NCT06346392View on ClinicalTrials.gov

AZD0901 Compared With Investigator's Choice of Therapy in Participants With Second- or Later-line Advanced or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma Expressing Claudin18.2

PHASE3RecruitingINTERVENTIONAL
Enrollment

572

Participants

Timeline

Start Date

March 4, 2024

Primary Completion Date

October 19, 2026

Study Completion Date

April 19, 2027

Conditions
Gastric CancerGastroesophageal Junction Cancer
Interventions
DRUG

AZD0901

Participants in the AZD0901 arm 1 will receive dose level 1 AZD0901 IV

DRUG

AZD0901

Participants in the AZD0901 arm 2 will receive dose level 2 AZD0901 IV (Enrolment was closed)

DRUG

Ramucirumab+ paclitaxel

Ramucirumab 8 mg/kg IV on Days 1 and 15 and paclitaxel 80 mg/m2 IV on Days 1, 8, and 15, Q4W

DRUG

Paclitaxel

Paclitaxel 80 mg/m2 IV on Days 1, 8, and 15, Q4W (for participants with contraindication to ramucirumab only)

DRUG

Docetaxel

Docetaxel 75-100 mg/m2 IV on Day 1, Q3W (for participants with contraindication to ramucirumab only)

DRUG

Irinotecan

Irinotecan 150-180 mg/m2 IV on Days 1 and 15, Q4W

DRUG

TAS-102

TAS-102 35 mg/m2 up to a maximum of 80 mg orally twice a day on Days 1 to 5 and Days 8 to 12, Q4W (except China)

DRUG

Apatinib

Apatinib 500-850 mg at Investigator's discretion based on participant's condition and tolerability, orally once daily, Q4W (China only)

Trial Locations (186)

112

RECRUITING

Research Site, Taipei

333

RECRUITING

Research Site, Taoyuan District

1011

RECRUITING

Research Site, Lausanne

1205

RECRUITING

Research Site, Geneva

3010

RECRUITING

Research Site, Bern

8032

RECRUITING

Research Site, Zurich

8035

RECRUITING

Research Site, Barcelona

10002

RECRUITING

Research Site, Taipei

10016

RECRUITING

Research Site, New York

10032

RECRUITING

Research Site, New York

10065

RECRUITING

Research Site, New York

10249

RECRUITING

Research Site, Berlin

10300

RECRUITING

Research Site, Dusit

10700

RECRUITING

Research Site, Bangkok

11501

RECRUITING

Research Site, Mineola

13353

RECRUITING

Research Site, Berlin

13620

RECRUITING

Research Site, Gyeonggi-do

17403

RECRUITING

Research Site, York

19111

RECRUITING

Research Site, Philadelphia

20007

RECRUITING

Research Site, Washington D.C.

