Study of Plozasiran (ARO-APOC3) in Adults With Severe Hypertriglyceridemia

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

446

Participants

Timeline

Start Date

July 22, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

September 30, 2026

Conditions
Severe Hypertriglyceridemia
Interventions
DRUG

Plozasiran Injection

ARO-APOC3 Injection

DRUG

Placebo

sterile normal saline (0.9% NaCl)

Trial Locations (196)

1033

Research Center 1, Budapest

1051

Research Center 4, Budapest

1132

Research Center 2, Budapest

1152

Research Center 6, Budapest

1336

Research Center 13, Sofia

1404

Research Center 6, Sofia

1431

Research Center 5, Sofia

1527

Research Center 15, Sofia

Research Center 7, Sofia

1642

Research Center 10, San Isidro

1680

Research Center 14, Sofia

2139

Research Center 4, Concord

2148

Research Center 1, Blacktown

2291

Research Center 5, Merewether

2700

Research Center 12, Blagoevgrad

2800

Research Center 3, Mechelen

3084

Research Center 3, Heidelberg

3138

Research Center 2, Box Hill

3168

Research Center 7, Clayton

3500

Research Center 6, Hasselt

4001

Research Center 4, Plovdiv

4002

Research Center 2, Plovdiv

4004

Research Center 9, Plovdiv

5000

Research Center 4, Córdoba

5008

Research Center 9, Córdoba

5101

Research Center 2, Namur

5800

Research Center 1, Pleven

Research Center 3, Pleven

6009

Research Center 6, Crawley

6534

Research Center 4, Gozée

6600

Research Center 10, Kardzhali

6725

Research Center 3, Szeged

7000

Research Center 11, Rousse

8000

Research Center 8, Burgas

8200

Research Center 5, Veszprém

8800

Research Center 5, Roeselare

9230

Research Center 1, Wetteren

10000

Research Center 1, Zagreb

Research Center 3, Zagreb

Research Center 4, Zagreb

10010

Research Center 2, Žilina

10016

Research Center 30, New York

10034

Research Center 1, Beijing

10455

Research Center 28, The Bronx

11000

Research Center 7, Praha 1-Nove Mesto

11106

Research Center 29, Long Island City

13850

Research Center 32, Vestal

14010

Research Center 16, Baotou

14642

Research Center 31, Rochester

20089

Research Center 3, Rozzano

20162

Research Center 4, Milan

21229

Research Center 19, Baltimore

25123

Research Center 5, Brescia

27157

Research Center 34, Winston-Salem

28557

Research Center 33, Morehead City

31210

Research Center 15, Macon

31401

Research Center 16, Savannah

32055

Research Center 8, Lake City

32503

Research Center 12, Pensacola

32757

Research Center 10, Mt. Dora

32825

Research Center 11, Orlando

33014

Research Center 9, Miami Lakes

33016

Research Center 7, Hialeah

33321

Research Center 13, Tamarac

33614

Research Center 14, Tampa

37849

Research Center 39, Powell

38654

Research Center 22, Olive Branch

40113

Research Center 9, Ústí nad Labem

40138

Research Center 6, Bologna

43210

Research Center 36, Columbus

44000

Research Center 2, Yuncheng

45219

Research Center 35, Cincinnati

46010

Research Center 1, Valencia

48532

Research Center 20, Flint

49217

Research Center 2, Krapinske Toplice

50005

Research Center 6, Hradec Králové

50009

Research Center 4, Zaragoza

55455

Research Center 21, Minneapolis

60068

Research Center 17, Park Ridge

63136

Research Center 24, St Louis

65109

Research Center 23, Jefferson City

68114

Research Center 26, Omaha

68144

Research Center 25, Omaha

68601

Research Center 2, Uherské Hradiště

69501

Research Center 3, Hodonín

70200

Research Center 1, Ostrava

70535

Research Center 18, Eunice

73072

Research Center 37, Norman

73111

Research Center 38, Oklahoma City

75093

Research Center 50, Plano

77029

Research Center 47, Houston

77030

Research Center 45, Houston

Research Center 46, Houston

77061

Research Center 42, Houston

77074

Research Center 44, Houston

77079

Research Center 43, Houston

77095

