Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

582

Participants

Timeline

Start Date

April 29, 2024

Primary Completion Date

March 21, 2028

Study Completion Date

May 25, 2032

Conditions
Non-small Cell Lung Cancer
Interventions
DRUG

Osimertinib

"Arm 1: Osimertinib 80 mg QD as oral tablet with Datopotamab Deruxtecan 6mg/kg as i.v. infusion.~Arm 2: Osimertinib 80 mg QD as oral tablet ."

DRUG

Datopotamab Deruxtecan

Osimertinib 80 mg QD as oral tablet with Datopotamab Deruxtecan 6mg/kg as i.v. infusion.

Trial Locations (163)

106

RECRUITING

Research Site, Taipei

333

RECRUITING

Research Site, Taoyuan District

704

RECRUITING

Research Site, Tainan City

1060

RECRUITING

Research Site, Seyhan

2050

NOT_YET_RECRUITING

Research Site, Camperdown

2145

RECRUITING

Research Site, Westmead

2217

RECRUITING

Research Site, Kogarah

3168

RECRUITING

Research Site, Clayton

4101

RECRUITING

Research Site, South Brisbane

8036

RECRUITING

Research Site, Barcelona

10002

RECRUITING

Research Site, Taipei

10043

RECRUITING

Research Site, Orbassano

10065

NOT_YET_RECRUITING

Research Site, New York

10300

RECRUITING

Research Site, Dusit

10400

RECRUITING

Research Site, Bangkok

10700

RECRUITING

Research Site, Bangkok

11029

RECRUITING

Research Site, New Delhi

13125

RECRUITING

Research Site, Berlin

13915

RECRUITING

Research Site, Marseille

15006

RECRUITING

Research Site, A Coruña

16544

RECRUITING

Research Site, Erie

18007

RECRUITING

Research Site, Granada

20037

NOT_YET_RECRUITING

Research Site, Washington D.C.

