

G6V 0B8

RECRUITING

Research Site, Lévis

H3T 1E2

RECRUITING

Research Site, Montreal

H3T 1M5

RECRUITING

Research Site, Montreal

H4J 1C5

RECRUITING

Research Site, Montreal

G5L 5T1

RECRUITING

Research Site, Rimouski

G8Z 3R9

RECRUITING

Research Site, Trois-Rivières

S7N 4H4

RECRUITING

Research Site, Saskatoon

G7H 5H6

RECRUITING

Research Site, Chicoutimi

030000

RECRUITING

Research Site, Taiyuan

07548

WITHDRAWN

Research Site, Gera

00128

RECRUITING

Research Site, Roma

113-8431

NOT_YET_RECRUITING

Research Site, Bunkyō City

160-0023

NOT_YET_RECRUITING

Research Site, Bunkyō City

812-8582

RECRUITING

Research Site, Fukuoka

814-0180

RECRUITING

Research Site, Fukuoka

350-1298

RECRUITING

Research Site, Hidaka-shi

573-1191

NOT_YET_RECRUITING

Research Site, Hirakata-shi

036-8563

RECRUITING

Research Site, Hirosaki-shi

730-8518

RECRUITING

Research Site, Hiroshima

920-8641

NOT_YET_RECRUITING

Research Site, Kanazawa

227-8577

RECRUITING

Research Site, Kashiwa

216-8511

RECRUITING

Research Site, Kawasaki-shi

860-8556

RECRUITING

Research Site, Kumamoto

460-0001

RECRUITING

Research Site, Nagoya

951-8566

NOT_YET_RECRUITING

Research Site, Niigata

700-8558

RECRUITING

Research Site, Okayama

545-8586

RECRUITING

Research Site, Osaka

589-8511

RECRUITING

Research Site, Osakasayama-shi

252-0375

RECRUITING

Research Site, Sagamihara-shi

003-0804

RECRUITING

Research Site, Sapporo

933-8555

RECRUITING

Research Site, Takaoka-shi

569-8686

RECRUITING

Research Site, Takatsuki-shi

770-8503

RECRUITING

Research Site, Tokushima

104-0045

RECRUITING

Research Site, Tokyo

320-0834

RECRUITING

Research Site, Utsunomiya

221-0855

RECRUITING

Research Site, Yokohama

10-357

RECRUITING

Research Site, Olsztyn

60-569

RECRUITING

Research Site, Poznan

37-700

RECRUITING

Research Site, Przemyśl

01-138

RECRUITING

Research Site, Warsaw

02-781

RECRUITING

Research Site, Warsaw

00909

RECRUITING

Research Site, San Juan

03080

RECRUITING

Research Site, Seoul

03722

RECRUITING

Research Site, Seoul

03010

RECRUITING

Research Site, Alicante

08003

RECRUITING

Research Site, Barcelona

08036

RECRUITING

Research Site, Barcelona

0116

NOT_YET_RECRUITING

Research Site, Taipei

TAIWAN

RECRUITING

Research Site, Taipei

06560

RECRUITING

Research Site, Ankara

07070

RECRUITING

Research Site, Antalya

GL53 7AN

RECRUITING

Research Site, Cheltenham

IV2 3UJ

RECRUITING

Research Site, Inverness

SE1 9RT

WITHDRAWN

Research Site, London

SW10 9NH

RECRUITING

Research Site, London

SW17 0QT

RECRUITING

Research Site, London

PR2 9HT

RECRUITING

Research Site, Preston

TR1 3LJ

RECRUITING

Research Site, Truro

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY

NCT06357533 - Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations | Biotech Hunter | Biotech Hunter