Research Center 41, Houston

77459

Research Center 49, Missouri City

78041

Research Center 48, Laredo

78230

Research Center 51, San Antonio

79905

Research Center 40, El Paso

80909

Research Center 6, Colorado Springs

81109

Research Center 5, Bratislava

89119

Research Center 27, Las Vegas

90127

Research Center 2, Palermo

91402

Research Center 4, Panorama City

91763

Research Center 3, Montclair

92630

Research Center 2, Lake Forest

92844

Research Center 1, Garden Grove

96001

Research Center 5, Redding

97401

Research Center 4, Banská Bystrica

98109

Research Center 52, Seattle

100191

Research Center 23, Beijing

100342

Research Center 4, Ploieşti

100730

Research Center 22, Beijing

200050

Research Center 12, Shanghai

215002

Research Center 10, Suzhou

233004

Research Center 11, Bengbu

252000

Research Center 3, Liaocheng

300121

Research Center 20, Tianjin

300362

Research Center 5, Timișoara

311100

Research Center 5, Hangzhou

325000

Research Center 15, Wenzhou

330006

Research Center 14, Nanchang

330084

Research Center 8, Deva

400000

Research Center 2, Cluj-Napoca

410011

Research Center 4, Changsha

410015

Research Center 18, Changsha

430060

Research Center 21, Wuhan

471003

Research Center 6, Luoyang

500091

Research Center 3, Brasov

510053

Research Center 6, Alba Iulia

510080

Research Center 19, Guanzhou

510180

Research Center 7, Guangzhou

540136

Research Center 9, Târgu Mureş

545006

Research Center 8, Liuzhou

610072

Research Center 17, Chengdu

800291

Research Center 7, Galati

2000040

Research Center 9, Shanghai

B1704ETD

Research Center 8, Ramos Mejía

B1834GUK

Research Center 7, Temperley

X5000AAW

Research Center 5, Córdoba

X5006CBI

Research Center 3, Córdoba

C1417

Research Center 6, Buenos Aires

C1425AGC

Research Center 2, Buenos Aires

C1430

Research Center 1, Buenos Aires

29055-450

Research Center 10, Vitória

40050-410

Research Center 12, Salvador

40323-010

Research Center 13, Salvador

41810-010

Research Center 14, Salvador

30220-140

Research Center 5, Belo Horizonte

83430-000

Research Center 8, Campina Grande do Sul

80730-150

Research Center 2, Curitiba

66073-000

Research Center 4, Belém

90035-903

Research Center 6, Porto Alegre

90430-001

Research Center 9, Porto Alegre

13083-190

Research Center 1, Campinas

04266-010

Research Center 7, São Paulo

05403-000

Research Center 11, São Paulo

15501-405

Research Center 3, Votuporanga

V8T 5G4

Research Center 3, Victoria

L6S 0C6

Research Center 1, Brampton

N6A 5A5

Research Center 8, London

N7T 4X3

Research Center 2, Sarnia

N2TOC1

Research Center 5, Waterloo

H2W 1R7

Research Center 6, Montreal

G1V 4W2

Research Center 4, Québec

B3H 1V7

Research Center 7, Halifax

054099

Research Center 13, Xingtai

140 21

Research Center 8, Prague

140 59

Research Center 4, Prague

Research Center 5, Praha 4-Krc

00168

Research Center 1, Roma

58-130

Research Center 15, Żarów

85-231

Research Center 7, Bydgoszcz

82-300

Research Center 11, Elblag

40-752

Research Center 10, Katowice

30-727

Research Center 13, Krakow

31-202

Research Center 17, Krakow

31-501

Research Center 8, Krakow

91-363

Research Center 12, Lodz

00-215

Research Center 18, Warsaw

03-291

Research Center 9, Warsaw

53-030

Research Center 16, Wroclaw

53-673

Research Center 14, Wroclaw

010192

Research Center 1, Bucharest

040 01

Research Center 1, Košice

045 01

Research Center 3, Moldava nad Bodvou

08501

Research Center 6, Bardejov

08023

Research Center 2, Barcelona

08035

Research Center 3, Barcelona

PL11 2TB

Research Center 3, Torpoint

TQ2 7AA

Research Center 5, Torquay

PL5 3JB

Research Center 2, Plymouth

EC1M 6BQ

Research Center 1, London

N12 8BU

Research Center 4, London

Sponsors
All Listed Sponsors
lead

Arrowhead Pharmaceuticals

INDUSTRY