Personalized rTMS Protocol Based on Functional Reserve to Enhance Ambulatory Function in PD Patients

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

February 20, 2024

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2025

Conditions
Parkinson's Disease and Parkinsonism
Interventions
DEVICE

High-Frequency, ipsilateral M1

"rTMS intervention: 20 sessions of 10-Hz rTMS at 90% resting motor threshold (RMT), 50 pulses per session with a 25-second interval between sessions, totaling 1,000 pulses.~rTMS target: ipsilateral primary motor cortex of lower extremity.~Total rTMS sessions: once a day, 5 days per 2 weeks, for 4 weeks, totaling 10 sessions.~Additional treatment: Treadmill gait training after the intervention, as well as the routine pharmacotherapy based on the guidelines for management of patients with Parkinson's disease."

DEVICE

High-Frequency, bilateral M1

"rTMS intervention: 20 sessions of 10-Hz rTMS at 90% resting motor threshold (RMT), 50 pulses per session with a 25-second interval between sessions, totaling 1,000 pulses.~rTMS target: bilateral primary motor cortex of lower extremity.~Total rTMS sessions: once a day, 5 days per 2 weeks, for 4 weeks, totaling 10 sessions.~Additional treatment: Treadmill gait training after the intervention, as well as the routine pharmacotherapy based on the guidelines for management of patients with Parkinson's disease."

DEVICE

High-Frequency, Lt. DLPFC

"rTMS intervention: 20 sessions of 10-Hz rTMS at 90% resting motor threshold (RMT), 50 pulses per session with a 25-second interval between sessions, totaling 1,000 pulses.~rTMS target: Lt. DLPFC~Total rTMS sessions: once a day, 5 days per 2 weeks, for 4 weeks, totaling 10 sessions.~Additional treatment: Treadmill gait training after the intervention, as well as the routine pharmacotherapy based on the guidelines for management of patients with Parkinson's disease."

DEVICE

High-Frequency, bilateral M1

"rTMS intervention: 20 sessions of 10-Hz rTMS at 90% resting motor threshold (RMT), 50 pulses per session with a 25-second interval between sessions, totaling 1,000 pulses.~rTMS target: bilateral primary motor cortex of lower extremity.~Total rTMS sessions: once a day, 5 days per 2 weeks, for 4 weeks, totaling 10 sessions.~Additional treatment: Treadmill gait training after the intervention, as well as the routine pharmacotherapy based on the guidelines for management of patients with Parkinson's disease."

Trial Locations (1)

06351

RECRUITING

Samsung Medical Center, Seoul

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Research Foundation of Korea

OTHER

collaborator

Ministry of Food and Drug Safety, Korea

OTHER_GOV

collaborator

Seoul National University Hospital

OTHER

collaborator

Bucheon St. Mary's Hospital

OTHER

collaborator

Saint Vincent's Hospital, Korea

OTHER

collaborator

Severance Hospital

OTHER

collaborator

Kumoh National Institute of Technology

UNKNOWN

collaborator

NEUROPHET

INDUSTRY

lead

Samsung Medical Center

OTHER