Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

220

Participants

Timeline

Start Date

May 20, 2024

Primary Completion Date

March 31, 2028

Study Completion Date

March 31, 2028

Conditions
Prostatic Neoplasms, Castration-Resistant
Interventions
DRUG

Opevesostat

Oral Tablet

DRUG

Olaparib

Oral Tablet

DRUG

Docetaxel

IV Infusion

DRUG

Cabazitaxel

IV Infusion

DRUG

Fludrocortisone acetate

Oral Tablet

DRUG

Dexamethasone

Oral Tablet

DRUG

Prednisone

Oral Tablet

Trial Locations (77)

112

RECRUITING

Taipei Veterans General Hospital ( Site 1701), Taipei

333

RECRUITING

Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1702), Taoyuan District

1023

RECRUITING

Auckland City Hospital ( Site 1333), Auckland

2109

RECRUITING

Macquarie University-MQ Health Clinical Trials Unit ( Site 0108), Macquarie University

2730

RECRUITING

Herlev and Gentofte Hospital ( Site 0501), Copenhagen

3000

RECRUITING

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0110), Melbourne

4120

RECRUITING

Gallipoli Medical Research Ltd-GMRF CTU ( Site 0107), Greenslopes

9000

RECRUITING

Aalborg Universitetshospital, Syd ( Site 0503), Aalborg

10117

RECRUITING

Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0800), Berlin

20089

RECRUITING

Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1101), Rozzano

20133

RECRUITING

Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1103), Milan

20246

RECRUITING

Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0804), Hamburg

21201

RECRUITING

University of Maryland-Greenebaum Comprehensive Cancer Center ( Site 0049), Baltimore

28007

RECRUITING

Hospital General Universitario Gregorio Marañón ( Site 1601), Madrid

28034

RECRUITING

Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1600), Madrid

28040

RECRUITING

Hospital Clinico San Carlos-Oncology Department ( Site 1604), Madrid

33076

RECRUITING

Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 0703), Bordeaux

33136

RECRUITING

University of Miami Hospital and Clinics, Sylvester Cancer Center-Cancer Research Services ( Site 0051), Miami

34668

RECRUITING

Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1804), Istanbul

34722

RECRUITING

TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1803), Istanbul

37134

RECRUITING

Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Roma-Oncology Unit ( Site 1100), Verona

44106

RECRUITING

University Hospitals Cleveland Medical Center ( Site 0043), Cleveland

53226

RECRUITING

MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0020), Milwaukee

65130

RECRUITING

Vaasan Keskussairaala ( Site 0603), Vaasa

67200

RECRUITING

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0700), Strasbourg

69120

RECRUITING

Universitaetsklinikum Heidelberg ( Site 0805), Heidelberg

72076

RECRUITING

Universitaetsklinikum Tuebingen-Urologie ( Site 0801), Tübingen

75015

RECRUITING

Hôpital Européen Georges Pompidou-Service d'Oncologie Médicale ( Site 0702), Paris

81675

RECRUITING

klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0802), Munich

83301

RECRUITING

Chang Gung Memorial Hospital at Kaohsiung-Oncology and Hematology ( Site 1704), Kaohsiung Niao Sung Dist

90404

RECRUITING

UCLA Hematology/Oncology - Santa Monica ( Site 0044), Los Angeles

92037

RECRUITING

UCSD Moores Cancer Center ( Site 0039), La Jolla

94805

RECRUITING

Gustave Roussy ( Site 0701), Villejuif

110131

RECRUITING

FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0406), Bogotá

111321

RECRUITING

Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia ( Site 0402), Bogotá

200001

RECRUITING

Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0400), Valledupar

230002

RECRUITING

IMAT S.A.S ( Site 0404), Montería

404332

RECRUITING

China Medical University Hospital ( Site 1703), Taichung

760032

RECRUITING

Fundación Valle del Lili-Oncology CIC ( Site 0403), Santiago de Cali

3109601

RECRUITING

Rambam Health Care Campus-Oncology Division ( Site 1002), Haifa

3465584

RECRUITING

Clinica Universidad Catolica del Maule-Oncology ( Site 0304), Talca

4810218

RECRUITING

CIDO SpA-Oncology ( Site 0302), Temuco

4941492

RECRUITING

Rabin Medical Center ( Site 1001), Petah Tikva

5265601

RECRUITING

Sheba Medical Center ( Site 1000), Ramat Gan

7500921

RECRUITING

FALP ( Site 0301), Santiago

8330024

RECRUITING

Pontificia Universidad Catolica de Chile ( Site 0303), Santiago

8420383

RECRUITING

Bradfordhill ( Site 0300), Santiago

08903-2681

RECRUITING

Rutgers Cancer Institute of New Jersey ( Site 0033), New Brunswick

H2X 3E4

RECRUITING

Centre Hospitalier de l'Université de Montréal ( Site 0200), Montreal

H3T 1E2

RECRUITING

Jewish General Hospital ( Site 0206), Montreal

G1J 1Z4

RECRUITING

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0207), Québec

00029

RECRUITING

Helsinki University Hospital - Comprehensive Cancer Center (HYKS - Syöpäkeskus) ( Site 0604), Helsinki

00180

RECRUITING

Docrates Syöpäsairaala ( Site 0602), Helsinki

D04 T6F4

RECRUITING

St. Vincent's University Hospital ( Site 0901), Dublin

T12 DC4A

RECRUITING

Cork University Hospital ( Site 0902), Cork

D24 NR0A

RECRUITING

Tallaght University Hospital ( Site 0900), Dublin

00168

RECRUITING

Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1102), Rome

285-8741

RECRUITING

Toho University Sakura Medical Center ( Site 1201), Sakura

232-0024

RECRUITING

Yokohama City University Medical Center ( Site 1203), Yokohama

105-8471

COMPLETED

The Jikei University Hospital ( Site 1202), Mitato

812-8582

RECRUITING

Kyushu University Hospital ( Site 1204), Fukuoka

85-796

RECRUITING

Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1402), Bydgoszcz

02-781

RECRUITING

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Oddzial Badan Wczesnych Faz ( Site 1400), Warsaw

80-952

RECRUITING

Uniwersyteckie Centrum Kliniczne ( Site 1405), Gdansk

05505

RECRUITING

Asan Medical Center-Oncology ( Site 1500), Songpagu

03722

RECRUITING

Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1502), Seoul

06351

RECRUITING

Samsung Medical Center-Division of Hematology/Oncology ( Site 1501), Seoul

08908

RECRUITING

Institut Català d'Oncologia - L'Hospitalet-Medical Oncology ( Site 1603), L'Hospitalet de Llobregat

08035

RECRUITING

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1602), Barcelona

01250

RECRUITING

Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1802), Adana

06230

RECRUITING

Hacettepe Universite Hastaneleri-oncology hospital ( Site 1800), Ankara

06800

RECRUITING

Ankara Bilkent Şehir Hastanesi ( Site 1801), Ankara

CB2 2QQ

RECRUITING

Addenbrooke's Hospital ( Site 1902), Cambridge

G12 0YN

RECRUITING

The Beatson West of Scotland Cancer Centre ( Site 1904), Glasgow

PR2 9HT

RECRUITING

Royal Preston Hospital-Lancashire Clinical Research Facility ( Site 1900), Preston

NW1 2PG

RECRUITING

University College London Hospital ( Site 1905), London

B15 2TH

RECRUITING

Queen Elizabeth Hospital Birmingham ( Site 1903), Birmingham

All Listed Sponsors
collaborator

Orion Corporation, Orion Pharma

INDUSTRY

lead

Merck Sharp & Dohme LLC

INDUSTRY