20133

RECRUITING

Research Site, Milan

20162

RECRUITING

Research Site, Milan

20246

RECRUITING

Research Site, Hamburg

21280

RECRUITING

Research Site, Diyarbakır

21287

WITHDRAWN

Research Site, Baltimore

22408

RECRUITING

Research Site, Fredericksburg

22908

RECRUITING

Research Site, Charlottesville

25030

RECRUITING

Research Site, Besançon

25240

RECRUITING

Research Site, Erzurum

28034

RECRUITING

Research Site, Madrid

28041

RECRUITING

Research Site, Madrid

29200

RECRUITING

Research Site, Brest

30060

RECRUITING

Research Site, Marietta

30322

WITHDRAWN

Research Site, Atlanta

32003

RECRUITING

Research Site, Fleming Island

32005

RECRUITING

Research Site, Ourense

32804

RECRUITING

Research Site, Orlando

33021

RECRUITING

Research Site, Hollywood

34098

RECRUITING

Research Site, Istanbul

35043

RECRUITING

Research Site, Marburg

35128

RECRUITING

Research Site, Padua

35233

WITHDRAWN

Research Site, Birmingham

36100

RECRUITING

Research Site, Vicenza

36604

RECRUITING

Research Site, Mobile

37075

RECRUITING

Research Site, Göttingen

39008

RECRUITING

Research Site, Santander

40002

RECRUITING

Research Site, Khon Kaen

40447

RECRUITING

Research Site, Taichung

40536

RECRUITING

Research Site, Lexington

41013

RECRUITING

Research Site, Seville

41124

NOT_YET_RECRUITING

Research Site, Modena

44000

RECRUITING

Research Site, Nantes

45136

WITHDRAWN

Research Site, Essen

45219

WITHDRAWN

Research Site, Cincinnati

47441

RECRUITING

Research Site, Moers

48106

RECRUITING

Research Site, Ann Arbor

48109

RECRUITING

Research Site, Ann Arbor

50134

RECRUITING

Research Site, Florence

55131

WITHDRAWN

Research Site, Mainz

56100

RECRUITING

Research Site, Pisa

59037

RECRUITING

Research Site, Lille

60488

RECRUITING

Research Site, Frankfurt

63110

WITHDRAWN

Research Site, St Louis

63128

WITHDRAWN

Research Site, St Louis

64111

RECRUITING

Research Site, Kansas City

69008

RECRUITING

Research Site, Lyon

69120

RECRUITING

Research Site, Heidelberg

74078

RECRUITING

Research Site, Heilbronn

75571

RECRUITING

Research Site, Paris

80131

RECRUITING

Research Site, Napoli

81377

RECRUITING

Research Site, München

83301

RECRUITING

Research Site, Kaohsiung City

83712

RECRUITING

Research Site, Boise

85719

RECRUITING

Research Site, Tucson

86021

RECRUITING

Research Site, Poitiers

90048

RECRUITING

Research Site, Los Angeles

90089

RECRUITING

Research Site, Los Angeles

90110

RECRUITING

Research Site, Hat Yai

91010

RECRUITING

Research Site, Duarte

92618

RECRUITING

Research Site, Irvine

92663

RECRUITING

Research Site, Newport Beach

92835

WITHDRAWN

Research Site, Fullerton

95403

WITHDRAWN

Research Site, Santa Rosa

96819

RECRUITING

Research Site, Honolulu

97239

WITHDRAWN

Research Site, Portland

98109

WITHDRAWN

Research Site, Seattle

98502

RECRUITING

Research Site, Olympia

100000

RECRUITING

Research Site, Hanoi

100210

RECRUITING

Research Site, Beijing

110042

RECRUITING

Research Site, Shenyang

110085

RECRUITING

Research Site, New Delhi

130021

RECRUITING

Research Site, Changchun

150001

RECRUITING

Research Site, Hong Kong

150049

RECRUITING

Research Site, Harbin

200025

RECRUITING

Research Site, Shanghai

200032

RECRUITING

Research Site, Shanghai

200040

RECRUITING

Research Site, Shanghai

210008

RECRUITING

Research Site, Nanjing

210009

WITHDRAWN

Research Site, Nanjing

215004

RECRUITING

Research Site, Suzhou

230022

RECRUITING

Research Site, Hefei

230031

RECRUITING

Research Site, Hefei

230601

RECRUITING

Research Site, Hefei

250117

RECRUITING

Research Site, Jinan

266003

RECRUITING

Research Site, Qingdao

272029

RECRUITING

Research Site, Jining

300060

RECRUITING

Research Site, Tianjin

310020

RECRUITING

Research Site, Hangzhou

310022

RECRUITING

Research Site, Hangzhou

323000

RECRUITING

Research Site, Lishui

350001

RECRUITING

Research Site, Fuzhou

350014

RECRUITING

Research Site, Fuzhou

380015

RECRUITING

Research Site, Ahmedabad

400012

RECRUITING

Research Site, Mumbai

410013

WITHDRAWN

Research Site, Changsha

430000

RECRUITING

Research Site, Wuhan

430030

RECRUITING

Research Site, Wuhan

450003

RECRUITING

Research Site, Zhengzhou

460000

RECRUITING

Research Site, Vinh

471003

WITHDRAWN

Research Site, Luoyang

500032

RECRUITING

Research Site, Hyderabad

510060

RECRUITING

Research Site, Guangzhou

510120

RECRUITING

Research Site, Guangzhou

510655

RECRUITING

Research Site, Guangzhou

510700

RECRUITING

Research Site, Guangzhou

560027

NOT_YET_RECRUITING

Research Site, Bengaluru

610000

RECRUITING

Research Site, Chengdu

610042

RECRUITING

Research Site, Chengdu

700000

RECRUITING

Research Site, Ho Chi Minh City

710061

RECRUITING

Research Site, Xi'an

730000

RECRUITING

Research Site, Lanzhou

750004

RECRUITING

Research Site, Yinchuan

830000

RECRUITING

Research Site, Ürümqi

02114

RECRUITING

Research Site, Boston

91350-200

NOT_YET_RECRUITING

Research Site, Porto Alegre

14051-140

RECRUITING

Research Site, Ribeirão Preto

05652-900

RECRUITING

Research Site, São Paulo

29043-272

RECRUITING

Research Site, Vitória

T2N 4N2

WITHDRAWN

Research Site, Calgary

L4M 6M2

RECRUITING

Research Site, Barrie

N6C 2R5

RECRUITING

Research Site, London

M2K 1E1

RECRUITING

Research Site, North York

K1H 8L6

RECRUITING

Research Site, Ottawa

M5G 2M9

RECRUITING

Research Site, Toronto

H3G 1A4

RECRUITING

Research Site, Montreal

H3T 1E2

WITHDRAWN

Research Site, Montreal

050011

RECRUITING

Research Site, Shijiazhuang

01067

WITHDRAWN

Research Site, Dresden

01370

WITHDRAWN

Research Site, Dresden

04103

RECRUITING

Research Site, Leipzig

Unknown

RECRUITING

Research Site, Hong Kong

RECRUITING

Research Site, Tainan City

812-8582

RECRUITING

Research Site, Fukuoka

227-8577

RECRUITING

Research Site, Kashiwa

135-8550

RECRUITING

Research Site, Kōtoku

464-8681

RECRUITING

Research Site, Nagoya

503-8502

RECRUITING

Research Site, Ogaki-shi

541-8567

RECRUITING

Research Site, Osaka

411-8777

RECRUITING

Research Site, Sunto-gun

104-0045

RECRUITING

Research Site, Tokyo

470-1192

RECRUITING

Research Site, Toyoake-shi

241-8515

RECRUITING

Research Site, Yokohama

43-300

RECRUITING

Research Site, Bielsko-Biala

80-219

RECRUITING

Research Site, Gdansk

40-514

RECRUITING

Research Site, Katowice

31-501

RECRUITING

Research Site, Krakow

20-080

RECRUITING

Research Site, Lublin

71-730

WITHDRAWN

Research Site, Szczecin

76-200

RECRUITING

Research Site, Słupsk

97-200

WITHDRAWN

Research Site, Tomaszów Mazowiecki

02-034

RECRUITING

Research Site, Warsaw

04-141

RECRUITING

Research Site, Warsaw

03080

RECRUITING

Research Site, Seoul

03722

RECRUITING

Research Site, Seoul

05505

ACTIVE_NOT_RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

06591

RECRUITING

Research Site, Seoul

08036

RECRUITING

Research Site, Barcelona

00807

RECRUITING

Research Site, Kaohsiung City

06230

RECRUITING

Research Site, Ankara

CB2 0QQ

RECRUITING

Research Site, Cambridge

EC1A 7BE

RECRUITING

Research Site, London

SW3 6JJ

RECRUITING

Research Site, London

M20 4BX

RECRUITING

Research Site, Manchester

OX3 7LE

RECRUITING

Research Site, Oxford

TA1 5DA

RECRUITING

Research Site, Taunton

Sponsors

Lead Sponsor

AstraZeneca
All Listed Sponsors
lead

AstraZeneca

INDUSTRY