20141

RECRUITING

Research Site, Milan

20817

RECRUITING

Research Site, Bethesda

20900

RECRUITING

Research Site, Monza

21565

RECRUITING

Research Site, Namdong-gu

22031

RECRUITING

Research Site, Fairfax

22060

NOT_YET_RECRUITING

Research Site, Fort Belvoir

23114

NOT_YET_RECRUITING

Research Site, Midlothian

24105

NOT_YET_RECRUITING

Research Site, Kiel

28040

RECRUITING

Research Site, Madrid

28222

RECRUITING

Research Site, Majadahonda

31000

RECRUITING

Research Site, Hangzhou

32256

RECRUITING

Research Site, Jacksonville

32763

NOT_YET_RECRUITING

Research Site, Orange City

34295

RECRUITING

Research Site, Küçükçekmece

34376

RECRUITING

Research Site, Immenhausen

34474

NOT_YET_RECRUITING

Research Site, Ocala

35100

NOT_YET_RECRUITING

Research Site, Izmir

35128

RECRUITING

Research Site, Padua

37075

NOT_YET_RECRUITING

Research Site, Göttingen

40705

RECRUITING

Research Site, Taichung

41000

RECRUITING

Research Site, Udon Thani

43100

RECRUITING

Research Site, Parma

46009

RECRUITING

Research Site, Valencia

46845

RECRUITING

Research Site, Fort Wayne

48201

NOT_YET_RECRUITING

Research Site, Detroit

49055

RECRUITING

Research Site, Angers

51109

RECRUITING

Research Site, Cologne

53226

NOT_YET_RECRUITING

Research Site, Milwaukee

54100

RECRUITING

Research Site, Adapazarı

55102

RECRUITING

Research Site, Saint Paul

55131

RECRUITING

Research Site, Mainz

60064

NOT_YET_RECRUITING

Research Site, North Chicago

60488

RECRUITING

Research Site, Frankfurt

63044

WITHDRAWN

Research Site, Bridgeton

63110

RECRUITING

Research Site, St Louis

70000

RECRUITING

Research Site, Ho Chi Minh City

75005

RECRUITING

Research Site, Paris

75390

WITHDRAWN

Research Site, Dallas

76712

RECRUITING

Research Site, Woodway

77030

RECRUITING

Research Site, Houston

77090

SUSPENDED

Research Site, Houston

77598

RECRUITING

Research Site, Webster

81925

NOT_YET_RECRUITING

Research Site, München

89169

RECRUITING

Research Site, Las Vegas

90017

RECRUITING

Research Site, Los Angeles

90033

RECRUITING

Research Site, Los Angeles

90095

NOT_YET_RECRUITING

Research Site, Los Angeles

90110

RECRUITING

Research Site, Hat Yai

90720

RECRUITING

Research Site, Los Alamitos

92123

NOT_YET_RECRUITING

Research Site, San Diego

92708

NOT_YET_RECRUITING

Research Site, Fountain Valley

92868

NOT_YET_RECRUITING

Research Site, Orange

94598

RECRUITING

Research Site, Walnut Creek

96819

WITHDRAWN

Research Site, Honolulu

98104

WITHDRAWN

Research Site, Seattle

99089

RECRUITING

Research Site, Erfurt

100000

RECRUITING

Research Site, Hanoi

RECRUITING

Research Site, Hà Nội

100029

RECRUITING

Research Site, Beijing

100034

RECRUITING

Research Site, Beijing

100049

NOT_YET_RECRUITING

Research Site, New Delhi

100142

RECRUITING

Research Site, Beijing

110004

RECRUITING

Research Site, Shenyang

110085

NOT_YET_RECRUITING

Research Site, Delhi

130000

RECRUITING

Research Site, Changchun

150049

RECRUITING

Research Site, Harbin

200030

RECRUITING

Research Site, Shanghai

200433

NOT_YET_RECRUITING

Research Site, Shanghai

221000

RECRUITING

Research Site, Xuzhou

221005

SUSPENDED

Research Site, Varanasi

225001

RECRUITING

Research Site, Yangzhou

230031

RECRUITING

Research Site, Hefei

230601

RECRUITING

Research Site, Hefei

250021

RECRUITING

Research Site, Jinan

250117

RECRUITING

Research Site, Jinan

310006

RECRUITING

Research Site, Hangzhou

310022

RECRUITING

Research Site, Hangzhou

315010

RECRUITING

Research Site, Ningbo

317000

RECRUITING

Research Site, Linhai

325000

RECRUITING

Research Site, Wenzhou

391760

RECRUITING

Research Site, Vadodara

400030

RECRUITING

Research Site, Chongqing

402260

RECRUITING

Research Site, Chongqing

410013

RECRUITING

Research Site, Changsha

422011

RECRUITING

Research Site, Nashik

430022

RECRUITING

Research Site, Wuhan

430030

RECRUITING

Research Site, Wuhan

440001

NOT_YET_RECRUITING

Research Site, Nagpur

450000

RECRUITING

Research Site, Zhengzhou

450008

RECRUITING

Research Site, Zhengzhou

460000

RECRUITING

Research Site, Vinh

500032

RECRUITING

Research Site, Hyderabad

510100

RECRUITING

Research Site, Guangzhou

560027

NOT_YET_RECRUITING

Research Site, Bangalore

570017

NOT_YET_RECRUITING

Research Site, Mysuru

610000

RECRUITING

Research Site, Chengdu

610042

RECRUITING

Research Site, Chengdu

610072

RECRUITING

Research Site, Chengdu

650118

RECRUITING

Research Site, Kunming

700000

RECRUITING

Research Site, Ho Chi Minh City

700054

SUSPENDED

Research Site, Kolkata

710061

RECRUITING

Research Site, Xi'an

999077

RECRUITING

Research Site, Hong Kong

06510

RECRUITING

Research Site, New Haven

14784-400

RECRUITING

Research Site, Barretos

59075-740

RECRUITING

Research Site, Natal

91350-200

RECRUITING

Research Site, Porto Alegre

41253-190

RECRUITING

Research Site, Salvador

01246-000

RECRUITING

Research Site, São Paulo

T6G 1Z2

RECRUITING

Research Site, Edmonton

H4A 3J1

RECRUITING

Research Site, Montreal

67091, Cedex

RECRUITING

Research Site, Strasbourg

Unknown

NOT_YET_RECRUITING

Research Site, Hong Kong

NOT_YET_RECRUITING

Research Site, Lai Chi Kok

NOT_YET_RECRUITING

Research Site, Goztepe Istanbul

RECRUITING

Research Site, Ho Chi Minh City

HKG

RECRUITING

Research Site, Jordan

104-0045

RECRUITING

Research Site, Chūōku

812-8582

RECRUITING

Research Site, Fukuoka

277-8577

RECRUITING

Research Site, Kashiwa

135-8550

RECRUITING

Research Site, Kōtoku

951-8566

RECRUITING

Research Site, Niigata

541-8567

RECRUITING

Research Site, Osaka

589-8511

RECRUITING

Research Site, Osakasayama-shi

003-0804

RECRUITING

Research Site, Sapporo

981-0914

RECRUITING

Research Site, Sendai

641-8510

RECRUITING

Research Site, Wakayama

241-8515

RECRUITING

Research Site, Yokohama

43-360

RECRUITING

Research Site, Bystra

10-357

RECRUITING

Research Site, Olsztyn

60-569

RECRUITING

Research Site, Poznan

02-781

RECRUITING

Research Site, Warsaw

00935

RECRUITING

Research Site, Rio Piedras

00918

NOT_YET_RECRUITING

Research Site, San Juan

410-769

RECRUITING

Research Site, Goyang-si

03080

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

120-752

RECRUITING

Research Site, Seoul

TAIWAN

RECRUITING

Research Site, Taipei

06530

RECRUITING

Research Site, Ankara

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY