Uncovering the Cognitive and Neural Mechanisms Underlying Cognitive Time

RecruitingOBSERVATIONAL
Enrollment

130

Participants

Timeline

Start Date

November 20, 2024

Primary Completion Date

November 1, 2026

Study Completion Date

November 1, 2030

Conditions
Healthy Aging
Interventions
RADIATION

FDOPA injection before PET imaging

Fluorodopa labelled with fluorine 18 (physical half-life of 109.6 min) is used at a dosage of 1 to 2 MBq/kg in neuroimaging, depending on the sensitivity of the PET camera used. For these reasons, a dose of 2 MBq/kg will be administered slowly intravenously (approximately 1 minute for a maximum bolus of 10 mL). PET acquisitions will be performed at 90 minutes post-injection and will last 30 minutes. Participants will be asked to have fasted for at least 4 hours at the time of injection, with no restriction on fluid intake.

BEHAVIORAL

Time perception tasks

The main tasks involves the comparison of duration to assess aging effects on the precision of temporal representations

DEVICE

fMRI imaging

Imaging of brain structure during the completion of the time perception task

DEVICE

EEG imaging

Recording of neural dynamics during the completion of the time perception task

BEHAVIORAL

3 year follow-up

Behavioral and EEG follow-up (for older adults only)

Trial Locations (1)

14074

RECRUITING

Cyceron Boulevard Henri Becquerel, Caen

All Listed Sponsors
lead

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV