130
Participants
Start Date
November 20, 2024
Primary Completion Date
November 1, 2026
Study Completion Date
November 1, 2030
FDOPA injection before PET imaging
Fluorodopa labelled with fluorine 18 (physical half-life of 109.6 min) is used at a dosage of 1 to 2 MBq/kg in neuroimaging, depending on the sensitivity of the PET camera used. For these reasons, a dose of 2 MBq/kg will be administered slowly intravenously (approximately 1 minute for a maximum bolus of 10 mL). PET acquisitions will be performed at 90 minutes post-injection and will last 30 minutes. Participants will be asked to have fasted for at least 4 hours at the time of injection, with no restriction on fluid intake.
Time perception tasks
The main tasks involves the comparison of duration to assess aging effects on the precision of temporal representations
fMRI imaging
Imaging of brain structure during the completion of the time perception task
EEG imaging
Recording of neural dynamics during the completion of the time perception task
3 year follow-up
Behavioral and EEG follow-up (for older adults only)
RECRUITING
Cyceron Boulevard Henri Becquerel, Caen
Institut National de la Santé Et de la Recherche Médicale, France
OTHER_GOV